Seroepidemiology of Hepatitis Viruses and Hepatitis B Genotypes of Female Marriage Immigrants in Korea
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Purpose: The Korean society has moved rapidly toward becoming a multicultural society. This study aimed to estimate the seroprevalenceof hepatitis viruses and investigate hepatitis B virus (HBV) genotypic diversity in female marriage immigrants. Materials and Methods: Screening program was conducted at support centers for multicultural families in 21 administrative districtsin Korea between July 2011 and January 2017. A total of 963 female marriage immigrants were included in this study. Bloodsamples were tested for hepatitis viral markers and HBV genotype. Results: Subjects’ median age was 33 years (20–40 years), and they originated from nine countries including Vietnam (n=422,43.8%), China (n=311, 32.3%), the Philippines (n=85, 8.8%), Cambodia (n=58, 6.0%), and Japan (n=39, 4.0%). About 30% (n=288)of subjects required hepatitis A vaccination. HBsAg positive rate was 5.4% (n=52). Positive HBsAg results were the highest in subjectsfrom Southeast Asia (6.6%, n=38). Anti-HBs positive rate was 60.4% (n=582). About 34% (n=329) of subjects who were negativefor anti-HBs and HBsAg required HBV vaccinations. Genotypes B and C were found in 54.6% (n=12) and 45.4% (n=10) of the22 subjects with HBV, in whom genotypes were tested. Eight (0.8%) subjects were positive for anti-HCV. Positive anti-HCV resultswere the highest in subjects from Central Asia (7.9%, n=3). Conclusion: Testing for hepatitis viral marker (hepatitis A virus IgG and HBsAg/anti-HBs) is needed for female marriage immigrants. Especially, HBV genotype B is different from genotype C of Koreans. Therefore, interest and attention to vaccination programsfor female marriage immigrants are necessary for both clinicians and public health institutes.
Abstract
Purpose: The Korean society has moved rapidly toward becoming a multicultural society. This study aimed to estimate the seroprevalenceof hepatitis viruses and investigate hepatitis B virus (HBV) genotypic diversity in female marriage immigrants. Materials and Methods: Screening program was conducted at support centers for multicultural families in 21 administrative districtsin Korea between July 2011 and January 2017. A total of 963 female marriage immigrants were included in this study. Bloodsamples were tested for hepatitis viral markers and HBV genotype. Results: Subjects’ median age was 33 years (20–40 years), and they originated from nine countries including Vietnam (n=422,43.8%), China (n=311, 32.3%), the Philippines (n=85, 8.8%), Cambodia (n=58, 6.0%), and Japan (n=39, 4.0%). About 30% (n=288)of subjects required hepatitis A vaccination. HBsAg positive rate was 5.4% (n=52). Positive HBsAg results were the highest in subjectsfrom Southeast Asia (6.6%, n=38). Anti-HBs positive rate was 60.4% (n=582). About 34% (n=329) of subjects who were negativefor anti-HBs and HBsAg required HBV vaccinations. Genotypes B and C were found in 54.6% (n=12) and 45.4% (n=10) of the22 subjects with HBV, in whom genotypes were tested. Eight (0.8%) subjects were positive for anti-HCV. Positive anti-HCV resultswere the highest in subjects from Central Asia (7.9%, n=3). Conclusion: Testing for hepatitis viral marker (hepatitis A virus IgG and HBsAg/anti-HBs) is needed for female marriage immigrants. Especially, HBV genotype B is different from genotype C of Koreans. Therefore, interest and attention to vaccination programsfor female marriage immigrants are necessary for both clinicians and public health institutes.
참고문헌 (40)
- "Status of marriage migrant"[URL]
- Chae HB, "Current status of liver diseases in Korea: hepatitis B", Korean J Hepatol, 15(Suppl 6), pp.S13~S24 (2009)
- Amarsanaa Jazag, "Status Quo of Chronic Liver Diseases, Including Hepatocellular Carcinoma, in Mongolia", The Korean Journal of Internal Medicine, 27(2), pp.121~127 (2012), 대한내과학회[DOI]
- Merican I, "Chronic hepatitis B virus infection in Asian countries", J Gastroenterol Hepatol, 15, pp.1356~1361 (2000)
- Nguyen VT, "Hepatitis B infection in Vietnam : current issues and future challenges", Asia Pac J Public Health, 24, pp.361~373 (2012)
- Sievert W, "A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt", Liver Int, 31(Suppl 2), pp.61~80 (2011)
- 정성준, "Changes in the seroprevalence of IgG anti-hepatitis A virus between 2001 and 2013: experience at a single center in Korea", Clinical and Molecular Hepatology, 20(2), pp.162~167 (2014), 대한간학회[DOI]
- Jeong SH, "Hepatitis A : clinical manifestations and management", Intervirology, 53, pp.15~19 (2010)
- Lee HW, "Clinical factors and viral load influencing severity of acute hepatitis A", PLoS One, 10, pp.e0130728~ (2015)
- 조금준, "Hepatitis A virus infection during pregnancy in Korea: Hepatitis A infection on pregnant women", Obstetrics & Gynecology Science, 56(06), pp.368~374 (2013), 대한산부인과학회[DOI]
- Rossi C, "Seroprevalence of chronic hepatitis B virus infection and prior immunity in immigrants and refugees: a systematic review and meta-analysis", PLoS One, 7, pp.e44611~ (2012)
- Tong MJ, "Hepatitis B virus infection in Asian Americans", Gastroenterol Clin North Am, 23, pp.523~536 (1994)
- Phung TB, "Genotype X", C recombinant (putative genotype I) of hepatitis B virus is rare in Hanoi, Vietnam--genotypes B4 and C1 predominate, 2010, pp.82, 1327~1333
- Tatematsu K, "A genetic variant of hepatitis B virus divergent from known human and ape genotypes isolated from a Japanese patient and provisionally assigned to new genotype J", J Virol, 83, pp.10538~10547 (2009)
- Jia-Horng Kao, "Molecular Epidemiology of Hepatitis B Virus", The Korean Journal of Internal Medicine, 26(3), pp.255~261 (2011), 대한내과학회
- Lin CL, "The clinical implications of hepatitis B virus genotype : recent advances", J Gastroenterol Hepatol, 26(Suppl 1), pp.123~130 (2011)
- Lee SH, "Distribution of HBV genotypes in patients with chronic HBV infection in Korea", Korean J Hepatol, 7, pp.373~380 (2001)
- Choi MS, "Clinical significance of pre-S mutations in patients with genotype C hepatitis B virus infection", J Viral Hepat, 14, pp.161~168 (2007)
- Gower E, "Global epidemiology and genotype distribution of the hepatitis C virus infection", J Hepatol, 61(1 Suppl), pp.S45~S57 (2014)
- Kim DY, "A nationwide seroepidemiology of hepatitis C virus infection in South Korea", Liver Int, 33, pp.586~594 (2013)
- Yoon EL, "Current status and strategies for the control of viral hepatitis A in Korea", Clin Mol Hepatol, 23, pp.196~204 (2017)
- Lee D, "Hepatitis a in Korea : epidemiological shift and call for vaccine strategy", Intervirology, 51, pp.70~74 (2008)
- 이동훈, "A nationwide seroprevalence of total antibody to hepatitis A virus from 2005 to 2009: age and area-adjusted prevalence rates", Clinical and Molecular Hepatology, 17(1), pp.44~50 (2011), 대한간학회
- Korea Centers for Disease Control, "Infectious diseases surveillance yearbook, 2015" (2016), Korea Centers for Disease Control and Prevention
- "Recommended immunization schedule for adults in Korea, by the Korean Society of Infectious Diseases, 2012", Clin Exp Vaccine Res, 3, pp.110~112 (2014)
- Jacobsen KH, "Hepatitis A virus seroprevalence by age and world region, 1990 and 2005", Vaccine, 28, pp.6653~6657 (2010)
- Yun H, "Seroepidemiology of hepatitis a infection in northeastern china, Korea, and Japan", Osong Public Health Res Perspect, 3, pp.31~35 (2012)
- Poovorawan K, "Hepatitis B vaccination for international travelers to Asia", Trop Dis Travel Med Vaccines, 2, pp.14~ (2016)
- Avazova D, "Hepatitis B virus transmission pattern and vaccination efficiency in Uzbekistan", J Med Virol, 80, pp.217~224 (2008)
- Davaalkham D, "Impact of the universal hepatitis B immunization program in Mongolia : achievements and challenges", J Epidemiol, 17, pp.6975~ (2007)
- Nurgalieva ZZ, "Epidemiology and transmission of hepatitis B and C viruses in Kazakhstan", World J Gastroenterol, 13, pp.1204~1207 (2007)
- Schweitzer A, "Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013", Lancet, 386, pp.1546~1555 (2015)
- Elgouhari HM, "Hepatitis B virus infection: understanding its epidemiology, course, and diagnosis", Cleve Clin J Med, 75, pp.881~889 (2008)
- Cho EJ, "Current status and strategies for hepatitis B control in Korea", Clin Mol Hepatol, 23, pp.205~211 (2017)
- 김혜경, "Health Status and Associated Health Risks among Female Marriage Immigrants in Korea", 보건교육건강증진학회지, 27(5), pp.79~89 (2010), 한국보건교육건강증진학회
- Kao JH, "Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma : epidemiologic and molecular biological aspects", Adv Cancer Res, 108, pp.21~72 (2010)
- McMahon BJ, "The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis B", Hepatol Int, 3, pp.334~342 (2009)
- Sunbul M, "Hepatitis B virus genotypes : global distribution and clinical importance", World J Gastroenterol, 20, pp.5427~5434 (2014)
- Petruzziello A, "Global epidemiology of hepatitis C virus infection : an up-date of the distribution and circulation of hepatitis C virus genotypes", World J Gastroenterol, 22, pp.7824~7840 (2016)
- Korean Women’s Development Institute, "The survey of current state of multicultural family in Korea" (2015), Ministiry of Gender Equality and Family