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Treatment of Oral Buccal Cancer in a Patient with Fanconi Anemia: A Case Report and Literature Review

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주제분류이비인후과학

초록

Fanconi anemia (FA) is a rare genetic disease associated with abnormalities such as bone marrow failure, growth delay, and susceptibility to cancer. Head and neck squamous cell carcinoma (HNSCC) is the most common solid cancer among FA patients; indeed, the incidence is >500-fold higher than that in the general population. HNSCC in FA patients has a different etiology, clinical course, and prognosis from that in the general population. Here, we describe a case of buccal cancer in a patient with FA, and report treatment details and challenges, along with a literature review.

Abstract

Fanconi anemia (FA) is a rare genetic disease associated with abnormalities such as bone marrow failure, growth delay, and susceptibility to cancer. Head and neck squamous cell carcinoma (HNSCC) is the most common solid cancer among FA patients; indeed, the incidence is >500-fold higher than that in the general population. HNSCC in FA patients has a different etiology, clinical course, and prognosis from that in the general population. Here, we describe a case of buccal cancer in a patient with FA, and report treatment details and challenges, along with a literature review.

참고문헌 (12)

  1. Velleuer E, "Fanconi anemia : young patients at high risk for squamous cell carcinoma", Mol Cell Pediatr, 1(1), pp.9~ (2014)
  2. Nalepa G, "Fanconi anaemia and cancer : an intricate relationship", Nat Rev Cancer, 18(3), pp.168~185 (2018)
  3. Kavak G, "A case of hypopharyngeal cancer associated with Fanconi anemia : a helical tomotherapy experience", Cureus, 13(11), pp.e19386~ (2021)
  4. Rosenberg PS, "Cancer incidence in persons with Fanconi anemia", Blood, 101(3), pp.822~826 (2003)
  5. Lee RH, "Treatment of Fanconi anemia–associated head and neck cancer : opportunities to improve outcomes", Clin Cancer Res, 27(19), pp.5168~5187 (2021)
  6. Guardiola P, "Acute graft-versus-host disease in patients with Fanconi anemia or acquired aplastic anemia undergoing bone marrow transplantation from HLA-identical sibling donors : risk factors and influence on outcome", Blood, 103(1), pp.73~77 (2004)
  7. Kutler DI, "High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia", Arch Otolaryngol Head Neck Surg, 129(1), pp.106~112 (2003)
  8. de Araujo MR, "High prevalence of oral human papillomavirus infection in Fanconi’s anemia patients", Oral Dis, 17(6), pp.572~576 (2011)
  9. Masserot C, "Head and neck squamous cell carcinoma in 13 patients with Fanconi anemia after hematopoietic stem cell transplantation", Cancer, 113(12), pp.3315~3322 (2008)
  10. Best DL, "Squamous cell carcinoma of the tongue in young patients : a case series and literature review", J Oral Maxillofac Surg, 79(6), pp.1270~1286 (2021)
  11. Lee SH, "Treatment of tongue cancer in patient with Fanconi’s anemia", Korean J Otorhinolaryngol Head Neck Surg, 60(9), pp.467~470 (2017)
  12. Deng S, "Oral tongue cancer in a patient with Fanconi anemia : a case report and literature review", Cancer Manag Res, 13, pp.3145~3154 (2021)

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