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Reverse Transcription-Polymerase Chain Reaction-Restriction Fragment Length Polymorphism로 진단된 서울바이러스(Seoul virus)에 의한 신증후출혈열 1예

A Case of Hemorrhagic Fever with Renal Syndrome by Seoul Virus Confirmed by Reverse Transcription-PolymeraseChain Reaction-Restriction Fragment Length Polymorphism

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참고문헌

주제분류병리학

초록

신증후출혈열은 한타바이러스 속에 의해 감염되는 급성 열성 질환으로, 발진 발열 등의 비슷한 초기증상으로 인하여 정확한 진단이 어려운 경우가 있다. 우리나라의 신증후출혈열은 한탄바이러스및 서울바이러스가 원인이며 서울바이러스에 의한 감염의 증상이더 경하다. 저자들은 열감, 근육통, 얼굴 부종 및 설사 증상으로내원한 4세 여자환자에서 한탄바이러스에 대한 항체가 간접면역형광법으로 양성이었으며, 바이러스 S 분절에 대한 역전사핵산증폭-제한효소 절편검사로써 서울바이러스를 감별 진단할 수 있었던예를 경험하였다. 이에 서울바이러스에 의한 신증후출혈열의 예를임상증상에 대한 문헌고찰과 함께 보고하는 바이다.

Abstract

Members of the genus Hantavirus are the etiologic agents of hemorrhagic fever with renal syndrome (HFRS), the diagnosis of which is somewhat difficult because several diseases share similar early clinical presentations such as fever and petechia. In Korea, Hantaan virus and Seoul virus are the causative organisms of HFRS, and the infection caused by Seoul virus is milder than that caused by Hantaan virus. We report a 44-year-old woman, who visited our hospital due to general weakness, fever, myalgia, facial edema and diarrhea. She was diagnosed with HFRS caused by Seoul virus. The antibody against Hantaan virus was positive by an indirect immunofluorescent test and the discrimination between Hantaan and Seoul viruses was done by RT-PCR-RFLP (reverse transcriptionpolymerase chain reaction-restriction fragment length polymorphism) against viral S segment.

참고문헌 (22)

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