본문 바로가기
KERD
논문KCI 등재

산부인과 질환에서 내분비 장애물질의 유전외적 조절: 프탈레이트를 중심으로

Epigenetic control of endocrine disrupting chemicals on gynecological disease: Focused on phthalates

1

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류산부인과학

초록

내분비 장애물질은 생체내에 들어와 호르몬 유사기능을 하는 물질을 의미하는 말로, 많은 종류의 내분비 장애물질들은 대부분 에스트로겐 유사기능을 하거나, 혹은 항에스트로겐 기능을 하는 등, 생식계통을 공격하는 것으로 알려져 있다. 내분비 장애물질은 유전자 변이(genetic variation) 혹은 유전외적 변이(epigenetic variation)를 조절하여 질환을 발생시키는데, 태내에서 노출되는 경우 제3세대까지 영향을준다. 내분비 장애물질은 여러 종류가 있는데, 다이옥신이나 비스페놀 A 등 많은 내분비 장애물질들에 대한 연구가 활발하게 진행되고 있다. 그 중 프탈레이트의 경우 주변에 매우 흔하고 종류가 많아 노출량이 높지만 산부인과 질환에 미치는 영향이 명확하게 밝혀져 있지 않다. 최근 발전되고 있는 유전외적 변이에 대한 연구는 이제까지 밝히지 못했던 내분비 장애물질과 산부인과 질환과의 연관성을 알아내는데 큰 도움이 될 것으로 생각된다.

Abstract

Endocrine disrupting chemicals (EDC) are some chemicals which are acting like hormones inside the body. May kinds of EDCs are acting like estrogen or anti- estrogen, so reproductive systems of male are the main targent organ. EDCs use genetic variations and epigenetic variations as main control route of diseases. When pregnant female is exposed to EDCs, the effects of EDCs on their epigenetic system affect through 3rd generation of offspring. Among many kinds of EDCs, the most notorious EDCs are dioxin and bisphenol A. Phthalates, which have so many kinds and high exposure rate, the effects of phthalate to gynecologic disease were not discovered. So in this paper, we try to summerize the effects of phthalate and new epignetic technique to evalaute the relationship among phthalate and gynecologic disease.

참고문헌 (69)

  1. 이철우, "내분비계장애물질에 대한 이해와 미래 연구방향", Endocrinology and Metabolism, 24(1), pp.7~14 (2009), 대한내분비학회
  2. Newbold R, "Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens", Environ Health Perspect, 103(7), pp.83~87 (1995)
  3. Yang JZ, "Subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates the pathophysiology of endometriosis in the cynomolgus monkey", Toxicol Sci, 56, pp.374~381 (2000)
  4. Cobellis L, "High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis", Hum Reprod, 18, pp.1512~1515 (2003)
  5. Reddy BS, "Association of phthalate esters with endometriosis in Indian women", BJOG, 113, pp.515~520 (2006)
  6. Rasier G, "Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane", Biol Reprod, 77, pp.734~742 (2007)
  7. Howdeshell KL, "Exposure to bisphenol A advances puberty", Nature, 401, pp.763~764 (1999)
  8. Krstevska-Konstantinova M, "Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides", Hum Reprod, 16, pp.1020~1026 (2001)
  9. Blanck HM, "Age at menarche and tanner stage in girls exposed in utero and postnatally to polybrominated biphenyl", Epidemiology, 11, pp.641~647 (2000)
  10. Colón I, "Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development", Environ Health Perspect, 108, pp.895~900 (2000)
  11. Türkyilmaz Z, "A striking and frequent cause of premature thelarche in children: Foeniculum vulgare", J Pediatr Surg, 43, pp.2109~2111 (2008)
  12. Martin OV, "Human health and endocrine disruption: a simple multicriteria framework for the qualitative assessment of end point specific risks in a context of scientific uncertainty", Toxicol Sci, 98, pp.332~347 (2007)
  13. Jenkins S, "Prenatal TCDD exposure predisposes for mammary cancer in rats", Reprod Toxicol, 23, pp.391~396 (2007)
  14. Murray TJ, "Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure", Reprod Toxicol, 23, pp.383~390 (2007)
  15. Vandenberg LN, "Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice", Reprod Toxicol, 26, pp.210~219 (2008)
  16. Caserta D, "Impact of endocrine disruptor chemicals in gynaecology", Hum Reprod Update, 14, pp.59~72 (2008)
  17. Mahoney MM, "Developmental programming: impact of fetal exposure to endocrine-disrupting chemicals on gonadotropin-releasing hormone and estrogen receptor mRNA in sheep hypothalamus", Toxicol Appl Pharmacol, 247, pp.98~104 (2010)
  18. Bellingham M, "Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin", GPR54 system in ovine hypothalamus and pituitary gland, 2009, pp.117, 1556~1562
  19. Dickerson SM, "Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus", Toxicol Appl Pharmacol, 252, pp.36~46 (2011)
  20. Swan SH, "Decrease in anogenital distance among male infants with prenatal phthalate exposure", Environ Health Perspect, 113, pp.1056~1061 (2005)
  21. Kaufman RH, "Structural changes of the genital tract associated with in utero exposure to diethylstilbestrol", Obstet Gynecol Annu, 11, pp.187~202 (1982)
  22. Fowler PA, "Impact of endocrine-disrupting compounds (EDCs) on female reproductive health", Mol Cell Endocrinol, 355, pp.231~239 (2012)
  23. Diamanti-Kandarakis E, "Endocrine-disrupting chemicals: an Endocrine Society scientific statement", Endocr Rev, 30, pp.293~342 (2009)
  24. Parmar D, "Hepatic mixed function oxidases and cytochrome P-450 contents in rat pups exposed to di-(2-ethylhexyl)phthalate through mother’s milk", Drug Metab Dispos, 13, pp.368~370 (1985)
  25. Singh AR, "Maternal-fetal transfer of 14C-di-2-ethylhexyl phthalate and 14C-diethyl phthalate in rats", J Pharm Sci, 64, pp.1347~1350 (1975)
  26. Kremer JJ, "Pharmacokinetics of monobutylphthalate, the active metabolite of di-nbutylphthalate, in pregnant rats", Toxicol Lett, 159, pp.144~153 (2005)
  27. Fennell TR, "Pharmacokinetics of dibutylphthalate in pregnant rats", Toxicol Sci, 82, pp.407~418 (2004)
  28. Kessler W, "Blood burden of di(2-ethylhexyl) phthalate and its primary metabolite mono(2-ethylhexyl) phthalate in pregnant and nonpregnant rats and marmosets", Toxicol Appl Pharmacol, 195, pp.142~153 (2004)
  29. Calafat AM, "Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate", Toxicology, 217, pp.22~30 (2006)
  30. Ema M, "Characterization of developmental toxicity of mono-n-benzyl phthalate in rats", Reprod Toxicol, 10, pp.365~372 (1996)
  31. Saillenfait AM, "Effects of mono-n-butyl phthalate on the development of rat embryos: in vivo and in vitro observations", Pharmacol Toxicol, 89, pp.104~112 (2001)
  32. Ema M, "Teratogenic phase specificity of butyl benzyl phthalate in rats", Toxicology, 79, pp.11~19 (1993)
  33. Singh AR, "Teratogenicity of phthalate esters in rats", J Pharm Sci, 61, pp.51~55 (1972)
  34. Pan G, "Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China", Environ Health Perspect, 114, pp.1643~1648 (2006)
  35. Wormuth M, "What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?", Risk Anal, 26, pp.803~824 (2006)
  36. Lyche JL, "Reproductive and developmental toxicity of phthalates", J Toxicol Environ Health B Crit Rev, 12, pp.225~249 (2009)
  37. Cresteil T, "Onset of xenobiotic metabolism in children: toxicological implications", Food Addit Contam, 15, pp.45~51 (1998)
  38. Agency for Toxic Substances and Disease Registry (ATSDR), "Toxicological profile for di(2-ethylhexyl)phthalate (DEHP)" (2002), U.S. Department of Health and Human Services, Public Health Service
  39. Shea KM; American Academy of Pediatrics Committee on Environmental Health, "Pediatric exposure and potential toxicity of phthalate plasticizers", Pediatrics, 111, pp.1467~1474 (2003)
  40. Sjoberg P, "Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to exchange transfusions", Eur J Clin Invest, 15, pp.430~436 (1985)
  41. Sjoberg PO, "Exposure of newborn infants to plasticizers. Plasma levels of di-(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate during exchange transfusion", Transfusion, 25, pp.424~428 (1985)
  42. Clark K, "Observed concentrations in the environment. In: Staples CA, editor. Phthalate esters, In The handbook of environmental chemistry. Volume 3Q", pp.125~177 (2003), Springer
  43. Kim YH, "Increased viability of endometrial cells by in vitro treatment with di-(2-ethylhexyl) phthalate", Fertil Steril, 94, pp.2413~2416 (2010)
  44. Rossing MA, "Risk of epithelial ovarian cancer in relation to benign ovarian conditions and ovarian surgery", Cancer Causes Control, 19, pp.1357~1364 (2008)
  45. Merritt MA, "Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer", Int J Cancer, 122, pp.170~176 (2008)
  46. Brinton LA, "Relationship of benign gynecologic diseases to subsequent risk of ovarian and uterine tumors", Cancer Epidemiol Biomarkers Prev, 14, pp.2929~2935 (2005)
  47. Fukunaga M, "Ovarian atypical endometriosis: its close association with malignant epithelial tumours", Histopathology, 30, pp.249~255 (1997)
  48. Pearce CL, "Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies", Lancet Oncol, 13, pp.385~394 (2012)
  49. Ness RB, "Endometriosis and ovarian cancer: thoughts on shared pathophysiology", Am J Obstet Gynecol, 189, pp.280~294 (2003)
  50. Kurman RJ, "Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm", Hum Pathol, 42, pp.918~931 (2011)
  51. Wiegand KC, "ARID1A mutations in endometriosis-associated ovarian carcinomas", N Engl J Med, 363, pp.1532~1543 (2010)
  52. Yamaguchi K, "Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress", Clin Cancer Res, 14, pp.32~40 (2008)
  53. "Polycholorinated dibenxo-para-dioxins and polychlorinated dibenxofurans" (2012)[URL]
  54. The january 2001 addendum to the ninth report on carcinogens (originally published May 2000), US HHS, Public Health Service, National Toxicology Program, Research Triangle Park, "National Toxicology Program", ~ (2001)
  55. Meeks JJ, "Environmental toxicology of testicular cancer", Urol Oncol, 30, pp.212~215 (2012)
  56. Yao PL, "Mono-(2-ethylhexyl) phthalate (MEHP) promotes invasion and migration of human testicular embryonal carcinoma cells", Biol Reprod, 86, pp.160~ (2012)
  57. Park MA, "Cell growth of BG-1 ovarian cancer cells is promoted by di-n-butyl phthalate and hexabromocyclododecane via upregulation of the cyclin D and cyclin-dependent kinase-4 genes", Mol Med Report, 5, pp.761~766 (2012)
  58. Campioli E, "The endocrine disruptor mono-(2-ethylhexyl) phthalate affects the differ entiation of human liposarcoma cells (SW 872)", PLoS One, 6, pp.28750~ (2011)
  59. Dolinoy DC, "Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development", Proc Natl Acad Sci U S A, 104, pp.13056~13061 (2007)
  60. Ho SM, "Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4", Cancer Res, 66, pp.5624~5632 (2006)
  61. Newbold RR, "Lessons learned from perinatal exposure to diethylstilbestrol", Toxicol Appl Pharmacol, 199, pp.142~150 (2004)
  62. Alworth LC, "Uterine responsiveness to estradiol and DNA methylation are altered by fetal exposure to diethylstilbestrol and methoxychlor in CD-1 mice: effects of low versus high doses", Toxicol Appl Pharmacol, 183, pp.10~22 (2002)
  63. Zama AM, "Fetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes", Endocrinology, 150, pp.4681~4691 (2009)
  64. Tang WY, "Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein", Endocrinology, 149, pp.5922~5931 (2008)
  65. Anway MD, "Epigenetic transgenerational actions of endocrine disruptors and male fertility", Science, 308, pp.1466~1469 (2005)
  66. Newbold RR, "Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations", Endocrinology, 147, pp.11~17 (2006)
  67. Stouder C, "Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm", Reproduction, 139, pp.373~379 (2010)
  68. Salian S, "Perinatal exposure of rats to Bisphenol A affects the fertility of male offspring", Life Sci, 85, pp.742~752 (2009)
  69. Nilsson EE, "Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease", Reproduction, 135, pp.713~721 (2008)

관련 논문AI추천

이 간행물의 다른 논문 (7건)