18F-THK5351 PET Imaging in the Behavioral Variant of Frontotemporal Dementia
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Background and Purpose: Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and executive functions. The pathology of bvFTD is known to be tauopathy or TDP-43 equally. We analyzed the 18F-THK5351 positron emission tomography (PET) scans, which were recently developed tau PET, in patients with clinically-diagnosed bvFTD. Methods: Forty-eight participants, including participants with behavioral variant frontotemporal dementia (bvFTD, n =3), Alzheimer's disease (AD, n =21) and normal cognition (NC, n =24) who completed 3T magnetic resonance images, 18F-THK5351 PET scans, and detailed neuropsychological tests were included in the study. Voxel-wise statistical analysis and region of interest (ROI)-based analyses were performed to evaluate the retention of THK in bvFTD patients. Results: In the voxel-based and ROI-based analyses, patients with bvFTD showed greater THK retention in the prefrontal, medial frontal, orbitofrontal, anterior cingulate, insula, anterior inferior temporal and striatum regions compared to NC participants. Left-right asymmetry was noted in the bvFTD patients. A patient with extrapyramidal symptoms showed much greater THK retention in the brainstem. Conclusions: The distribution of THK retention in the bvFTD patients was mainly in the frontal, insula, anterior temporal, and striatum regions which are known to be the brain regions corresponding to the clinical symptoms of bvFTD. Our study suggests that 18F-THK5351 PET imaging could be a supportive tool for diagnosis of bvFTD.
Abstract
Background and Purpose: Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and executive functions. The pathology of bvFTD is known to be tauopathy or TDP-43 equally. We analyzed the 18F-THK5351 positron emission tomography (PET) scans, which were recently developed tau PET, in patients with clinically-diagnosed bvFTD. Methods: Forty-eight participants, including participants with behavioral variant frontotemporal dementia (bvFTD, n =3), Alzheimer's disease (AD, n =21) and normal cognition (NC, n =24) who completed 3T magnetic resonance images, 18F-THK5351 PET scans, and detailed neuropsychological tests were included in the study. Voxel-wise statistical analysis and region of interest (ROI)-based analyses were performed to evaluate the retention of THK in bvFTD patients. Results: In the voxel-based and ROI-based analyses, patients with bvFTD showed greater THK retention in the prefrontal, medial frontal, orbitofrontal, anterior cingulate, insula, anterior inferior temporal and striatum regions compared to NC participants. Left-right asymmetry was noted in the bvFTD patients. A patient with extrapyramidal symptoms showed much greater THK retention in the brainstem. Conclusions: The distribution of THK retention in the bvFTD patients was mainly in the frontal, insula, anterior temporal, and striatum regions which are known to be the brain regions corresponding to the clinical symptoms of bvFTD. Our study suggests that 18F-THK5351 PET imaging could be a supportive tool for diagnosis of bvFTD.
참고문헌 (32)
- Mackenzie IR, "Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update", Acta Neuropathol, 119, pp.1~4 (2010)
- Mackenzie IR, "Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions", Brain, 131, pp.1282~1293 (2008)
- Kertesz A, "The evolution and pathology of frontotemporal dementia", Brain, 128, pp.1996~2005 (2005)
- Rascovsky K, "Can clinical features predict tau pathology in patients with behavioral variant frontotemporal dementia (bvFTD)?", Neurology, 80, pp.P05.101~ (2013)
- Chare L, "New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications", J Neurol Neurosurg Psychiatry, 85, pp.865~870 (2014)
- Dickson DW, "Neuropathology of frontotemporal lobar degeneration-tau (FTLD-tau)", J Mol Neurosci, 45, pp.384~389 (2011)
- -T808, "J Alzheimers Dis", 2014, 171~184
- Harada R, "18F-THK5351: a novel PET radiotracer for imaging neurofibrillary pathology in Alzheimer disease", J Nucl Med, 57, pp.208~214 (2016)
- Cho H, "Predominant subcortical accumulation of 18F-flortaucipir binding in behavioral variant frontotemporal dementia", Neurobiol Aging, 66, pp.112~121 (2018)
- Lee MK, "1-methyl-2-undecyl-4(1H)-quinolone as an irreversible and selective inhibitor of type B monoamine oxidase", Chem Pharm Bull (Tokyo), 51, pp.409~411 (2003)
- Ng KP, "Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain", Alzheimers Res Ther, 9, pp.25~ (2017)
- Rascovsky K, "Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia", Brain, 134, pp.2456~2477 (2011)
- McKhann G, "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease", Neurology, 34, pp.939~944 (1984)
- Srikanth S, "Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular dementia and frontotemporal dementia", J Neurol Sci, 236, pp.43~48 (2005)
- Greve DN, "Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data", Neuroimage, 92, pp.225~236 (2014)
- Greve DN, "Different partial volume correction methods lead to different conclusions: an (18)F-FDG-PET study of aging", Neuroimage, 132, pp.334~343 (2016)
- Ossenkoppele R, "Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease", Brain, 139, pp.1551~1567 (2016)
- Okamura N, "Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET", Brain, 137, pp.1762~1771 (2014)
- THK-5351, "PLoS One", 2016, e0158460~
- Thurfjell L, "Automated quantification of 18F-flutemetamol PET activity for categorizing scans as negative or positive for brain amyloid: concordance with visual image reads", J Nucl Med, 55, pp.1623~1628 (2014)
- Amodio DM, "Meeting of minds: the medial frontal cortex and social cognition", Nat Rev Neurosci, 7, pp.268~277 (2006)
- Walton ME, "Functional specialization within medial frontal cortex of the anterior cingulate for evaluating effort-related decisions", J Neurosci, 23, pp.6475~6479 (2003)
- Happaney K, "Development of orbitofrontal function: current themes and future directions", Brain Cogn, 55, pp.1~10 (2004)
- Nobre AC, "Word recognition in the human inferior temporal lobe", Nature, 372, pp.260~263 (1994)
- Visser M, "Semantic processing in the anterior temporal lobes: a meta-analysis of the functional neuroimaging literature", J Cogn Neurosci, 22, pp.1083~1094 (2010)
- Burrell JR, "Cognition in corticobasal syndrome and progressive supranuclear palsy: a review", Mov Disord, 29, pp.684~693 (2014)
- Sidoryk-Wegrzynowicz M, "Role of astrocytes in brain function and disease", Toxicol Pathol, 39, pp.115~123 (2011)
- Broe M, "Astrocytic degeneration relates to the severity of disease in frontotemporal dementia", Brain, 127, pp.2214~2220 (2004)
- Harada R, "Correlations of 18F-THK5351 PET with postmortem burden of tau and astrogliosis in Alzheimer disease", J Nucl Med, 59, pp.671~674 (2018)
- Serrano-Pozo A, "Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease", Am J Pathol, 179, pp.1373~1384 (2011)
- Son HJ, "Differences in gray and white matter (18)F-THK5351 uptake between behavioral-variant frontotemporal dementia and other dementias", Eur J Nucl Med Mol Imaging, 46, pp.357~366 (2019)
- THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia, "Eur J Nucl Med Mol Imaging", 2018, 432~442