Effects of coffee intake on airway hypersensitivity and immunomodulation: an in vivo murine study
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BACKGROUND/OBJECTIVES: Coffee is a complex chemical mixture, with caffeine being the most well-known bioactive substance. The immunomodulator y and anti-inflammator y properties of coffee and caffeine impact health in various aspects, including the respirator y system. The objective is to investigate the effects of coffee and caffeine on air way hyperresponsiveness and allergic reactions, as well as to analyze and compare associated cytokine profiles. MATERIALS/METHODS: BALB/c mice were intraperitoneally sensitized with ovalbumin (OVA) and given OVA inhalation to induce air way hypersensitivity. Two weeks after sensitization, they were intragastrically gavaged with coffee or caffeine, both containing 0.3125 mg caffeine, daily for 4 weeks. Control mice were fed with double-distilled water. Serum OVA- specific antibody levels were measured beforehand and 5 weeks after the first gavage. Air way hyperresponsiveness was detected by whole body plethysmography after gavage. Cytokine levels of bronchoalveolar lavage and cultured splenocytes were analyzed. RESULTS: Coffee effectively suppressed T helper 2-mediated specific antibody response. Air way responsiveness was reduced in mice treated with either coffee or caffeine. Compared to the control, coffee significantly reduced OVA-specific immunoglobulin (Ig) G, IgG1 and IgE antibody responses (P < 0.05). Caffeine also attenuated specific IgG and IgG1 levels, though IgE level was unaffected. Coffee significantly reduced interleukin (IL)-4 and increased IL-10 concentration in spleen cells and bronchoalveolar lavage fluid (P < 0.05). CONCLUSIONS: Coffee effectively attenuated air way hyperresponsiveness and systemic allergic responses induced by OVA food allergen in mice. As a complex composition of bioactive substances, coffee displayed enhanced immunomodulator y and anti-inflammator y effects than caffeine.
Abstract
BACKGROUND/OBJECTIVES: Coffee is a complex chemical mixture, with caffeine being the most well-known bioactive substance. The immunomodulator y and anti-inflammator y properties of coffee and caffeine impact health in various aspects, including the respirator y system. The objective is to investigate the effects of coffee and caffeine on air way hyperresponsiveness and allergic reactions, as well as to analyze and compare associated cytokine profiles. MATERIALS/METHODS: BALB/c mice were intraperitoneally sensitized with ovalbumin (OVA) and given OVA inhalation to induce air way hypersensitivity. Two weeks after sensitization, they were intragastrically gavaged with coffee or caffeine, both containing 0.3125 mg caffeine, daily for 4 weeks. Control mice were fed with double-distilled water. Serum OVA- specific antibody levels were measured beforehand and 5 weeks after the first gavage. Air way hyperresponsiveness was detected by whole body plethysmography after gavage. Cytokine levels of bronchoalveolar lavage and cultured splenocytes were analyzed. RESULTS: Coffee effectively suppressed T helper 2-mediated specific antibody response. Air way responsiveness was reduced in mice treated with either coffee or caffeine. Compared to the control, coffee significantly reduced OVA-specific immunoglobulin (Ig) G, IgG1 and IgE antibody responses (P < 0.05). Caffeine also attenuated specific IgG and IgG1 levels, though IgE level was unaffected. Coffee significantly reduced interleukin (IL)-4 and increased IL-10 concentration in spleen cells and bronchoalveolar lavage fluid (P < 0.05). CONCLUSIONS: Coffee effectively attenuated air way hyperresponsiveness and systemic allergic responses induced by OVA food allergen in mice. As a complex composition of bioactive substances, coffee displayed enhanced immunomodulator y and anti-inflammator y effects than caffeine.
참고문헌 (31)
- Jeszka-Skowron M, "Analytical methods applied for the characterization and the determination of bioactive compounds in coffee", Eur Food Res Technol, 240, pp.19~31 (2015)
- Poole R, "Coffee consumption and health : umbrella review of meta-analyses of multiple health outcomes", BMJ, 359, pp.j5024~ (2017)[DOI]
- Bravi F, "Coffee and the risk of hepatocellular carcinoma and chronic liver disease : a systematic review and meta-analysis of prospective studies", Eur J Cancer Prev, 26, pp.368~377 (2017)[DOI]
- Caini S, "Coffee, tea and caffeine intake and the risk of non-melanoma skin cancer : a review of the literature and meta-analysis", Eur J Nutr, 56, pp.1~12 (2017)[DOI]
- Johnson S, "Coffee consumption and reduced risk of hepatocellular carcinoma : findings from the Singapore Chinese Health Study", Cancer Causes Control, 22, pp.503~510 (2011)[DOI]
- Liu H, "Coffee consumption and prostate cancer risk : a meta-analysis of cohort studies", Nutr Cancer, 67, pp.392~400 (2015)[DOI]
- Wang A, "Coffee and cancer risk : a meta-analysis of prospective observational studies", Sci Rep, 6, pp.33711~ (2016)[DOI]
- Zhou Q, "Coffee consumption and risk of endometrial cancer : a doseresponse meta-analysis of prospective cohort studies", Sci Rep, 5, pp.13410~ (2015)[DOI]
- Wijarnpreecha K, "Coffee consumption and risk of nonalcoholic fatty liver disease : a systematic review and meta-analysis", Eur J Gastroenterol Hepatol, 29, pp.e8~e12 (2017)[DOI]
- Zhang YP, "Systematic review with meta-analysis : coffee consumption and the risk of gallstone disease", Aliment Pharmacol Ther, 42, pp.637~648 (2015)[DOI]
- Liu F, "Coffee consumption decreases risks for hepatic fibrosis and cirrhosis : a meta-analysis", PLoS One, 10, pp.e0142457~ (2015)[DOI]
- Baspinar B, "How coffee affects metabolic syndrome and its components", Food Funct, 8, pp.2089~2101 (2017)[DOI]
- Grosso G, "Coffee consumption and risk of all-cause, cardiovascular, and cancer mortality in smokers and nonsmokers : a dose-response meta-analysis", Eur J Epidemiol, 31, pp.1191~1205 (2016)[DOI]
- Rodríguez-Artalejo F, "Coffee consumption and cardiovascular disease : a condensed review of epidemiological evidence and mechanisms", J Agric Food Chem, 66, pp.5257~5263 (2018)[DOI]
- Wang L, "Coffee and caffeine consumption and depression : a meta-analysis of observational studies", Aust N Z J Psychiatry, 50, pp.228~242 (2016)[DOI]
- Grosso G, "Coffee, tea, caffeine and risk of depression : a systematic review and dose-response meta-analysis of observational studies", Mol Nutr Food Res, 60, pp.223~234 (2016)[DOI]
- Park KY, "Effects of coffee consumption on serum uric acid : systematic review and meta-analysis", Semin Arthritis Rheum, 45, pp.580~586 (2016)[DOI]
- Peerapen P, "Caffeine in kidney stone disease : risk or benefit?", Adv Nutr, 9, pp.419~424 (2018)[DOI]
- Alfaro TM, "Chronic coffee consumption and respiratory disease : a systematic review", Clin Respir J, 12, pp.1283~1294 (2018)[DOI]
- Oñatibia-Astibia A, "The potential of methylxanthine-based therapies in pediatric respiratory tract diseases", Respir Med, 112, pp.1~9 (2016)
- Sharif K, "Coffee and autoimmunity: more than a mere hot beverage!", Autoimmun Rev, 16, pp.712~721 (2017)[DOI]
- Peng HJ, "Chemical denaturation of ovalbumin abrogates the induction of oral tolerance of specific IgG antibody and DTH responses in mice", Scand J Immunol, 42, pp.297~304 (1995)[DOI]
- Khan DA, "Asthma", Ann Allergy Asthma Immunol, 123, pp.416~417 (2019)[DOI]
- Kelada SN, "Plethysmography phenotype QTL in mice before and after allergen sensitization and challenge", G3(Bethesda), 6, pp.2857~2865 (2016)[DOI]
- Lambrecht BN, "The immunology of asthma", Nat Immunol, 16, pp.45~56 (2015)[DOI]
- Goto M, "Continuous orally administered coffee enhanced the antigen-specific Th1 response and reduced allergic development in a TCR-transgenic mice model", Biosci Biotechnol Biochem, 73, pp.2439~2444 (2009)[DOI]
- Lajunen K, "Abnormal lung function at preschool age asthma in adolescence?", Ann Allergy Asthma Immunol, 120, pp.520~526 (2018)[DOI]
- Brigham EP, "Diagnosis of asthma: diagnostic testing", Forum Allergy Rhinol, 5(Suppl 1), pp.S27~S30 (2015)[DOI]
- Forte GC, "Diet effects in the asthma treatment : a systematic review", Crit Rev Food Sci Nutr, 58, pp.1878~1887 (2018)[DOI]
- Horrigan LA, "Immunomodulatory effects of caffeine : friend or foe?", Pharmacol Ther, 111, pp.877~892 (2006)[DOI]
- Pohanka M, "Caffeine downregulates antibody production in a mouse model", J Appl Biomed, 13, pp.1~6 (2014)