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Disturbance in Testosterone Production in Leydig Cells by Polycyclic Aromatic Hydrocarbons

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초록

Polycyclic aromatic hydrocarbons (PAHs), which are ubiquitous in the air, are present as volatile andparticulate pollutants that result from incomplete combustion. Most PAHs have toxic, mutagenic, and/or carcinogenicproperties. Among PAHs, benzo[a]pyrene (B[a]P) and dimethylbenz[a]anthracene (DMBA) are suspected endocrinedisruptors. The testis is an important target for PAHs, yet effects on steroidogenesis in Leydig cells are yet to be ascertained. Particularly, disruption of testosterone production by these chemicals can result in serious defects in male reproduction. Exposure to B[a]P reduced serum and intratesticular fluid testosterone levels in rats. Of note, the testosterone level reductionswere accompanied by decreased steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenaseisomerase (3b-HSD) expression in Leydig cells. B[a]P exposure can decrease epididymal sperm quality, possibly bydisturbing the testosterone level. StAR may be a key steroidogenic protein that is targeted by B[a]P or other PAHs

Abstract

Polycyclic aromatic hydrocarbons (PAHs), which are ubiquitous in the air, are present as volatile andparticulate pollutants that result from incomplete combustion. Most PAHs have toxic, mutagenic, and/or carcinogenicproperties. Among PAHs, benzo[a]pyrene (B[a]P) and dimethylbenz[a]anthracene (DMBA) are suspected endocrinedisruptors. The testis is an important target for PAHs, yet effects on steroidogenesis in Leydig cells are yet to be ascertained. Particularly, disruption of testosterone production by these chemicals can result in serious defects in male reproduction. Exposure to B[a]P reduced serum and intratesticular fluid testosterone levels in rats. Of note, the testosterone level reductionswere accompanied by decreased steroidogenic acute regulatory protein (StAR) and 3β-hydroxysteroid dehydrogenaseisomerase (3b-HSD) expression in Leydig cells. B[a]P exposure can decrease epididymal sperm quality, possibly bydisturbing the testosterone level. StAR may be a key steroidogenic protein that is targeted by B[a]P or other PAHs

참고문헌 (62)

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