Association between BRAFV600E Mutations and Clinicopathological Features of Papillary Thyroid Microcarcinoma (PTMC)
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Purpose: In this study, the relationship between the BRAFV600E mutation and the clinicopathological features of papillary thyroid microcarcinoma (PTMC) was examined in a single center. Methods: From January 2011 to December 2012, a total of 911 patients with PTMC who underwent thyroidectomy at Severance Hospital, Korea were enrolled in this study. The status of BRAFV600E mutation was assessed in thyroid fine-needle aspiration specimens by real-time polymerase chain reaction amplification prior to thyroidectomy. The associations between BRAFV600E mutation status and clinicopathological features of PTMC were examined. Results: The overall prevalence of the BRAFV600E mutations was 78.8% (717/911). Chi-square analysis revealed that BRAFV600E mutations were significantly associated with the male sex, lateral neck node metastasis, and several risk factors. And the age, tumor size, extent of surgery, multiplicity, bilaterality, central node metastasis, and distant metastasis were not associated with BRAFV600E mutation. Multivariate analysis showed that capsular invasion and lateral neck node metastasis were significantly associated with BRAFV600E mutations. In particular, lateral neck node metastasis showed negative correlation with BRAFV600E mutations. And the recurrence rate and disease-free survival were not associated with BRAFV600E mutation status. Conclusion: BRAFV600E mutations in PTMC was associated with presence of capsular invasion and absence of lateral neck node metastasis. However, BRAFV600E mutations could not serve as a prognostic factor that affected the recurrence of PTMC in our study.
Abstract
Purpose: In this study, the relationship between the BRAFV600E mutation and the clinicopathological features of papillary thyroid microcarcinoma (PTMC) was examined in a single center. Methods: From January 2011 to December 2012, a total of 911 patients with PTMC who underwent thyroidectomy at Severance Hospital, Korea were enrolled in this study. The status of BRAFV600E mutation was assessed in thyroid fine-needle aspiration specimens by real-time polymerase chain reaction amplification prior to thyroidectomy. The associations between BRAFV600E mutation status and clinicopathological features of PTMC were examined. Results: The overall prevalence of the BRAFV600E mutations was 78.8% (717/911). Chi-square analysis revealed that BRAFV600E mutations were significantly associated with the male sex, lateral neck node metastasis, and several risk factors. And the age, tumor size, extent of surgery, multiplicity, bilaterality, central node metastasis, and distant metastasis were not associated with BRAFV600E mutation. Multivariate analysis showed that capsular invasion and lateral neck node metastasis were significantly associated with BRAFV600E mutations. In particular, lateral neck node metastasis showed negative correlation with BRAFV600E mutations. And the recurrence rate and disease-free survival were not associated with BRAFV600E mutation status. Conclusion: BRAFV600E mutations in PTMC was associated with presence of capsular invasion and absence of lateral neck node metastasis. However, BRAFV600E mutations could not serve as a prognostic factor that affected the recurrence of PTMC in our study.
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