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신증후군 출혈열

Hemorrhagic Fever with Renal Syndrome

김효열
대한감염학회 (The Korean Society Of Infectious Diseases)|2009.12|Infection and Chemotherapy|제41권 제6호|pp. 323-332

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참고문헌

키워드

Hantaan virusHemorrhagic fever with renal syndromeHantavirus
주제분류내과학

초록

Hemorrhagic fever with renal syndrome (HFRS) is an acute febrile illness caused by Eurasian hantaviruses and characterized by renal insufficiency, hemorrhage, thrombocytopenia, and shock. Each hantavirus is primarily associated with a single rodent host species or genus, and is transmitted to human via aerosols of rodent excreta. During the last decades, clinical features of HFRS in Korea have changed with mild degree of hypotension and very low prevalence of oliguria. Treatment of HFRS is mainly supportive. Recently, however, treatment of HFRS patients with ribavirin in China and Korea, within 7 days after the onset of fever, resulted in a reduced mortality as well as shortened course of illness. Although a commercial inactivated Hantaan virus vaccine has been on the market in Korea for more than 15 years, the effect of vaccination is not clear. Further efforts are necessary to develop safer and more effective hantavirus vaccines.

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is an acute febrile illness caused by Eurasian hantaviruses and characterized by renal insufficiency, hemorrhage, thrombocytopenia, and shock. Each hantavirus is primarily associated with a single rodent host species or genus, and is transmitted to human via aerosols of rodent excreta. During the last decades, clinical features of HFRS in Korea have changed with mild degree of hypotension and very low prevalence of oliguria. Treatment of HFRS is mainly supportive. Recently, however, treatment of HFRS patients with ribavirin in China and Korea, within 7 days after the onset of fever, resulted in a reduced mortality as well as shortened course of illness. Although a commercial inactivated Hantaan virus vaccine has been on the market in Korea for more than 15 years, the effect of vaccination is not clear. Further efforts are necessary to develop safer and more effective hantavirus vaccines.

참고문헌 (52)

  1. Krger DH, "Hantavirus infections and their prevention", Microbes Infect, 3, pp.1129~1144 (2001)
  2. Lee JS, "Clinical features of hemorrhagic fever with renal syndrome in Korea", Kidney Int Suppl, 35, pp.S88~93 (1991)
  3. Muranyi W, "van der Woude FJ. Hantavirus infection", J Am Soc Nephrol, 16, pp.3669~3679 (2005)
  4. 이남석, "최근 5년간 신증후군 출혈열의 임상양상: 백신 도입 이전과 비교", 대한내과학회지, 76(4), pp.459~466 (2009), 대한내과학회
  5. 김호중, "Diagnostic challenge of hemorrhagic fever with renal syndrome (HFRS) on admission before its serological confirmation", Kidney Research and Clinical Practice, 23(1), pp.82~91 (2004), 대한신장학회
  6. Johnson KM, "Hantaviruses: history and overview", Curr Top Microbiol Immunol, 256, pp.1~14 (2001)
  7. Lee JK, "Hemorrhagic fever with renal syndrome: Historical aspects", Korean J Med Hist, 13, pp.37~61 (2004)
  8. Smadel JE, "Epidemic hemorrhagic fever", Am J Public Health Nations Health, 43, pp.1327~1330 (1953)
  9. Lee HW, "Isolation of the etiologic agent of Korean Hemorrhagic fever", J Infect Dis, 137, pp.298~308 (1978)
  10. Gajdusek DC, "Virus hemorrhagic fevers. Special reference to hemorrhagic fever with renal syndrome (epidemic hemorrhagic fever)", J Pediatr, 60, pp.841~857 (1962)
  11. World Health Organization, "Haemorrhagic fever with renal syndrome: memorandum from a WHO meeting", Bull World Health Organ, 61, pp.269~275 (1983)
  12. Nichol ST, "Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness", Science, 262, pp.914~917 (1993)
  13. Vapalahti O, "Hantavirus infections in Europe", Lancet Infect Dis, 3, pp.653~661 (2003)
  14. Lee HW, "fever with renal syndrome in Korea", Rev Infect Dis 11 Suppl4, pp.S864~876 (1989)
  15. Bruno P, "The protean manifestations of hemorrhagic fever with renal syndrome. A retrospective review of 26 cases from Korea", Ann Intern Med, 113, pp.385~391 (1990)
  16. Kim YK, "Clinical and laboratory predictors of oliguric renal failure in haemorrhagic fever with renal syndrome caused by Hantaan virus", J Infect, 54, pp.381~386 (2007)
  17. Kim YS, "Hemorrhagic fever with renal syndrome caused by the Seoul virus", Nephron, 71, pp.419~427 (1995)
  18. Lee HW, "Epidemiology and epizoology in Manual of Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome", pp.39~ (1999), Institute for Life Sciences
  19. Joon Young Song, "Epidemiology of Hemorrhagic Fever with Renal Syndrome in Endemic Area of the Republic of Korea, 1995-1998", Journal of Korean Medical Science, 21(4), pp.614~620 (2006), 대한의학회
  20. Lednicky JA, "Hantaviruses", Arch Pathol Lab Med, 127, pp.30~35 (2003)
  21. Zeier M, "New ecological aspects of hantavirus infection: a change of a paradigm and a challenge of prevention-a review", Virus Genes, 30, pp.157~180 (2005)
  22. Maes P, "Hantaviruses: immunology, treatment, and prevention", Viral Immunol, 17, pp.481~497 (2004)
  23. Baek-Nam Kim, "Hemorrhagic Fever with Renal Syndrome Complicated with Pregnancy: A Case Report", The Korean Journal of Internal Medicine, 21(2), pp.150~153 (2006), 대한내과학회
  24. Baek LJ, "Soochong virus: an antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea", J Med Virol, 78, pp.290~297 (2006)
  25. Song KJ, "Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea", J Gen Virol 88, 11, pp.3121~3129 (2007)
  26. Song JW, "Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura)", J Virol, 83, pp.6184~6191 (2009)
  27. Nemirov K, "Phylogenetic evidence for host switching in the evolution of hantaviruses carried by Apodemus mi", Virus Res, 90, pp.207~215 (2002)
  28. Cosgriff TM, "Mechanisms of disease in Hantavirus infection: pathophysiology of hemorrhagic fever with renal syndrome", Rev Infect Dis, 13, pp.97~107 (1991)
  29. Van Epps HL, "Human memory cytotoxic T-lymphocyte (CTL) responses to Hantaan virus infection: identification of virus- specific and cross-reactive CD8(+) CTL epitopes on nucleocapsid protein", J Virol, 73, pp.5301~5308 (1999)
  30. Linderholm M, "Elevated plasma levels of tumor necrosis factor (TNF)-alpha, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome", J Infect Dis, 173, pp.38~43 (1996)
  31. Groeneveld PH, "Increased production of nitric oxide in patients infected with the European variant of hantavirus", Scand J Infect Dis, 27, pp.453~456 (1995)
  32. Papadimitriou M, "Hantavirus nephropathy", Kidney Int, 48, pp.887~902 (1995)
  33. Lee EJ, "Clinical significance of renal biopsy in hemorrhagic fever with renal syndrome", Korean J Med, 40, pp.642~652 (1991)
  34. Mkel S, "Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha (-308) G", A polymorphism, 2002, pp.186, 843~846
  35. Mustonen J, "Association of HLA B27 with benign clinical course of nephropathia epidemica caused by Puumala hantavirus", Scand J Immunol, 47, pp.277~279 (1998)
  36. YoungOkKim, "Serum Albumin Level Correlates with Disease Severity in Patients with Hemorrhagic Fever with Renal Syndrome", Journal of Korean Medical Science, 18(5), pp.696~700 (2003), 대한의학회
  37. Baek-Nam Kim, "Hemorrhagic Fever with Renal Syndrome Complicated with Pregnancy: A Case Report", The Korean Journal of Internal Medicine, 21(2), pp.150~153 (2006), 대한내과학회
  38. Hujakka H, "Diagnostic rapid tests for acute hantavirus infections: specific tests for Hantaan, Dobrava and Puumala viruses versus a hantavirus combination test", J Virol Methods, 108, pp.117~122 (2003)
  39. Woo HJ, "Diagnosis of acute Hantaan virus infection by IgG avidity assay", Korean J Med, 56, pp.629~635 (1999)
  40. H J, "Real-time rt-PCR of hantaan virus RNA used for the detection of virus response to antiviral drugs", Acta Virol, 52, pp.67~70 (2008)
  41. Huggins JW, "Prospective, double-blind, concurrent, placebo-controlled clinical trial of intravenous ribavirin therapy of hemorrhagic fever with renal syndrome", J Infect Dis, 164, pp.1119~1127 (1991)
  42. Rusnak JM, "Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea", Antiviral Res, 81, pp.68~76 (2009)
  43. Lee CH, "Persistence of antibodies after immunization with the inactivated vaccine against hemorrhagic fever with renal syndrome in humans", J Korean Soc Virol, 22, pp.239~243 (1992)
  44. Sohn YM, "Primary humoral immune responses to formalin inactivated hemorrhagic fever with renal syndrome vaccine (Hantavax®): consideration of active immunization in South Korea", Yonsei Med J, 42, pp.278~284 (2001)
  45. The Korean Society of Infectious Diseases, "Vaccination for adults" (2007), Koonja Publishing Co.
  46. Park K, "Protective effectiveness of hantavirus vaccine", Emerg Infect Dis, 10, pp.2218~2220 (2004)
  47. Woo YD, "An immunoserological study of vaccine against haemorrhagic fever with renal syndrome", J Korean Soc Virol, 30, pp.11~18 (2000)
  48. Cho HW, "Antibody responses in humans to an inactivated hantavirus vaccine (Hantavax)", Vaccine, 17, pp.2569~2575 (1999)
  49. Chu YK, "Immune response and antibody persistence against Hantaan virus of vaccinees with HantavaxTM", Korean J Infect Dis, 30, pp.317~324 (1998)
  50. Chu YK, "A field efficacy trial of inactivated Hantaan virus vaccine (HantavaxTM) against hemorrhagic Fever with Renal Syndrome (HFRS) in the Endemic Areas of Yugoslavia from 1996 to 1998", J Korean Soc Virol, 29, pp.55~64 (1999)
  51. Schmaljohn C, "Vaccines for hantaviruses", Vaccine 27 Suppl4, pp.D61~64 (2009)
  52. McClain DJ, "Clinical evaluation of a vaccinia- vectored Hantaan virus vaccine", J Med Virol, 60, pp.77~85 (2000)

관련 논문AI추천

Hemorrhagic Fever with Renal Syndrome: Literature Review, Epidemiology, Clinical Picture and Pathogenesis김동민, Tariq Misbah대한감염학회 · Infection and Chemotherapy2022 · 제54권 제1호Hemorrhagic Fever with Renal Syndrome노지윤, 송진원, 정재훈대한감염학회 · Infection and Chemotherapy2019 · 제51권 제4호신증후출혈열정종학영남대학교 의과대학 · Journal of Yeungnam Medical Science1998 · 제15권 제1호제주도에서 발생한 신증후군 출혈열 1예김영리, 김진석, 유정래, 이근화, 임채문, 허상택대한감염학회 · Infection and Chemotherapy2012 · 제44권 제6호신증후출혈열에서 급성 핍뇨성 신부전의 임상양상 및 예측인자김영근, 김준명, 김창수, 이상철, 최창민, 허상택대한내과학회 · 대한내과학회지2006 · 제70권 제2호신증후 출혈열의 질병사적 고찰이재광, 황상익대한의사학회 · 의사학2004 · 제13권 제1호

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