Management and treatment of four cases of oral carcinoma cuniculatum
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Objectives: Oral carcinoma cuniculatum (OCC) is a rare variant of squamous cell carcinoma (SCC). It has similar clinicopathological characteristics to SCC and verrucous carcinoma (VC). We present a case series of OCC and analyse its unique features, diagnosis, and management. Patients and Methods: We retrospectively reviewed the medical records of oral cancer patients treated by Oral and Maxillofacial Surgery department from 2009 to 2020 with OCC biopsy findings. The clinicopathological characteristics and management of the OCC cases were analysed. Results: Four patients were identified with histologic findings of OCC, including three on the alveolar ridge mucosa and one on the tongue. Imaging revealed that two of the lesions located in the maxilla had osseous lysis. All four patients were all treated with radical excision, and the histopathology showed findings of SCC cuniculatum. It was decided that no further treatment was necessary. None of the patients has experienced recurrence during follow-up. Conclusion: OCC is a distinct entity that is more locally aggressive than VC but is associated with good prognosis. Radical surgical removal is considered appropriate for OCC. Emphasis should be given on an early diagnosis, as it remains challenging.
Abstract
Objectives: Oral carcinoma cuniculatum (OCC) is a rare variant of squamous cell carcinoma (SCC). It has similar clinicopathological characteristics to SCC and verrucous carcinoma (VC). We present a case series of OCC and analyse its unique features, diagnosis, and management. Patients and Methods: We retrospectively reviewed the medical records of oral cancer patients treated by Oral and Maxillofacial Surgery department from 2009 to 2020 with OCC biopsy findings. The clinicopathological characteristics and management of the OCC cases were analysed. Results: Four patients were identified with histologic findings of OCC, including three on the alveolar ridge mucosa and one on the tongue. Imaging revealed that two of the lesions located in the maxilla had osseous lysis. All four patients were all treated with radical excision, and the histopathology showed findings of SCC cuniculatum. It was decided that no further treatment was necessary. None of the patients has experienced recurrence during follow-up. Conclusion: OCC is a distinct entity that is more locally aggressive than VC but is associated with good prognosis. Radical surgical removal is considered appropriate for OCC. Emphasis should be given on an early diagnosis, as it remains challenging.
참고문헌 (22)
- Kruse AL, "Carcinoma cuniculatum : a rare entity in the oral cavity", J Craniofac Surg, 20, pp.1270~1272 (2009)[DOI]
- Aird I, "Epithelioma cuniculatum : a variety of squamous carcinoma peculiar to the foot", Br J Surg, 42, pp.245~250 (1954)[DOI]
- Goh GH, "Carcinoma cuniculatum of the esophagus and tongue : report of two cases, including TP53 mutational analysis", Head Neck Pathol, 8, pp.261~268 (2014)[DOI]
- Lawrence-Brown MM, "Carcinoma cuniculatum of the abdominal wall", Med J Aust, 140, pp.668~669 (1984)[DOI]
- Barreto JE, "Carcinoma cuniculatum : a distinctive variant of penile squamous cell carcinoma : report of 7 cases", Am J Surg Pathol, 31, pp.71~75 (2007)[DOI]
- Smyth M, "Carcinoma cuniculatum of the cervix", Pathology, 46, pp.353~355 (2014)[DOI]
- Kunc M, "Carcinoma cuniculatum of the lower leg : a case report and proposed diagnostic criteria", Am J Dermatopathol, 41, pp.855~857 (2019)[DOI]
- Shenoy AS, "Carcinoma cuniculatum of foot", Foot(Edinb), 21, pp.207~208 (2011)[DOI]
- DʼAniello C, "Verrucous ʻcuniculatumʼ carcinoma of the sacral region", Br J Dermatol, 143, pp.459~460 (2000)[DOI]
- Flieger S, "Epithelioma cuniculatum an unusual form of mouth and jaw neoplasm", Czas Stomatol, 30, pp.395~401 (1977)
- Farag AF, "Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma : a systematic review", Imaging Sci Dent, 48, pp.233~244 (2018)[DOI]
- Sun Y, "Clinicopathological evaluation of carcinoma cuniculatum : a variant of oral squamous cell carcinoma", J Oral Pathol Med, 41, pp.303~308 (2012)[DOI]
- Thavaraj S, "Carcinoma cuniculatum arising in the tongue", Head Neck Pathol, 6, pp.130~134 (2012)[DOI]
- Sepúlveda I, "Maxillary cuniculatum carcinoma : a case report and literature review", Int J Odontostomatol, 6, pp.281~284 (2012)[DOI]
- Pons Y, "Mandibular cuniculatum carcinoma : apropos of 3 cases and literature review", Head Neck, 34, pp.291~295 (2012)[DOI]
- Devaney KO, "Verrucous carcinoma(carcinoma cuniculatum)of the head and neck : what do we know now that we did not know a decade ago?", Eur Arch Otorhinolaryngol, 268, pp.477~480 (2011)[DOI]
- Barrett AW, "Cystic squamous cell carcinomas of the jaws : twelve cases highlighting histopathological pitfalls", Int J Surg Pathol, 28, pp.624~630 (2020)[DOI]
- Hutton A, "Oral carcinoma cuniculatum in a young child", J Clin Pediatr Dent, 35, pp.89~94 (2010)[DOI]
- Allon D, "Carcinoma cuniculatum of the jaw : a rare variant of oral carcinoma", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 94, pp.601~608 (2002)[DOI]
- Padilla RJ, "Carcinoma cuniculatum of the oral mucosa : a potentially underdiagnosed entity in the absence of clinical correlation", Oral Surg Oral Med Oral Pathol Oral Radiol, 118, pp.684~693 (2014)[DOI]
- Thompson L, "World Health Organization classification of tumours : pathology and genetics of head and neck tumours", Ear Nose Throat J, 85, pp.74~ (2006)
- Suzuki J, "Carcinoma cuniculatum mimicking leukoplakia of the mandibular gingiva", Auris Nasus Larynx, 39, pp.321~325 (2012)[DOI]