다낭성 난소 증후군의 당-지질대사 이상에 대한 한약 임상 연구 고찰
A Study on the Clinical Study of Herbal Medicine for Glucose-Lipid Metabolism Abnormalities in Polycystic Ovary Syndrome
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Objectives: The purpose of this study is to investigate the effect of herbal medicine treatment for glucose and lipid metabolic abnormalities caused by polycystic ovary syndrome (PCOS). Methods: We searched for randomized controlled clinical trials (RCTs) in 6 electronic databases and search key words were ‘PCOS’ and ‘chinese medicine’ or ‘herbal medicine’ and ‘Metabolic syndrome’ or ‘glucose’ or ‘lipid’. The results of the studies were analyzed and the risk of bias was assessed by using Cochrane risk of bias (RoB) tool. Results: We finally selected 7 studies. In 3 of selected studies, herbal medicine was more effective than western medicine in all outcomes and in other 3 selected studies, herbal medicine was partially more effective than western medicine. Conclusions: The study provides a basis for applying herbal medicine treatment to patients with metabolic syndrome caused by PCOS and helps developing a treatment protocol of caring patients with PCOS. But the limitation of this study is that the number of studies included is small and lack of uniformity of outcome indicators made it difficult to observe overall interrelationship between indicators.
Abstract
Objectives: The purpose of this study is to investigate the effect of herbal medicine treatment for glucose and lipid metabolic abnormalities caused by polycystic ovary syndrome (PCOS). Methods: We searched for randomized controlled clinical trials (RCTs) in 6 electronic databases and search key words were ‘PCOS’ and ‘chinese medicine’ or ‘herbal medicine’ and ‘Metabolic syndrome’ or ‘glucose’ or ‘lipid’. The results of the studies were analyzed and the risk of bias was assessed by using Cochrane risk of bias (RoB) tool. Results: We finally selected 7 studies. In 3 of selected studies, herbal medicine was more effective than western medicine in all outcomes and in other 3 selected studies, herbal medicine was partially more effective than western medicine. Conclusions: The study provides a basis for applying herbal medicine treatment to patients with metabolic syndrome caused by PCOS and helps developing a treatment protocol of caring patients with PCOS. But the limitation of this study is that the number of studies included is small and lack of uniformity of outcome indicators made it difficult to observe overall interrelationship between indicators.
참고문헌 (23)
- The society of korean medicine obstetrics and gynecology, "Korean Medicine Obstetrics & Gynecology. II", pp.182~192 (2016), Euiseongdang Publishing Inc
- Dunaif A, "Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome", Diabetes, 41(10), pp.1257~1266 (1992)
- Ehrman DA, "Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome", Diabetes Care, 22(1), pp.141~146 (1999)
- Haffner SM, "Low insulin sensitivity(S(i)= 0)in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study : is it associated with components of the metabolic syndrome and nontraditional risk factors?", Diabetes Care, 26(10), pp.2796~2803 (2003)
- Reaven GM, "Insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension. Parallels between human disease and rodent models", Diabetes Care, 14(3), pp.195~202 (1991)
- Vrbikova J, "Metabolic syndrome in young Czech women with polycystic ovary syndrome", Hum Reprod, 20(12), pp.3328~3332 (2005)
- Glueck CJ, "Incidence and treatment of metabolic syndrome in newly referred women with confirmed polycystic ovarian syndrome", Metabolism, 52(7), pp.908~915 (2003)
- 이혜진, "젊은 한국인 다낭성난소증후군 환자에서 대사증후군의 유병률", Diabetes and Metabolism Journal, 30(4), pp.285~291 (2006), 대한당뇨병학회
- 황주연, "다낭성난소증후군과 인슐린 저항성", Obstetrics & Gynecology Science, 49(6), pp.1179~1187 (2006), 대한산부인과학회
- 배주은, "다낭성 난소 증후군을 이환하는 난임 환자에서 통합 의학 치료의 효과 : 체계적 문헌 고찰 및 메타분석", 대한한방부인과학회지, 30(4), pp.59~76 (2017), 대한한방부인과학회[DOI]
- 이지현, "다낭성난소증후군으로 인한 무월경, 희발월경 환자 20명의 증례 보고", 대한한방부인과학회지, 29(3), pp.47~56 (2016), 대한한방부인과학회[DOI]
- 여은주, "半夏가 다낭성 난소 증후군이 유발된 흰쥐의 난소 조직에 미치는 영향", 대한한방부인과학회지, 25(2), pp.66~77 (2012), 대한한방부인과학회[DOI]
- 박철이, "香附子가 다낭성난소증후군에 수반되는 대사증후군 관련병태에 미치는 영향", 대한한방부인과학회지, 24(4), pp.20~30 (2011), 대한한방부인과학회
- 류기준, "當歸가 다낭성난소증후군이 유발된 흰쥐 난소조직의 유전자 발현에 미치는 영향", 대한한방부인과학회지, 24(3), pp.28~47 (2011), 대한한방부인과학회
- 이연경, "歸脾湯이 Estradiol Valerate로 유도된 흰쥐의 다낭성 난소에 미치는 영향", 대한한방부인과학회지, 21(3), pp.60~74 (2008), 대한한방부인과학회
- 조혜숙, "다낭성 난소 증후군에 대한 침치료 연구 동향", Korean Journal of Acupuncture, 28(3), pp.165~175 (2011), 경락경혈학회
- Chen Y, "Clinical observation on 30 cases of obesity-type polycystic ovary syndrome treated with Tonifying kidney, activating blood, resolving phlegm chinese medicine(补肾活血化痰中药治疗肥胖型多囊卵巢综合征30例临床观察)", Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine, 15(10), pp.36~38 (2015)
- Luo J, "Clinical observation on invigorating kidney to remove phlegm and stasis in treating PCOS-IR", Hubei Journal of Traditional Chinese Medicine, 32(6), pp.14~15 (2010)
- Zhang Y, "Effect of Cangfudaotan decoction on hormone and lipid metabolism in obesity-type polycystic ovary syndrome(中药苍附导痰汤对肥胖型多囊卵巢综合征激素及脂代谢的影响研究)", Heilongjiang Medicine Journal, 30(6), pp.1293~1295 (2017)
- Wan J, "Effect of Cangfudaotan decoction on hormone level and lipid metabolism in patients with obesity-type polycystic ovary syndrome(苍附导痰汤加减对肥胖型多囊卵巢综合征患者激素水平及脂代谢的影响)", Shanxi Journal of Traditional Chinese Medicine, 38(2), pp.219~221 (2017)
- Hong YW, "Clinical observation on 23 cases of obesity-type polycystic ovary syndrome treated with Tonifying spleen, dispelling phlegm, unblocking circulation decoction(健脾祛痰通络方治疗肥胖型多囊卵巢综合征23例)", Jiangxi Journal of Traditional Chinese Medicine, 47(10), pp.48~50 (2016)
- Chen WJ, "Effect of quyu huatan decoction on lipid metabolism and hormone levels of patients with polycystic ovary syndrome", China Journal of Chinese Meteria Medica, 41(3), pp.532~535 (2016)
- Liu ST, "Tonifying kidney, resolving phlegm and removing blood stasis in treating cases clinical observations of obesity-type polycystic ovary syndrome", Chinese Journal of Ethnomedicine and Ethnopharmacy, 24(22), pp.60~61 (2015)
