본문 바로가기
KERD
논문KCI 등재

소목 추출물의 항산화 효능과 항균 효과

Antioxidant and antibacterial effects of Caesalpinia sappan L. extract

윤세은|박승아|김규천|박상례|최별보라
대한구강해부학회 (The Korean Academy Of Oral Anatomy)|2024.12|대한구강해부학회지 (The Korean Journal of Oral Anatomy)|제45권 제1호|pp. 47-55|DOI 10.35607/kjoa.45.1.202412.007

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

antioxidant항균antibacterial항산화구강균oral bacteria소목 추출물caesalpinia sappan L. extract

초록

구강 내 전염성 질환은 주로 박테리아로 인해 발생하며 이를 치료하기 위해 원인균에 대한 성장 억제 기능을 하는 항균제제가 요구되고 있다. 소목(Caesalpinia sappan L.) 추출물은 과거로부터 여러 질병을 치료하기 위해 민간 의학에서 사용되어 온 전통 한약재로 알려져 있다. 본 연구는 소목 추출물이 항산화 효능을 나타내고 구강균에 대해 균 성장 억제 및 사멸 효과가 나타나는지 평가하였다. 실험 결과 소목 추출물의 항산화 효능은 높게 나타났으며, 또한 농도 의존적으로 구강균 성장 억제 및 사멸 효과가 나타난 것으로 확인되었다. 이에 소목 추출물은 항산화 효능과 균에 대한 항균 효과가 있다는 사실이 입증되었으며 차후 구강 내 항균 물질로 적용 가능성이 있음을 시사한다.

Abstract

Infectious diseases in the oral cavity are primarily caused by bacteria, necessitating efficacious antibacterial agents that inhibit causative bacteria proliferation. Caesalpinia sappan L. extract is a traditional herbal medicine used in folk medicine to treat various diseases. This study assessed the antioxidant efficacy and antibacterial activity of Caesalpinia sappan L. extract against oral bacteria. Caesalpinia sappan L. extract exhibited a concentration-dependent bactericidal effect against oral bacteria. This finding suggests that Caesalpinia sappan L. extract possesses antioxidant and antibacterial properties, indicating its potential as an oral antibacterial agent.

참고문헌 (30)

  1. Lemos JA, "The Biology of Streptococcus mutans", Microbiol Spectr, 7(1) (2019)[DOI]
  2. Oh HN, "Effect of bamboo salt on the caries activity of Streptococcus mutans", J Korean Acad Oral Health, 40(4), pp.238~243 (2016)[DOI]
  3. Blancas B, "Study of the ultrastructure of Enterococcus faecalis and Streptococcus mutans incubated with salivary antimicrobial peptides", Clin Exp Dent Res, 7(3), pp.365~375 (2021)[DOI]
  4. Mattos BS, "Candida albicans in patients with oronasal communication and obturator prostheses", Braz Dent J, 20(4), pp.336~340 (2009)[DOI]
  5. Nirmal NP, "Antioxidant, antibacterial, and anti-inflammatory activities of standardized brazilin-rich Caesalpinia sappan extract", Pharm Biol, 53(9), pp.1339~1343 (2015)[DOI]
  6. Świętek M, "Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles", Beilstein J Nanotechnol, 20(10), pp.1073~1088 (2019)[DOI]
  7. Lee JY, "Antimicrobial Activity and Bactericidal Activity of Caesalpinia sappan L. Extract", J Environ Health Sci, 37(2), pp.133~140 (2011)[DOI]
  8. Vij T, "A Comprehensive Review on Bioactive Compounds Found in Caesalpinia sappan", Molecules, 28(17), pp.6247~ (2023)[DOI]
  9. Suyatmi S, "Brazilin Isolated from Caesalpina Sappan Wood Induces Intrinsic Apoptosis on A549 Cancer Cell Line by Increasing p53, caspase-9, and caspase-3", Asian Pac J Cancer Prev, 23(4), pp.1337~1343 (2022)[DOI]
  10. Jung EG, "Brazilin isolated from Caesalpinia sappan L. inhibits rheumatoid arthritis activity in a type-II collagen induced arthritis mouse model", BMC Complement Altern Med, 15, pp.124~ (2015)[DOI]
  11. Choi DH, "Anti-inflammation activity of brazilin in TNF-α induced human psoriasis dermatitis skin model", Applied Biological Chemistry, 62(5), pp.1~9 (2019)[DOI]
  12. Chatterjee B, "The phytochemical brazilin suppress DNMT1 expression by recruiting p53 to its promoter resulting in the epigenetic restoration of p21 in MCF7cells", Phytomedicine, 95, pp.153885~ (2022)[DOI]
  13. Suyatmi S, "Brazilin Isolated from Caesalpina Sappan Wood Induces Intrinsic Apoptosis on A549 Cancer Cell Line by Increasing p53, caspase-9, and caspase-3", Asian Pac J Cancer Prev, 23(4), pp.1337~1343 (2022)[DOI]
  14. Kang Y, "Brazilin induces FOXO3A-dependent autophagic cell death by disturbing calcium homeostasis in osteosarcoma cells", Cancer Chemother Pharmacol, 82(3), pp.479~491 (2018)[DOI]
  15. Pattananandecha T, "Antibacterial Activity against Foodborne Pathogens and Inhibitory Effect on Anti-Inflammatory Mediators' Production of Brazilin-Enriched Extract from Caesalpinia sappan Linn", Plants(Basel), 11(13), pp.1698~ (2022)[DOI]
  16. Blois MS, "Antioxidant Determinations by the Use of a Stable Free Radical", Nature, 181, pp.1199~1200 (1958)[DOI]
  17. Folin O, "A colorimetric method for the determination of phenols(and phenol derivatives)in urine", J Biol Chem, 22(2), pp.305~308 (1915)[DOI]
  18. Moreno MI, "Comparison of the free radical-scavenging activity of propolis from several regions of Argentina", J Ethnopharmacol, 71(1-2), pp.109~114 (2000)[DOI]
  19. Hong JY, "Study on the Antioxidant Activity of Extracts from the Fruit of Elaeagnus multiflora Thunb", Food Science and Preservation, 13(3), pp.413~419 (2006)
  20. Song WY, "Total Phenols, Flavonoid Contents, and Antioxidant Activity of Spirodela polyrhiza Extracts", Journal of Life Sciences, 27(2), pp.1~ (2017)[DOI]
  21. Park CH, "Antioxidant activity of ethanol extracts and fractions from Castanea crenata inner shell", Journal of Plant Biotechnology, 49(2), pp.150~154 (2022)[DOI]
  22. Park MH, "Antioxidant and Cytotoxic Activities of Hot Water and Ethanol Extracts From Caesalpinia sappan", Korean Society for Industrial Food Engineering, 21(3), pp.249~255 (2017)[DOI]
  23. Lee WH, "Comparison of Physiological Activities of Flammulina velutipes according to Solvent Extractions", J Korean Soc Food Sci Nutr, 47(1), pp.83~89 (2018)[DOI]
  24. Lee ER, "Regulation of Cellular Signal Transduction by Flavonoids", Cancer Prev Res, 12, pp.163~173 (2007)
  25. Jin DH, "Comparison of Bioactivities and Antioxidant Activities of Acai Berry(Euterpe oleracea Mart. )by Different Extraction Solvents", J of Korean Oil Chemists' Soc, 33(4), pp.741~750 (2016)[DOI]
  26. Joo SY, "Antioxidant Activities of Medicinal Plant Extreacts", J korean Soc Food Sci Nutr, 42(4), pp.512~519 (2013)[DOI]
  27. Lee HW, "Antimicrobial Activity of Extracts from Some Traditional Oriental Medicinal Plants against Dental Caries Bacteria", J Dent Hyg Sci, 13(1), pp.45~52 (2013)
  28. LISTIANI B, "ANTIFUNGAL EFFICACY OF SECANG HEARTWOOD (CAESALPINIA SAPPAN L.) SOLUTIONS ON BIOFILMS OF CANDIDA ALBICANS ATCC 10231", Int J Appl Pharma, 11(1) (2019)[DOI]
  29. Shin AR, "Growth inhibition effect of Rubus coreanus Miquel on Candida albicans", J Korean Acad Oral Health, 39(3), pp.168~173 (2015)[DOI]
  30. Cushnie TT, "Antimicrobial activity of flavonoids", Int J Antimicrob Agents, 26(5), pp.343~356 (2005)[DOI]

관련 논문AI추천

치아우식 원인균에 대한 한약재 추출물의 항균효과권현정, 이희원, 한국일, 한만덕, 이푸른하늘한국치위생과학회 · 치위생과학회지2013 · 제13권 제1호소목 추출물의 항균력 및 살균소독력민경진, 이진영한국환경보건학회 · 한국환경보건학회지2011 · 제37권 제2호소목(Caesalpinia sappan L.)의 에틸아세테이트 분획물이 Streptococcus mutans에 대한 항균활성 및 부착 억제권현정, 김용현, 전미애, 한국일, 한만덕한국치위생과학회 · 치위생과학회지2012 · 제12권 제2호가축질병 균주에 대한 소목의 항균활성이성규한국미생물·생명공학회 · 한국미생물·생명공학회지2003 · 제31권 제3호소목으로부터 분리된 Brazilin이 Streptococcus mutans ATCC 25175의 생장에 미치는 효과권현정, 한만덕한국치위생과학회 · 치위생과학회지2012 · 제12권 제3호댓잎 추출물이 구강미생물에 미치는 항산화 및 항균 효과강경희, 김도경, 황혜정한국융합학회 · 한국융합학회논문지2022 · 제13권 제4호

이 간행물의 다른 논문 (8건)

Wnt/β-catenin signaling in cementum formation and homeostasis조의식, 최화정pp. 1-8EAR-2 Expression in Developing Molars in Rats조세용, 김선헌, 김남량, 양동욱pp. 9-17AQP1 expression in the nerve fibers of human tooth pulp박숙경, 김윤숙, 조이슬, 김지만, 배진영, 배용철pp. 19-24Probiotics 섭취 후 구강 마이크로바이옴 변화배현숙, 조아람pp. 25-32Polydatin 처리에 의한 사람치수줄기세포(hDPSCs)의 증식과 분화촉진 효과박봉수, 강해미, 문성혁, 김인령pp. 33-38
원문 보기