Comparison of Cognitive Effects of Lamotrigine and Oxcarbazepine in Epilepsy Patients
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Abstract
Background and Purpose: This study compared the cognitive effects of 1 year of treatment with lamotrigine (LTG) and oxcarbazepine (OXC) in epilepsy patients. Methods: This retrospective study investigated 60 epilepsy patients undergoing neuropsychological tests who were either newly diagnosed or untreated in the preceding 6 months. The cognitive function in 30 patients receiving LTG monotherapy and 30 age-matched patients receiving OXC monotherapy was compared after 1 year. The neuropsychological scores at baseline and all of the epilepsy-relevant variables except seizure type did not differ between the groups. The mean daily dosages of LTG and OXC at 1 year were 93 mg and 825 mg, respectively. Results: The posttreatment list-learning performance was better in the LTG group than in the OXC group (p<0.05). The incidence of cognitive complaints did not differ between the two groups. The list-learning performance and Trail Making Test scores were better in each group after treatment. Conclusions: LTG and OXC monotherapies have similar, slightly beneficial effects on cognitive function, and are probably not harmful.
참고문헌 (42)
- "Sicuteri F. Hyperresponsiveness of migraine patients to the hypotensive action of bromocriptine. Headache 1980", pp.99~102
- Guell A, "Bes A. Clinical value of a dopaminergic agonist administration in migraine patients. Headache 1983"
- David J, "Rascol A. Does the piribedil test permit predicting the efficacy of domperidone in the treatment of migraine? Headache 1985", pp.332~333
- Bes A, "Geraud G. Pharmacological exploration of dopamine hypersensitivity in migraine patients. Int J Clin Pharmacol Res 1986"
- Welch KMA, "Brown E. Event-related slow potentials and associated catecholamine function in migraine. Cephalalgia 1990", pp.317~329
- Fisher H, "A new approach to emergency department therapy of migraine headache with intravenous haloperidol: a case series", 13, pp.119~122 (1995)
- Emilien G, "receptors-physiological understanding to therapeutic intervention potential", 84, pp.133~156 (1999)
- Mascia A, "Dopamine and migraine: a review of pharmacological, biochemical, neurophysiological, and therapeutic data", 18, pp.174~182 (1998)
- Cerbo R, "Dopamine hypersensitivity in migraine: role of the apomorphine test", 20, pp.36~41 (1997)
- Sicuteri F. Dopamine, "the second putative protagonist in headache. Headache 1977", pp.129~131
- Honkasalo ML, "Migraine and concomitant symptoms among 8167 adult twin pairs", 35, pp.70~78 (1995)
- Larsson B, "Genetic influence in headaches: a Swedish twin study", 35, pp.513~519 (1995)
- Russell MB, "Olesen J. The genetics of migraine without aura and migraine with aura. Cephalalgia 1993", pp.245~248
- Lachman HM, "Association of codon 108", 158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome, 1996, pp.67, 468~472
- Strous RD, "Lack of association of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia", 41, pp.493~495 (1997)
- Syvanen AC, "Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S- COMT activity and comparison of the allele frequencies in the normal population and parkinsonian patients in Finland", 7, pp.65~71 (1997)
- Daniels JK, "No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol-O-methyltransferase activity", 153, pp.268~270 (1996)
- Lachman HM, "Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders", 6, pp.243~250 (1996)
- Papolos DF, "Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele", 3, pp.346~349 (1998)
- Ermin Erdal M, "Significance of the catechol-O-methyltransferase gene polymorphism in migraine", 94, pp.193~196 (2001)
- Headache classification subcommittee of the international headache society, "The international classification of headache disorders. 2nd Edn", 24(Suppl), pp.1~160
- Peroutka SJ, "Dopamine and migraine", 49, pp.650~656 (1997)
- Peroutka SJ, "Clinical susceptibility to migraine with aura is modified by dopamine D2 receptor (DRD2) NcoI alleles", 49, pp.201~206 (1997)
- Del Zompo M, "Association between dopamine receptor genes and migraine without aura in a Sardinian sample", 51, pp.781~786 (1998)
- Dichgans M, "The D2 receptor NcoI allele: absence of allelic association with migraine with aura", 51, pp.928~ (1998)
- Lea RA, "Evidence for allelic association of the dopamine beta-hydroxylase gene (DBH) with susceptibility to typical migraine", 3, pp.35~40 (2000)
- Shepherd AG, "Dopamine receptor genes and migraine with and without aura: an association study", 42, pp.346~351 (2002)
- Mochi M, "A genetic association study of migraine with dopamine receptor 4, dopamine transporter and dopamine-beta-hydroxylase genes", 23, pp.301~305 (2003)
- Filic V, "Monoamine oxidases A and B gene polymorphisms in migraine patients", 15, pp.149~153 (2005)
- Marziniak M, "Association analysis of the functional monoamine oxidase A gene promotor polymorphism in migraine", 111, pp.603~609 (2004)
- Tiihonen J, "Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism", 4, pp.286~289 (1999)
- Kauhanen J, "Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers", 24, pp.135~159 (2000)
- Hallikainen T, "Lack of association between the functional variant of the catechol-O-methyltransferase (COMT) gene and early-onset alcoholism associated with severe antisocial behavior", 96, pp.348~352 (2000)
- Ishiguro H, "Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholism", 9, pp.135~138 (1999)
- Chudler EH, "The role of the basal ganglia in nociception and pain", 60, pp.3~38 (1995)
- "Paalzow GH. L-dopa induces opposing effects on pain in intact rats SCH 23390 or alpha-methyl-DL- p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses. J Pharmacol Exp Ther 1992", pp.470~479
- Silberstein SD, "Acute migraine treatment with droperidol: a randomized, double-blind, placebo-controlled trial", 60, pp.315~321 (2003)
- Wang SJ, "Droperidol treatment of status migrainosus and refractory migraine", 37, pp.377~382 (1997)
- Hyde TM, "Distribution of dopamine D1-D4 receptor subtypes in human dorsal vagal complex", 24, pp.224~232 (1996)
- Kohli JD, "Goldberg LI. Selective DA2 versus DA1 antagonist activity of domperidone in the periphery. Eur J Pharmacol 1983", pp.137~141
- Pietrini U, "myth and facts about basilar artery migraine. In", pp.147~160 (1985)
- Nakamura A, "Association between catechol-O-methyltransferase (COMT) polymorphism and severe alcoholic withdrawal symptoms in male Japanese alcoholics", 6, pp.233~238 (2001)
