Impact of antiresorptive drugs on dental implant success rate: A systematic review
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Purpose: This systematic review aimed to evaluate the impact of antiresorptive drugs on dental implant success rate, and to suggest guidelines for dental implant placement in patients under antiresorptive therapies. Materials and Methods: An electrical search was conducted in databases such as PubMed and Cochrane, followed by Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. the review included studies from 2014 march, focusing on various study designs like randomized control studies, cohort studies, and case series. Results: In a total of 196 articles, based on inclusion criteria, 9 articles were selected. the dental implant success rates across the studies ranged from 36.2% to 100%. a notable association was identified between the dosage and administration route of antiresorptive drugs and dental implant success rates. additionally, presence of dental implant could be potential risk for Medication-Related Osteonecrosis of the Jaw (MRONJ) onset in patients under antiresorptive therapy. Conclusion: Low dose and oral administration of antiresorptive drugs seem to present a lower risk of dental im- plant failure. a multidisciplinary approach is important when considering dental implants for patients on antire- sorptive therapy. Further research is required to refine clinical guidelines for enhanced patient safety and better outcomes in dental implantology. (J Korean Dent Assoc 2025; 63(5): 153-161)
Abstract
Purpose: This systematic review aimed to evaluate the impact of antiresorptive drugs on dental implant success rate, and to suggest guidelines for dental implant placement in patients under antiresorptive therapies. Materials and Methods: An electrical search was conducted in databases such as PubMed and Cochrane, followed by Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. the review included studies from 2014 march, focusing on various study designs like randomized control studies, cohort studies, and case series. Results: In a total of 196 articles, based on inclusion criteria, 9 articles were selected. the dental implant success rates across the studies ranged from 36.2% to 100%. a notable association was identified between the dosage and administration route of antiresorptive drugs and dental implant success rates. additionally, presence of dental implant could be potential risk for Medication-Related Osteonecrosis of the Jaw (MRONJ) onset in patients under antiresorptive therapy. Conclusion: Low dose and oral administration of antiresorptive drugs seem to present a lower risk of dental im- plant failure. a multidisciplinary approach is important when considering dental implants for patients on antire- sorptive therapy. Further research is required to refine clinical guidelines for enhanced patient safety and better outcomes in dental implantology. (J Korean Dent Assoc 2025; 63(5): 153-161)