요로감염에서 Staphylococcus saprophyticus 분리 빈도와 임상적 특징
Frequency and Clinical Characteristics of Urinary Tract Infections Caused by Staphylococcus saprophyticus
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배경: Staphylococcus saprophyticus는 요로감염의 중요한 원인균으로서, 특히 젊은 여성에서는 두 번째로 흔한 것으로 알 려져 있으나 국내에서의 빈도에 대하여 알려진 바가 거의 없다. 이에 요로감염에서 S. saprophyticus 분리 빈도와 임상적 특징에 대하여 조사하였다. 방법: 1996년 7월부터 2008년 6월까지 12년간 원주기독병원에 내원한 환자의 요배양에서 집락수가 104/mL 이상으로 분 리된 모든 균종을 대상으로 하여 S. saprophyticus의 비율을 알아보았고, 대상 환자들에 대한 후향적 의무기록 조사를 통 해 임상적 특징을 분석하였다. 결과: 12년 동안 요배양에서 분리된 균수는 24,277건이었고 이 중 S. saprophyticus는 21건으로 분리율은 0.09%였다. S. saprophyticus의 외래환자에서의 분리율은 21건 중 12건(57%)으로 전체 분리 균종의 외래환자에서의 분리율인 21% (5,098/24,277)에 비해 높았다. 여성에서의 S. saprophyticus 분리율은 15∼34세의 젊은 연령에서 가장 높은 빈도를 보였다. 전체 분리 균종의 월별 분포는 일정하였으나 S. saprophyticus는 21건 중 16건(76%)이 여름과 가을(6∼11월)에 분리되었다. 결론: S. saprophyticus에 의한 요배양 양성률은 전체의 0.09%, 여성의 0.17%로 외국에 비해 매우 낮았다. 향후 국내의 다른 지역에서의 S. saprophyticus에 의한 요로감염의 빈도에 대한 조사가 필요할 것으로 생각되었다.
Abstract
Background: Staphylococcus saprophyticus is the second most common cause of urinary tract infections (UTIs) in young women. As little is known about the incidence of UTIs caused by this organism in Korea, we examined its frequency and clinical characteristics. Methods: We analyzed the frequency of S. saprophyticus among organisms isolated from urine specimens in Wonju Christian Hospital from July 1996 to June 2008 and reviewed clinical characteristics retrospectively. Results: Of 24,277 strains isolated from urine specimens during the past 12 years, 21 (0.09%) were S. saprophyticus. Outpatients were more common in the S. saprophyticus group than in all patients group (12 of 21, 57% vs 5,098 of 24,277, 21%). The incidence of S. saprophyticus in women was the highest in the group of 15 to 34 years of age. Monthly distributions of isolates were almost constant in all patient groups, while 16 of 21 (76%) cases of the S. saprophyticus group occurred in summer and fall (June to November). Conclusion: The fequencies of S. saprophyticus among organisms isolated from urine specimens in all patient groups and women were 0.09% and 0.17%, respectively, and are much lower than those in other countries. However, we need further studies to examine the prevalence of S. saprophyticus UTIs in other regions of this country.
참고문헌 (29)
- Foxman B, "Epidemiology of urinary tract infections: incidence, morbidity, and economic costs", Am J Med, 49, pp.56~70 (2002)
- Naber KG, "Surveillance study in Europe and Brazil on clinical aspects and Antimicrobial Resistance Epidemiology in Females with Cystitis (ARESC): implications for empiric therapy", Eur Urol, 54, pp.1164~1175 (2008)
- Torres Pereira A, "Coagulase-negative strains of staphylococcus possessing antigen 51 as agent of urinary infection", J Clin Pathol, 15, pp.252~253 (1962)
- Wallmark G, "Staphylococcus saprophyticus: a frequent cause of acute urinary tract infection among female outpatients", J Infect Dis, 138, pp.791~797 (1978)
- Schneider PF, "Staphylococcus saprophyticus urinary tract infections: epidemiological data from Western Australia", Eur J Epidemiol, 12, pp.51~54 (1996)
- Nys S, "Urinary tract infections in general practice patients: diagnostic tests versus bacteriological culture", J Antimicrob Chemother, 57, pp.955~958 (2006)
- Moon HW, "Urinary tract infection due to coagulasenegative staphylococci: species identification, antimicrobial resistance and clinical characteristics", Korean J Clin Microbiol, 6, pp.23~28 (2003)
- Colodner R, "Epidemiology and clinical characteristics of patients with Staphylococcus saprophyticus bacteriuria in Israel", Infection, 34, pp.278~281 (2006)
- Gillespie WA, "Urinary tract infection in young women, with special reference to Staphylococcus saprophyticus", J Clin Pathol, 31, pp.348~350 (1978)
- Jordan PA, "Urinary tract infection caused by Staphylococcus saprophyticus", J Infect Dis, 142, pp.510~515 (1980)
- Fihn SD, "Use of spermicide-coated condoms and other risk factors for urinary tract infection caused by Staphylococcus saprophyticus", Arch Intern Med, 158, pp.281~287 (1998)
- Hovelius B, "Urinary tract infections caused by Staphylococcus saprophyticus: recurrences and complications", J Urol, 122, pp.645~647 (1979)
- Sellin M, "Micrococcal urinary-tract infections in young women", Lancet, 2, pp.570~572 (1975)
- Hedman P, "Urinary tract infections caused by Staphylococcus saprophyticus. A matched case control study", J Infect, 23, pp.145~153 (1991)
- Rupp ME, "Colonization of the female genital tract with Staphylococcus saprophyticus", J Clin Microbiol, 30, pp.2975~2979 (1992)
- Maskell R, "Importance of coagulase-negative staphylococci as pathogens in the urinary tract", Lancet, 1, pp.1155~1158 (1974)
- Hovelius B, "Staphylococcus saprophyticus as a common cause of urinary tract infections", Rev Infect Dis, 6, pp.328~337 (1984)
- Ishihara S, "Pathologic significance of Staphylococcus saprophyticus in complicated urinary tract infections", Urology, 57, pp.17~20 (2001)
- Latham RH, "Use of a novobiocin-containing medium for isolation of Staphylococcus saprophyticus from urine", J Clin Microbiol, 17, pp.1161~1162 (1983)
- Marrie TJ, "Staphylococcus saprophyticus as a cause of urinary tract infections", J Clin Microbiol, 16, pp.427~431 (1982)
- "1979", 87
- Mårdh PA, "Attachment of bacteria to exfoliated cells from the urogenital tract", Invest Urol, 16, pp.322~326 (1979)
- Hell W, "Cloning of aas, a gene encoding a Staphylococcus saprophyticus surface protein with adhesive and autolytic properties", Mol Microbiol, 29, pp.871~881 (1998)
- Sakinc T, "The surfaceassociated protein of Staphylococcus saprophyticus is a lipase", Infect Immun, 73, pp.6419~6428 (2005)
- Sakinc T, "SdrI, a serine-aspartate repeat protein identified in Staphylococcus saprophyticus strain 7108, is a collagen-binding protein", Infect Immun, 74, pp.4615~4623 (2006)
- Nicolle LE, "Susceptibility of clinical isolates of Staphylococcus saprophyticus to fifteen commonly used antimicrobial agents", Antimicrob Agents Chemother, 22, pp.895~896 (1982)
- Kahlmeter G, "An international survey of the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections: the ECO.SENS project", J Antimicrob Chemother, 51, pp.69~76 (2003)
- Performance Standards for Antimicrobial Susceptibility Testing; Eighteenth Informational Supplement, "Clinical and Laboratory Standards Institute", CLSI, ~, pp.CLSI document M100-S18 (2008)
- Higashide M, "of a cefoxitin disk diffusion test for the detection of mecA-positive methicillin-resistant Staphylococcus saprophyticus", Int J Antimicrob Agents, 27, pp.500~504 (2006)