Boron delivery systems for enhanced boron neutron capture therapy: a comprehensive review
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Boron neutron capture therapy (BNCT) is a promising cancer-treatment strategy that involves the induction of nuclear fission reactions via the interaction of low-energy thermal neutrons with boron (10B), enabling selective tumor-cell apoptosis. For BNCT to be effective, achieving a high degree of localization of 10B atoms within the tumor cells is crucial. Currently, the clinical use of the two U.S. Food and Drug Administration (FDA)-approved drugs for BNCT, sodium mercaptoundecahydro-closo-dodecaborate (BSH) and boronophenylalanine (BPA), is restricted by their low uptake and low tumor-to-blood selectivity. Ongoing efforts are focused on developing high-uptake boron delivery agents with pharmacokinetic characteristics that enable high-efficiency BNCT. This review provides a comprehensive overview of the recent developments in boron delivery strategies for BNCT.
Abstract
Boron neutron capture therapy (BNCT) is a promising cancer-treatment strategy that involves the induction of nuclear fission reactions via the interaction of low-energy thermal neutrons with boron (10B), enabling selective tumor-cell apoptosis. For BNCT to be effective, achieving a high degree of localization of 10B atoms within the tumor cells is crucial. Currently, the clinical use of the two U.S. Food and Drug Administration (FDA)-approved drugs for BNCT, sodium mercaptoundecahydro-closo-dodecaborate (BSH) and boronophenylalanine (BPA), is restricted by their low uptake and low tumor-to-blood selectivity. Ongoing efforts are focused on developing high-uptake boron delivery agents with pharmacokinetic characteristics that enable high-efficiency BNCT. This review provides a comprehensive overview of the recent developments in boron delivery strategies for BNCT.
참고문헌 (44)
- Locher G, "Biological effects and therapeutic possibilities of neutrons", Am J Roentgenol, 36, pp.1~13 (1936)
- Suzuki M, "Boron neutron capture therapy(BNCT) : a unique role in radiotherapy with a view to entering the acceleratorbased BNCT era", Int J Clin Oncol, 25, pp.43~50 (2020)
- Hu K, "Boron agents for neutron capture therapy", Coord Chem Rev, 405, pp.213139~ (2020)
- Malouff TD, "Boron neutron capture therapy : a review of clinical applications", Front Oncol, 11, pp.601820~ (2021)
- Choi G, "Highly condensed boron cage cluster anions in 2D carrier and its enhanced antitumor efficiency for boron neutron capture therapy", Adv Funct Mater, 28, pp.1704470~ (2018)
- Dai Q, "The development of boron analysis and imaging in boron neutron capture therapy(BNCT)", Mol Pharm, 19, pp.363~377 (2022)
- Paolo Coghi, "Next generation of boron neutron capture therapy (BNCT) agents for cancer treatment", Medicinal Research Reviews, 43(5), pp.1809~1830 (2023), Wiley[DOI]
- Dymova MA, "Boron neutron capture therapy : current status and future perspectives", Cancer Commun(Lond), 40, pp.406~421 (2020)
- Mi P, "Block copolymer-boron cluster conjugate for effective boron neutron capture therapy of solid tumors", J Control Release, 254, pp.1~9 (2017)
- Hoppenz P, "Peptide-drug conjugates and their targets in advanced cancer therapies", Front Chem, 8, pp.571~ (2020)
- Lee W, "PEGylated liposome encapsulating nido-carborane showed significant tumor suppression in boron neutron capture therapy(BNCT)", Biochem Biophys Res Commun, 522, pp.669~675 (2020)
- Ay AN, "Carborane-layered double hydroxide nanohybrids for potential targeted-and magnetically targeted-BNCT applications", Dalton Trans, 46, pp.3303~3310 (2017)
- Alberti D, "Synthesis of a carborane-containing cholesterol derivative and evaluation as a potential dual agent for MRI", BNCT applications, 2014, pp.12, 2457~2467
- Zargham EO, "The use of carboranes in cancer drug development", Int J Cancer Clin Res, 6, pp.110~ (2019)
- Zhu Y, "Boron drug delivery via encapsulated magnetic nanocomposites : a new approach for BNCT in cancer treatment", J Nanomater, 2010, pp.409320~ (2010)
- Nakase I, "Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy(BNCT)", Chem Commun(Camb), 55, pp.13955~13958 (2019)
- Nakamura H, "Neutron Capture Therapy: Principles and Applications", pp.99~116 (2012), Springer
- Stadlbauer S, "Biscarbaborane-bridged bis-glycophosphonates as boron-rich delivery agents for BNCT", Eur J Org Chem, 2010, pp.3129~3139 (2010)
- Soloway AH, "Penetration of brain and brain tumor. VII. Tumor-binding sulfhydryl boron compounds", J Med Chem, 10, pp.714~717 (1967)
- Nakase I, "Antibody-based receptor targeting using an Fc-binding peptide-dodecaborate conjugate and macropinocytosis induction for boron neutron capture therapy", ACS Omega, 5, pp.22731~22738 (2020)
- Hirase S, "Dodecaborate-encapsulated extracellular vesicles with modification of cell-penetrating peptides for enhancing macropinocytotic cellular uptake and biological activity in boron neutron capture therapy", Mol Pharm, 19, pp.1135~1145 (2022)
- Michiue H, "Self-assembling A6K peptide nanotubes as a mercaptoundecahydrododecaborate(BSH)delivery system for boron neutron capture therapy(BNCT)", J Control Release, 330, pp.788~796 (2021)
- Laird M, "Organosilica nanoparticles containing sodium borocaptate(BSH)provide new prospects for boron neutron capture therapy(BNCT) : efficient cellular uptake and enhanced BNCT efficacy", Nanoscale Adv, 5, pp.2537~2546 (2023)
- Coninx S, "Tailored hyaluronic acid-based nanogels as theranostic boron delivery systems for boron neutron cancer therapy", Int J Pharm X, 4, pp.100134~ (2022)
- Takeuchi K, "Synthesis and evaluation of dodecaboranethiol containing kojic acid(KA-BSH)as a novel agent for boron neutron capture therapy", Cells, 9, pp.1551~ (2020)
- Mishima Y, "First human clinical trial of melanoma neutron capture. Diagnosis and therapy", Strahlenther Onkol, 165, pp.251~254 (1989)
- Seo IH, "The antitumor effect of boron neutron capture therapy in glioblastoma subcutaneous xenograft model using the proton linear accelerator-based BNCT system in Korea", Life(Basel), 12, pp.1264~ (2022)
- Kusaka S, "Boron delivery to brain cells via cerebrospinal fluid(CSF)circulation for BNCT in a rat melanoma model", Biology(Basel), 11, pp.397~ (2022)
- Nomoto T, "Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy", J Control Release, 332, pp.184~193 (2021)
- Diaz AZ, "Assessment of the results from the phase I", II boron neutron capture therapy trials at the Brookhaven National Laboratory from a clinician’s point of view, 2003, pp.62, 101~109
- Arima J, "Anti-tumor effect of boron neutron capture therapy in pelvic human colorectal cancer in a mouse model", Biomed Pharmacother, 154, pp.113632~ (2022)
- Terada S, "Boron uptake of boronophenylalanine and the effect of boron neutron capture therapy in cervical cancer cells", Appl Radiat Isot, 197, pp.110792~ (2023)
- Nomoto T, "Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism", Sci Adv, 6, pp.eaaz1722~ (2020)
- Dai L, "BPA-containing polydopamine nanoparticles for boron neutron capture therapy in a U87 glioma orthotopic model", Adv Funct Mater, 33, pp.2214145~ (2023)
- Tamanoi F, "Construction of boronophenylalanine-loaded biodegradable periodic mesoporous organosilica nanoparticles for BNCT cancer therapy", Int J Mol Sci, 22, pp.2251~ (2021)
- Wu Y, "High thermally stable thermosetting polyimides derived from a carborane-containing tetramine", High Perform Polym, 31, pp.548~556 (2019)
- Morgan DA, "Direct imaging of o-carborane molecules within single walled carbon nanotubes", Chem Commun(Camb), (20), pp.2442~2443 (2002)
- Zhang T, "Chitosanlactobionic acid-thioctic acid-modified hollow mesoporous silica composite loaded with carborane for boron neutron capture therapy of hepatocellular carcinoma", Mater Des, 223, pp.111196~ (2022)
- Alamón C, "A potential boron neutron capture therapy agent selectively suppresses high-grade glioma : in vitro and in vivo exploration", Mol Pharm, 20, pp.2702~2713 (2023)
- Yang Q, "Evaluation of a tumor-targeting oligosaccharide nanosystem in BNCT on an orthotopic hepatocellular carcinoma model", Mol Pharm, 20, pp.1025~1038 (2023)
- Sforzi J, "A novel pH sensitive theranostic PLGA nanoparticle for boron neutron capture therapy in mesothelioma treatment", Sci Rep, 13, pp.620~ (2023)
- Li J, "Boron encapsulated in a liposome can be used for combinational neutron capture therapy", Nat Commun, 13, pp.2143~ (2022)
- Shi Y, "Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy", Nat Commun, 14, pp.1884~ (2023)
- Chen J, "Therapeutic nucleus-access BNCT drug combined CD47-targeting gene editing in glioblastoma", J Nanobiotechnology, 20, pp.102~ (2022)
