Lentinus edodes Suppresses Allergen-Induced Airway Hyperresponsiveness and Inflammation by Downregulating Nuclear Factor-kappa B Activity in a Murine Model of Allergic Asthma
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Medicinal mushrooms have been shown to have profound health promoting benefits. Among them,Lentinus edodes is well-known to have anti-tumor, anti-inflammatory, and immunomodulatory effects. The aimof the present study is to evaluate whether Lentinus edodes ethanol extract (LE) inhibit airway inflammatoryresponse in a murine asthma model induced by exposure to ovalbumin (OVA). The pretreatment of LE substantiallyattenuated airway hyperresponsiveness and eosinophilic inflammation in OVA-challenged mice. Inaddition, the increased levels of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and adhesion molecules inbronchoalveolar lavage fluids at 48 h after OVA inhalation was significantly reduced by the administration of LE. Furthermore, LE suppressed OVA-induced activation of nuclear factor-kappa B and p38 mitogen-activatedprotein kinase in lung tissues. Taken together, it is proposed that LE may serve as an effective therapeutic agentfor allergic airway disease.
Abstract
Medicinal mushrooms have been shown to have profound health promoting benefits. Among them,Lentinus edodes is well-known to have anti-tumor, anti-inflammatory, and immunomodulatory effects. The aimof the present study is to evaluate whether Lentinus edodes ethanol extract (LE) inhibit airway inflammatoryresponse in a murine asthma model induced by exposure to ovalbumin (OVA). The pretreatment of LE substantiallyattenuated airway hyperresponsiveness and eosinophilic inflammation in OVA-challenged mice. Inaddition, the increased levels of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and adhesion molecules inbronchoalveolar lavage fluids at 48 h after OVA inhalation was significantly reduced by the administration of LE. Furthermore, LE suppressed OVA-induced activation of nuclear factor-kappa B and p38 mitogen-activatedprotein kinase in lung tissues. Taken together, it is proposed that LE may serve as an effective therapeutic agentfor allergic airway disease.
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