페니실린 농도 검출을 위한 광지시형 전위차 센서의 제작 및 감응특성
Fabrication and Response Characteristics of the Light Addressable Potentiometric Sensor for Detecting the Penicillin Concentration
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Abstract
In this study, we developed the measuring system based on light addressable potentiometric sensor for the quantitative analysis of penicillin that is very important element in medicine and pharmacy, clinic. It is investigated the response characteristics by enzyme reaction with penicillinase. First, the surface pre-treatment process of the Si3N4 was established. The coupling agent was made using self assembled monolayer method and it was confirmed the immobilization process by AFM. Also, as the measuring system, potentiostat, signal processing part etc. was made by LabVIEW software, it was reduced detecting time as well as simplifying the system. Fabricated device was shown excellent pH response characteristics, 57 mV/pH in the range of pH 2～11. The response characteristics was 60 mV/decade in the range of 0.1 mM ～10 mM.
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