Arsenic Toxicity in Male Reproduction and Development
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Arsenic is a toxic metalloid that exists ubiquitously in the environment, and affects global health problems due to its carcinogenicity. In most populations, the main source of arsenic exposure is the drinking water. In drinking water, chronic exposure to arsenic is associated with increased risks of various cancers including those of skin, lung, bladder, and liver, as well as numerous other non-cancer diseases including gastrointestinal and cardiovascular diseases, diabetes, and neurologic and cognitive problems. Recent emerging evidences suggest that arsenic exposure affects the reproductive and developmental toxicity. Prenatal exposure to inorganic arsenic causes adverse pregnancy outcomes and children’s health problems. Some epidemiological studies have reported that arsenic exposure induces premature delivery, spontaneous abortion, and stillbirth. In animal studies, inorganic arsenic also causes fetal malformation, growth retardation, and fetal death. These toxic effects depend on dose, route and gestation periods of arsenic exposure. In males, inorganic arsenic causes reproductive dysfunctions including reductions of the testis weights, accessory sex organs weights, and epididymal sperm counts. In addition, inorganic arsenic exposure also induces alterations of spermatogenesis, reductions of testosterone and gonadotrophins, and disruptions of steroidogenesis. However, the reproductive and developmental problems following arsenic exposure are poorly understood, and the molecular mechanism of arsenic-induced reproductive toxicity remains unclear. Thus, we further investigated several possible mechanisms underlying arsenic-induced reproductive toxicity.
Abstract
Arsenic is a toxic metalloid that exists ubiquitously in the environment, and affects global health problems due to its carcinogenicity. In most populations, the main source of arsenic exposure is the drinking water. In drinking water, chronic exposure to arsenic is associated with increased risks of various cancers including those of skin, lung, bladder, and liver, as well as numerous other non-cancer diseases including gastrointestinal and cardiovascular diseases, diabetes, and neurologic and cognitive problems. Recent emerging evidences suggest that arsenic exposure affects the reproductive and developmental toxicity. Prenatal exposure to inorganic arsenic causes adverse pregnancy outcomes and children’s health problems. Some epidemiological studies have reported that arsenic exposure induces premature delivery, spontaneous abortion, and stillbirth. In animal studies, inorganic arsenic also causes fetal malformation, growth retardation, and fetal death. These toxic effects depend on dose, route and gestation periods of arsenic exposure. In males, inorganic arsenic causes reproductive dysfunctions including reductions of the testis weights, accessory sex organs weights, and epididymal sperm counts. In addition, inorganic arsenic exposure also induces alterations of spermatogenesis, reductions of testosterone and gonadotrophins, and disruptions of steroidogenesis. However, the reproductive and developmental problems following arsenic exposure are poorly understood, and the molecular mechanism of arsenic-induced reproductive toxicity remains unclear. Thus, we further investigated several possible mechanisms underlying arsenic-induced reproductive toxicity.
참고문헌 (108)
- Abernathy CO, "Health effects and risk assessment of arsenic", J Nutr, 133(suppl 1), pp.1536S~1538S (2003)
- Ahmad SA, "Arsenic in drinking water and pregnancy outcomes", Environ Health Perspect, 109, pp.629~631 (2001)
- Ahmed S, "Arsenic-associated oxidative stress, inflammation, and immune disruption in human placenta and cord blood", Environ Health Perspect, 119, pp.258~264 (2011)
- Akter KF, "Arsenic speciation and toxicity in biological systems", Rev Environ Contam Toxicol, 184, pp.97~149 (2005)
- Aposhian HV, "Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity", Ann Rev Pharmacol Toxicol, 37, pp.397~419 (1997)
- Toxicological Profile for Arsenic, "ATSDR", U.S. Department of Health and Human Services. Public Health Service, ~, pp.ATSDR (1989), TP-88[DOI]
- Toxicological Profile for Arsenic, "ATSDR", U.S. Department of Health and Human Services, Public Health Service, ~ (2007)
- Biswas NM, "Effect of sodium arsenite on adrenocortical activities in male rats: Dose-duration dependent responses", Med Sci Res, 23, pp.153~154 (1994)
- Byron WR, "Pathological changes in rates and dogs from two year feeding of sodium arsenite or sodium arsenate", Toxicol Appl Pharmacol, 10, pp.132~147 (1967)
- Celino FT, "Arsenic inhibits in vitro spermatogenesis and induces germ cell apoptosis in Japanese eel (Anguilla japonica)", Reproduction, 138, pp.279~287 (2009)
- Chakraborti D, "Arsenic groundwater contamination in Middle Ganga Plain, Bihar, India: a future danger?", Environ Health Perspect, 111, pp.1194~1201 (2003)
- Chang SI, "Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis", Toxicol Appl Pharmacol, 218, pp.196~203 (2007)
- Chattopadhyay S, "Arsenic induced changes in growth development and apoptosis in neonatal and adult brain cells in vivo and in tissue culture", Toxicol Lett, 128, pp.73~84 (2002)
- Chattopadhyay S, "Effect of sodium arsenite on plasma levels of gonadotrophins and ovarian steroidogenesis in mature albino rats: duration dependent response", J Toxicol Sci, 24, pp.425~431 (1999)
- Chernoff N, "Effects of chemically induced maternal toxicity on prenatal development in the rat", Teratology, 42, pp.651~658 (1990)
- Chinoy NJ, "Fluoride and", or arsenic toxicity in mice testis with formation of giant cells and subsequent recovery by some antidotes, 2004, pp.37, 172~184
- Cohen SM, "Methylated arsenicals: The implications of metabolism and carcinogenicity studies in rodents to human risk assessment", Crit Rev Toxicol, 36, pp.99~133 (2006)
- Concha G, "Exposure to inorganic arsenic metabolites during early human development", Toxicol Sci, 44, pp.185~190 (1998)
- Crecelius EA, "Changes in the chemical speciation of arsenic following ingestion by man", Environ Health Perspect, 19, pp.147~150 (1977)
- Cullen WR, "Arsenic speciation in the environment", Chem Rev, 89, pp.713~774 (1989)
- Danielsson BR, "Accumulation of toxic metals in male reproduction organs", Arch Toxicol Suppl, 7, pp.177~180 (1984)
- Davila-Esqueda ME, "Effects of arsenic exposure during the pre- and postnatal development on the puberty of female offspring", Exp Toxicol Pathol, 64, pp.25~30 (2012)
- DeSesso JM, "Teratogen update: Inorganic arsenic", Teratology, 64, pp.170~173 (2001)
- Dopp E, "Uptake of inorganic and organic derivatives of arsenic associated with induced cytotoxic and genotoxic effects in Chinese hamster ovary (CHO) cells", Toxicology and Applied Pharmacology, 201, pp.156~165 (2004)
- Dopp E, "Forced uptake of trivalent and pentavalent methylated and inorganic arsenic and its cyto-", genotoxicity in fibroblasts and hepatoma cells, 2005, pp.87, 46~56
- Douer D, "Arsenic trioxide: new clinical experience with an old medication in hematologic malignancies", J Clin Oncol, 23, pp.2396~2410 (2005)
- Drobna Z, "Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase", Toxicol Appl Pharmacol, 207, pp.147~159 (2005)
- Fascineli ML, "Fetotoxicity caused by the interaction between zinc and arsenic in mice", Teratog Carcinog Mutagen, 22, pp.315~327 (2002)
- Ferm VH, "Malformations induced by sodium arsenate", J Reprod Fertil, 17, pp.199~201 (1968)
- Fry RC, "Activation of inflammation", NF-kappaB signaling in infants born to arsenic-exposed mothers, 2007, pp.3, e207~
- Ghosh D, "Effect of sodium arsenite on adrenocortical activity in immature female rats: Evidence of dose-dependent response", J Environ Sci, 11, pp.419~422 (1999)
- Goebl HH, "Polyneuropathy due to arsenic intoxication: biopsy studies", J Neurol, 49, pp.137~149 (1990)
- Golub MS, "Developmental and reproductive toxicity of inorganic arsenic: animal studies and human concerns", J Toxicol Environ Health B Crit Rev, 1, pp.199~241 (1998)
- Griswold MD, "The central role of Sertoli cells in spermatogenesis", Semin Cell Dev Biol, 9, pp.411~416 (1998)
- Hall M, "Determinants of arsenic metabolism: Blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs", Environ Health Perspect, 115, pp.1503~1509 (2007)
- Hardy MP, "Stress hormone and male reproductive function", Cell Tissue Res, 322, pp.147~153 (2005)
- Healy SM, "Enzymatic methylation of arsenic compounds. V. Arsenite methyltransferase activity in tissue of mice", Toxicol Appl Pharmacol, 148, pp.65~70 (1998)
- Holson JF, "Appropriate use of animal models in the assessment of risk during prenatal development: An illustration using inorganic arsenic", Teratology, 62, pp.51~71 (2000)
- Holson JF, "Evaluation of the prenatal developmental toxicity of orally administered arsenic trioxide in rats", Food Chem Toxicol, 38, pp.459~466 (2000)
- Holson JF, "Absence of prenatal developmental toxicity from inhaled arsenic trioxide in rats", Toxicol Sci, 51, pp.87~97 (1999)
- Hood RD, "Teratogenic effects of sodium arsenate in mice", Arch Environ Health, 24, pp.62~65 (1972)
- Hood RD, "Distribution, metabolism, and fetal uptake of pentavalent arsenic in pregnant mice following oral or intraperitoneal administration", Teratology, 35, pp.19~25 (1987)
- Hopenhayn-Rich C, "Chronic arsenic exposure and risk of infant mortality in two areas of Chile", Environ Health Perspect, 108, pp.667~673 (2000)
- Hopenhayn C, "Arsenic exposure from drinking water and birth weight", Epidemiology, 14, pp.593~602 (2003)
- Hsieh FI, "Risk of erectile dysfunction induced by arsenic exposure through well water consumption in Taiwan", Environ Health Perspect, 116, pp.532~536 (2008)
- Hu J, "Long-term survival and prognostic study in acute promyelocytic leukemia treated with all-transretinoic acid, chemotherapy, and As2O3: an experience of 120 patients at a single institution", Int J Hematol, 70, pp.248~260 (1999)
- Huff J, "Is the human carcinogen arsenic carcinogenic to laboratory animals", Toxicol Sci, 55, pp.17~23 (2000)
- Hunter FT, "Radioactive tracer studies on arsenic injected as potassium arsenite", J Pharmacol Exp Ther, 76, pp.207~220 (1942)
- IARC, "Some metals and metallic compounds. IARC Monogr Eval Carcinog Risk Chem Hum, Lyon, 23", pp.1~415 (1980)
- IARC, "Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42. IARC Monogr Eval Carcinog Risks Hum Suppl, Lyon, 7", pp.1~440 (1987)
- IARC, "Some drinking-water disinfectants and contaminants, including arsenic. IARC Monogr Eval Carcinog Risks Hum, Lyon, 84", pp.1~477 (2004)
- Ihrig MM, "A hospital-based case-control study of stillbirths and environmental exposure to arsenic using an atmospheric dispersion model linked to a geographical information system", Epidemiology, 9, pp.290~294 (1998)
- Jana K, "Effects of chronic exposure to sodium arsenite on hypothalamo-pituitarytesticular activities in adult rats: Possible an estrogenic mode of action", Reprod Biol Endocrinol, 16, pp.4~9 (2006)
- Kabbaj O, "Relationship of the hormone-sensitive lipasemediated modulation of cholesterol metabolism in individual compartments of the testis to serum pituitary hormone and testosterone concentrations in a seasonal breeder, the mink (Mustela vison)", Biol Reprod, 68, pp.722~734 (2003)
- Kim YJ, "Arsenic trioxide-induced apoptosis in TM4 Sertoli cells: the potential involvement of p21 expression and p53 phosphorylation", Toxicology, 285, pp.142~151 (2011)
- Kligerman AD, "Insights into the carcinogenic mode of action of arsenic", Toxicology and Applied Pharmacology, 222, pp.281~288 (2007)
- Kosentt MJ, "Poisoning and Drug Overdose", pp.87~89 (1994), Appleton and Lange
- Lin S, "Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes", Chemical Research in Toxicology, 14, pp.305~311 (2001)
- Liu J, "Liver is a target of arsenic carcinogenesis", Toxicol Sci, 105, pp.24~32 (2008)
- Mandal BK, "Arsenic round the world: a review", Talanta, 58, pp.201~235 (2002)
- Meeker JD, "Environmental exposure to metals and male reproductive hormones: Circulating testosterone is inversely associated with blood molybdenum", Fertil Steril, 93, pp.130~140 (2010)
- Milton AH, "Chronic arsenic exposure and adverse pregnancy outcomes in Bangladesh", Epidemiology, 16, pp.82~86 (2005)
- Miyazaki K, "The effects of gestational arsenic exposure and dietary selenium deficiency on selenium and selenoenzymes in maternal and fetal tissues in mice", Toxicology, 208, pp.357~365 (2005)
- Naiger RD, "Effect of sub acute lowlevel dietary sodium arsenite on dogs", Fundam Appl Toxicol, 13, pp.439~451 (1989)
- Naqvi SM, "Arsenic in the environment, Part II: Human Health and Ecosystem Effects", pp.55~91 (1994), Wiley-Interscience
- Nie JS, "Semen quality decreased by inorganic arsenic", J Environ Occup Med, 23, pp.189~190 (2006)
- NRC, "Arsenic in Drinking Water", pp.1~310 (1999), National Academy Press
- NRC, "Arsenic in Drinking Water: 2001 Update", pp.1~244 (2001), National Academy Press
- Pant N, "Male reproductive effect of arsenic in mice", Biometals, 14, pp.113~117 (2001)
- Pant N, "Male reproductive toxicity of sodium arsenite in mice", Hum Exp Toxicol, 23, pp.399~403 (2004)
- Pott WA, "Pharmacokinetics, metabolism, and carcinogenicity of arsenic", Rev Environ Contam Toxicol, 169, pp.165~214 (2001)
- Rahman A, "Association of arsenic exposure during pregnancy with fetal loss and infant death: a cohort study in Bangladesh", Am J Epidemiol, 165, pp.1389~1396 (2007)
- Rahman A, "Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh", Am J Epidemiol, 169, pp.304~312 (2009)
- Rodriguez VM, "Effects of sodium arsenite exposure on development and behavior in the rat", Neurotoxicol Teratol, 24, pp.743~750 (2002)
- Rogers EH, "The teratogenic potential of cacodylic acid in the rat and mouse", Drug Chem Toxicol, 4, pp.49~61 (1981)
- Rossman TG, "Mechanism of arsenic carcinogenesis: an integrated approach", Mutat Res, 533, pp.37~65 (2003)
- Russell LD, "The Sertoli Cell", pp.1~37 (1993), Cache River Press
- Sanghamitra S, "Arsenic induced toxicity on testicular tissue of mice", Indian J Physiol Pharmacol, 52, pp.84~90 (2008)
- Sarkar M, "Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats", Asian J Androl, 5, pp.27~31 (2003)
- Sarkar M, "Effect of sodium arsenite on spermatogenesis, plasma gonadotrophins and testosterone in rats", Asian J Androl, 1, pp.27~31 (2003)
- Schwerdtle T, "Induction of oxidative DNA damage by arsenite and its trivalent and pentavalent methylated metabolites in cultured human cells and isolated DNA", Carcinogenesis, 24, pp.967~974 (2003)
- Shen H, "Urinary metabolic biomarkers link oxidative stress indicators associated with general arsenic exposure to male infertility in a Han Chinese population", Environ Sci Technol, 47, pp.8843~8851 (2013)
- Smith AH, "Cancer risks from arsenic in drinking water", Environ Health Perspect, 97, pp.259~267 (1992)
- Smith AH, "Public health. Arsenic epidemiology and drinking water standards", Science, 296, pp.2145~2146 (2002)
- Smith TJ, "Airborne arsenic exposure and excretion of methylated arsenic compounds", Environ Health Perspect, 19, pp.89~93 (1977)
- Soignet SL, "Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide", N Engl J Med, 339, pp.1241~1348 (1998)
- Stump DG, "Comparative effects of single intraperitoneal or oral doses of sodium arsenate or arsenic trioxide during in utero development", Teratology, 60, pp.283~291 (1999)
- Styblo M, "Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols", Chem Res Toxicol, 10, pp.27~33 (1997)
- Tabocova S, "Developmental toxicity of inorganic arsenic in whole embryo: culture oxidation state, dose, time, and gestational age dependence", Toxicol Appl Pharmacol, 138, pp.298~307 (1996)
- Thomas DJ, "The cellular metabolism and systemic toxicity of arsenic", Toxicol Appl Pharmacol, 176, pp.127~144 (2001)
- Tseng CH, "A review on environmental factors regulating arsenic methylation in humans", Toxicology and Applied Pharmacology, 235, pp.338~350 (2009)
- Tseng CH, "Epidemiologic evidence of diabetogenic effect of arsenic", Toxicol Lett, 133, pp.69~76 (2002)
- Uckun FM, "Human sperm immobilizing activity of aminophenyl arsenic acid and its N-substituted quinazoline, pyrimidine, and purine derivatives: Protective effect of glutathione", Reprod Toxicol, 16, pp.57~64 (2002)
- Uslu R, "Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines", Clin Cancer Res, 6, pp.4957~4964 (2000)
- Vahter M, "Effects of arsenic on maternal and fetal health", Annu Rev Nutr, 29, pp.381~399 (2009)
- Vahter M, "In vivo reduction of arsenate in mice and rabbits", Environ Res, 32, pp.14~24 (1983)
- Vahter M, "Reduction and binding of arsenate in marmoset monkeys", Archives of Toxicology, 57, pp.119~124 (1985)
- Vreeburg JT, "Effects of corticosterone on the negative feedback action of testosterone, 5 alphadihydrotestosterone and estradiol in the adult male rat", J Steroid Biochem, 29, pp.93~98 (1988)
- Waalkes MP, "Induction of proliferate lesions of the uterus, testes, and liver in Swiss mice given repeated injections of sodium arsenate: possible estrogenic mode of action", Toxicol Appl Pharmacol, 166, pp.24~35 (2000)
- Waalkes MP, "Transplacental carcinogenicity of inorganic arsenic in the drinking water: induction of hepatic, ovarian, pulmonary, and adrenal tumors in mice", Toxicol Appl Pharmacol, 186, pp.7~17 (2003)
- Wasserman GA, "Environ Health Perspect", Environ Health Perspect, 112, pp.1329~1333 (2004)
- Watanabe C, "Effects of arsenic on younger generations", J Environ Sci Health, 38(Part A), pp.129~139 (2003)
- Environmental Health Criteria 18: Arsenic, "WHO", WHO, ~ (1981)
- WHO, "Air Quality Guidelines for Europe, WHO Regional Publications, European Series, 91", pp.1~288 (2000), WHO
- WHO, "Arsenic and Arsenic Compounds (Environmental Health Criteria 224)", WHO International Programme on Chemical Safety, ~ (2001)
- Yamauchi H, "Dynamic changes of inorganic and methylarsenic compounds in human urine after oral intake of arsenic trioxide", Indust Hygiene, 17, pp.79~83 (1979)
- Yang CY, "Arsenic in drinking water and adverse pregnancy outcome in an arseniasis-endemic area in northeastern Taiwan", Environ Res, 91, pp.29~34 (2003)
- Zhang TC, "Induction of apoptosis and inhibition of human gastric cancer MGC-803 cell growth by arsenic trioxide", Eur J Cancer, 35, pp.1258~1263 (1999)
