Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models
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Abstract
Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs (AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxy-methanol acetate (MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injected control animals. Field potential recordings were used to monitor amplitude and numbers of population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5 mg/kg; phenytoin 40, 60 mg/kg. Diazepam (DZP) and phenytoin (PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration (320 mg/kg, i.p.) with and without pre-treatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.
참고문헌 (49)
- "The place of neuronal migration abnormalities in child neurology", 21(3), pp.185~193 (1994)
- "Development of novel rat mutant with spontaneous limbic-like seizures", 149, pp.329~336 (1996)
- glutamate in rat hippocampal slices, , 1983, 280~284
- "Glutamate receptor mechanisms in human epileptic dysplastic cortex", 32, pp.24~33 (1998)
- "Electrophysiology of CA1 pyramidal neurons in an animal model of neuronal migration disorders", 22(2), pp.145~156 (1995)
- "Flurothyl seizure susceptibility in rats following prenatal methylazoxymetha-nol treatment", 23, pp.189~194 (1996)
- "Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylaxzoxymethanol in utero", 39, pp.87~102 (2000)
- "Disorders of cerebral migration", pp.1~16 (1987)
- "Limbic seizure and brain damage produced by kainic acid mechanisms and relevance to human temporal lobe epilepsy", pp.375~14 403 (1985)
- "Effects of standard anticonvul-sant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices", 859, pp.15~20 (2000)
- "Epileptiform discharges induced by combined application of bicuculline and 4-aminopyridine are resistant to standard anticonvulsants in slices of rats", 268, pp.163~165 (1999)
- "Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy", 22(17), pp.7596~7605 (2002)
- "Hippocampal heterotopia with molecular and electrophysiological pro-perties of neocortical neurons", 114(4), pp.961~972 (2002)
- "The pilocarpine model of epilepsy in mice", 37(10), pp.1015~1019 (1996)
- "Selective ablation of neurons by methylazoxymethanol during pre- and postnatal brain development", pp.103~119 (1986)
- "heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex", 95(17), pp.10263~10268 (1998)
- "Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol", 812, pp.252~255 (1998)
- Ro 15-1788 binding in rat globus pallidus and substantia nigra pars reticulata following a nigrostriatal tract lesion, , 2000, 280~283
- "Methylazoxymethanol (MAMac) effects on ontogenesis of the mouse neocortex.", pp.699~705 (1989)
- "Molecular targets for the myorelaxant action of diazepam", 59(3), pp.442~445 (2001)
- "Seizure susceptibility in immature rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate", 31, pp.109~114 (1995)
- "Hypothetical mechanisms for the cellular and neurophysiologic basis of secondary epilepto-genesis proposed role of synaptic reorganization", 14(2), pp.90~101 (1997)
- "Use of chronic epilepsy models in antiepileptic drug discovery the effect of topiramate on spontaneous motor seizures in rats with kainate-induced epilepsy", 46(1), pp.8~14 (2005)
- "The promise of new antiepileptic drugs", 53(3), pp.123~131 (2002)
- "Hippocampal abnormalities and enhanced excitability in a murine model of human lissencephaly", 20(7), pp.2439~2450 (2000)
- "Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activitity in young and adult rat hippocampus", 12, pp.207~215 (1992)
- "The effects of neuronal migration disorders on seizure susceptibility", pp.~35 (1994)
- "Increased seizure susceptibility in adult rats with neuronal migration disorders", 28, pp.219~222 (1997)
- "Neuronal migration disorders increase susceptibility to hyperthermia-induced seizures in developing rats", 37, pp.902~910 (1996)
- "Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy", 43(4), pp.350~357 (2002)
- "review on drug interactions", 24(1), pp.91~103 (2002)
- "Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate assessment of a rat model of temporal lobe epilepsy", 31(1), pp.73~84 (1998)
- "Surgical treatment of epilepsy due to cortical dysplasia: clinical and EEG findings", ja(ta), pp.765~770 (1993)
- "Granule cell dispersion in the dentate gyrus of human with temporal lobe epilepsy"
- "Actions of maidazolm on excitatory transmission in dorsal horn of adult rat spinal cord", 104(2), pp.338~343 (2006)
- "Drug interactions at GABA(A) receptors", 67(2), pp.113~159 (2002)
- "Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor", pp.356~361 359 (1993)
- "Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs A compa-rison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy", 50, pp.105~123 (2002)
- "Profile of UCB L059 in models of partial and generalized epilepsy in mice and rats", pp.147~158 (1993)
- "Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy", pp.985~34 995 (1993)
- "Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis", 519(3), pp.223~230 (2005)
- "A new benzodiazepine pharmacology", 300(1), pp.2~8 (2002)
- "Focal neuronal migration disorders and intractable partial epilepsy: results of surgical treatment", 30, pp.750~757 (1991)
- "Disorders of cortical development", 13, pp.183~192 (2000)
- "Cortical dysplasiz: a histopathologic study of 52 cases of partial lobectomy in patients with epilepsy", 26, pp.493~500 (1995)
- "GABA(A) receptor subtypes: dissecting their pharmacological functions", 22(4), pp.188~194 (2001)
- "Dysplastic neocortex and subcortical heterotopias in methylazoxymethanol-treated rats an intracellular study of identified pyramidal neurones", 246(3), pp.180~185 (1998)
- "Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia", 50, pp.251~264 (2002)
- "Immunocytochemical investigation on dysplastic human tissue from epileptic patients", 32(1-2), pp.32~48 (1998)
