갑상선 유두암에서 BRAFV600E 돌연변이와 연관된 임상병리학적 인자 및 초음파 소견과의 연관성
Association of BRAFV600E Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma
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Purpose: This study evaluated the association of the BRAFV600E mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma. Methods: Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011. Results: Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAFV600E mutation. Neither age nor sex were associated with the BRAFV600E mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAFV600E mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation. Conclusion: As debate remains about the association between the BRAFV600E mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed.
Abstract
Purpose: This study evaluated the association of the BRAFV600E mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma. Methods: Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011. Results: Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAFV600E mutation. Neither age nor sex were associated with the BRAFV600E mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAFV600E mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation. Conclusion: As debate remains about the association between the BRAFV600E mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed.
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