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창부도담탕의 다낭성 난소 증후군 치료 효과에 관한 동물 실험연구 고찰

A Review of Animal Experiments on Changbudodam-tang Treating Polycystic Ovary Syndrome

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Objectives: The aim of this review is to investigate the research trends of animal experiments on Changbudodam-tang treating polycystic ovary syndrome (PCOS). Methods: The data base RISS, OASIS, KMBASE, Pubmed, EMBASE, and CNKI were searched using the terms PCOS, Polycystic ovary, Changbudodam-tang and Cang Fu Dao Tan Tang. The characteristics of the animal experiment and the results of the selected studies were analyzed. Results: Of 461 studies, 13 original articles were analyzed. All studies used rat models, and the letrozole with high fat diet model was the most common model for PCOS. The compositions of Changbudodam-tang administered in the experiments were quite diverse. Changbudodam-tang had a significant effect on treating PCOS model compared to the control groups. Conclusions: The Animal research articles suggested that treating PCOS with Changbudodam-tang has complex therapeutic effects by improving and modulating ovarian structures, sex hormones, glucose and lipid metabolism, and various genes and proteins in multiple cell pathways.

Abstract

Objectives: The aim of this review is to investigate the research trends of animal experiments on Changbudodam-tang treating polycystic ovary syndrome (PCOS). Methods: The data base RISS, OASIS, KMBASE, Pubmed, EMBASE, and CNKI were searched using the terms PCOS, Polycystic ovary, Changbudodam-tang and Cang Fu Dao Tan Tang. The characteristics of the animal experiment and the results of the selected studies were analyzed. Results: Of 461 studies, 13 original articles were analyzed. All studies used rat models, and the letrozole with high fat diet model was the most common model for PCOS. The compositions of Changbudodam-tang administered in the experiments were quite diverse. Changbudodam-tang had a significant effect on treating PCOS model compared to the control groups. Conclusions: The Animal research articles suggested that treating PCOS with Changbudodam-tang has complex therapeutic effects by improving and modulating ovarian structures, sex hormones, glucose and lipid metabolism, and various genes and proteins in multiple cell pathways.

참고문헌 (46)

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