Prognosis of Patients with Behavioral Variant Frontotemporal Dementia Who have Focal Versus Diffuse Frontal Atrophy
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Purpose Only a few studies have investigated the relationship between different subtypes and disease progression or prognosis in patients with behavioral variant frontotemporal dementia (bvFTD). Since a localized injury often produces more focal signs than a diffuse injury, we hypothesized that the clinical characteristics differ between patients with bvFTD who show diffuse frontal lobe atrophy (D-type) on axial magnetic resonance imaging (MRI) scans versus those with focal or circumscribed frontal lobe atrophy (F-type). Methods In total, 94 MRI scans (74 scans from bvFTD and 20 scans from age-matched normal controls) were classified into 35 D- and 39 F-type bvFTD cases based on an axial MRI visual rating scale. We compared baseline clinical characteristics, progression in motor and cognitive symptoms, and survival times between D- and F-types. Survival analyses were performed for 62 of the 74 patients. Results While D-type performed better on neuropsychological tests than F-type at baseline, D-type had higher baseline scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) Part III. Evaluations of motor progression showed that the disease duration with motor symptoms was shorter in D-type than F-type. Moreover, the survival time was shorter in D-type (6.9 years) than F-type (9.4 years). Cox regression analyses revealed that a high UPDRS Part III score at baseline contributed to an increased risk of mortality, regardless of the pattern of atrophy. Conclusions The prognosis is worse for D-type than for those with F-type. Shorter survival in D-type may be associated with the earlier appearance of motor symptoms.
Abstract
Background and Purpose Only a few studies have investigated the relationship between different subtypes and disease progression or prognosis in patients with behavioral variant frontotemporal dementia (bvFTD). Since a localized injury often produces more focal signs than a diffuse injury, we hypothesized that the clinical characteristics differ between patients with bvFTD who show diffuse frontal lobe atrophy (D-type) on axial magnetic resonance imaging (MRI) scans versus those with focal or circumscribed frontal lobe atrophy (F-type). Methods In total, 94 MRI scans (74 scans from bvFTD and 20 scans from age-matched normal controls) were classified into 35 D- and 39 F-type bvFTD cases based on an axial MRI visual rating scale. We compared baseline clinical characteristics, progression in motor and cognitive symptoms, and survival times between D- and F-types. Survival analyses were performed for 62 of the 74 patients. Results While D-type performed better on neuropsychological tests than F-type at baseline, D-type had higher baseline scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) Part III. Evaluations of motor progression showed that the disease duration with motor symptoms was shorter in D-type than F-type. Moreover, the survival time was shorter in D-type (6.9 years) than F-type (9.4 years). Cox regression analyses revealed that a high UPDRS Part III score at baseline contributed to an increased risk of mortality, regardless of the pattern of atrophy. Conclusions The prognosis is worse for D-type than for those with F-type. Shorter survival in D-type may be associated with the earlier appearance of motor symptoms.
참고문헌 (43)
- Josephs KA, "Neuropathological background of phenotypical variability in frontotemporal dementia", Acta Neuropathol, 122, pp.137~153 (2011)
- Snowden JS, "Distinct behavioural profiles in frontotemporal dementia and semantic dementia", J Neurol Neurosurg Psychiatry, 70, pp.323~332 (2001)
- Whitwell JL, "Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study", Brain, 132(Pt 11), pp.2932~2946 (2009)
- Kim EJ, "Patterns of MRI atrophy in tau positive and ubiquitin positive frontotemporal lobar degeneration", J Neurol Neurosurg Psychiatry, 78, pp.1375~1378 (2007)
- Borroni B, "Cerebrospinal fluid tau levels predict prognosis in non-inherited frontotemporal dementia", Neurodegener Dis, 13, pp.224~229 (2014)
- Borroni B, "Genetic background predicts poor prognosis in frontotemporal lobar degeneration", Neurodegener Dis, 8, pp.289~295 (2011)
- Josephs KA, "Predicting functional decline in behavioural variant frontotemporal dementia", Brain, 134(Pt 2), pp.432~448 (2011)
- Ranasinghe KG, "Distinct subtypes of behavioral variant frontotemporal dementia based on patterns of network degeneration", JAMA Neurol, 73, pp.1078~1088 (2016)
- Bergeron C, "Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders", pp.124~131 (2003), ISN Neuropath Press
- Boxer AL, "Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy", Arch Neurol, 63, pp.81~86 (2006)
- Rankin KP, "Behavioral variant frontotemporal dementia with corticobasal degeneration pathology: phenotypic comparison to bvFTD with Pick’s disease", J Mol Neurosci, 45, pp.594~608 (2011)
- Forman MS, "Frontotemporal dementia: clinicopathological correlations", Ann Neurol, 59, pp.952~962 (2006)
- Rascovsky K, "Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia", Brain, 134(Pt 9), pp.2456~2477 (2011)
- Kim EJ, "Clinical and neuropsychological characteristics of a nationwide hospitalbased registry of frontotemporal dementia patients in Korea: a CREDOS-FTD study", Dement Geriatr Cogn Dis Extra, 4, pp.242~251 (2014)
- 박희경, "Clinical Characteristics of a Nationwide Hospital-based Registry of Mild-to-Moderate Alzheimer’s Disease Patients in Korea: A CREDOS (Clinical Research Center for Dementia of South Korea) Study", Journal of Korean Medical Science, 26(9), pp.1219~1226 (2011), 대한의학회
- Han C, "An adaptation of the Korean Mini-Mental State Examination (K-MMSE) in elderly Koreans:demographic influence and population-based norms (the AGE study)", Arch Gerontol Geriatr, 47, pp.302~310 (2008)
- Knopman DS, "Development of methodology for conducting clinical trials in frontotemporal lobar degeneration", Brain, 131(Pt 11), pp.2957~2968 (2008)
- Reisberg B, "The Global Deterioration Scale for assessment of primary degenerative dementia", Am J Psychiatry, 139, pp.1136~1139 (1982)
- Hachinski VC, "Cerebral blood flow in dementia", Arch Neurol, 32, pp.632~637 (1975)
- Lesher EL, "Validation of the Geriatric Depression Scaleshort form among inpatients", J Clin Psychol, 50, pp.256~260 (1994)
- 안현정, "Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring Cognitive Impairments in Dementia Patients", Journal of Korean Medical Science, 25(7), pp.1071~1076 (2010), 대한의학회
- Sinoff G, "The Barthel Activities of Daily Living index: self-reporting versus actual performance in the old-old (> or = 75 years)", J Am Geriatr Soc, 45, pp.832~836 (1997)
- 구형모, "일상활동평가-복합(Seoul-Instrumental Activities of Daily Living ; S-IADL)의 신뢰도 및 타당도 연구", 신경정신의학, 43(2), pp.189~199 (2004), 대한신경정신의학회
- Kang SJ, "Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI)", J Geriatr Psychiatry Neurol, 17, pp.32~35 (2004)
- Kertesz A, "The Frontal Behavioral Inventory in the differential diagnosis of frontotemporal dementia", J Int Neuropsychol Soc, 6, pp.460~468 (2000)
- Goetz CG, "Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results", Mov Disord, 23, pp.2129~2170 (2008)
- Chow TW, "Visual rating versus volumetry to detect frontotemporal dementia", Dement Geriatr Cogn Disord, 31, pp.371~378 (2011)
- Victoroff J, "A method to improve interrater reliability of visual inspection of brain MRI scans in dementia", Neurology, 44, pp.2267~2276 (1994)
- Scheltens P, "Qualitative assessment of cerebral atrophy on MRI: inter- and intra-observer reproducibility in dementia and normal aging", Eur Neurol, 37, pp.95~99 (1997)
- Pan XD, "Clinic, neuropathology and molecular genetics of frontotemporal dementia: a mini-review", Transl Neurodegener, 2, pp.8~ (2013)
- Garcin B, "Determinants of survival in behavioral variant frontotemporal dementia", Neurology, 73, pp.1656~1661 (2009)
- Piguet O, "Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia", Neurology, 72, pp.732~737 (2009)
- Seelaar H, "Distinct genetic forms of frontotemporal dementia", Neurology, 71, pp.1220~1226 (2008)
- Padovani A, "Extrapyramidal symptoms in frontotemporal dementia: prevalence and clinical correlations", Neurosci Lett, 422, pp.39~42 (2007)
- Lagarde J, "Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study", PLoS One, 8, pp.e80353~ (2013)
- Kitagaki H, "Corticobasal degeneration:evaluation of cortical atrophy by means of hemispheric surface display generated with MR images", Radiology, 216, pp.31~38 (2000)
- Whitwell JL, "Imaging signatures of molecular pathology in behavioral variant frontotemporal dementia", J Mol Neurosci, 45, pp.372~378 (2011)
- Roberson ED, "Frontotemporal dementia progresses to death faster than Alzheimer disease", Neurology, 65, pp.719~725 (2005)
- Hodges JR, "Survival in frontotemporal dementia", Neurology, 61, pp.349~354 (2003)
- Kang SJ, "Survival in frontotemporal lobar degeneration in a Korean population", Alzheimer Dis Assoc Disord, 24, pp.339~342 (2010)
- Kansal K, "Survival in frontotemporal dementia phenotypes: a metaanalysis", Dement Geriatr Cogn Disord, 41, pp.109~122 (2016)
- Maust DT, "Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm", JAMA Psychiatry, 72, pp.438~445 (2015)
- Josephs KA, "Two distinct subtypes of right temporal variant frontotemporal dementia", Neurology, 73, pp.1443~1450 (2009)