Usefulness of cyclic thermal therapy and red blood cell scintigraphy in patients with chemotherapy-induced peripheral neuropathy
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer– Quality of Life Questionnaire–Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient’s hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.
Abstract
Background: Pharmacological and non-pharmacological therapies have been used to treat patients with chemotherapy-induced peripheral neuropathy (CIPN). However, the effect of therapies in cancer patients has yet to be investigated comprehensively. We hypothesized that cyclic thermal therapy would improve blood flow and microcirculation and improve the symptoms driven by CIPN. Methods: The criteria of assessment were blood volume in region of interest (ROI) in the images, and European Organization for Research and Treatment of Cancer– Quality of Life Questionnaire–Chemotherapy-Induced Peripheral Neuropathy 20 questionnaire scores. The blood volume was quantified by using red blood cell (RBC) scintigraphy. All patients were treated 10 times during 10 days. The thermal stimulations, between 15° and 41°, were repeatedly delivered to the patient’s hands. Results: The total score of the questionnaires, the score of questions related to the upper limbs, the score of questions closely related to the upper limbs, and the score excluding the upper limbs questions was decreased. The blood volume was decreased, and the variance of blood volume was decreased. During cooling stimulation, the blood volume was decreased, and its variance was decreased. During warming stimulation, the blood volume was decreased, and its variance was decreased. Conclusions: We suggest that cyclic thermal therapy is useful to alleviate CIPN symptoms by blood circulation improvement. RBC scintigraphy can provide the quantitative information on blood volume under certain conditions such as stress, as well as rest, in peripheral tissue.
참고문헌 (27)
- Windebank AJ, "Chemotherapy-induced neuropathy", J Peripher Nerv Syst, 13, pp.27~46 (2008)
- Armstrong T, "Chemotherapyinduced peripheral neuropathy", Oncol Nurs Forum, 32, pp.305~311 (2005)
- Kumar SP, "Chemotherapy-induced or chemotherapy-associated? Does physical therapy play a role in prevention and", or management of peripheral neurotoxicity and neuropathy?, 2013, pp.19, 77~78
- Wolf S, "Chemotherapy-induced peripheral neuropathy : prevention and treatment strategies", Eur J Cancer, 44, pp.1507~1515 (2008)
- 우인숙, "항암제에 의한 말초 신경병증의 최신 지견", 대한내과학회지, 88(1), pp.35~37 (2015), 대한내과학회[DOI]
- Barton DL, "A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy : NCCTG trial N06CA", Support Care Cancer, 19, pp.833~841 (2011)
- Wickham R, "Chemotherapy-induced peripheral neuropathy : a review and implications for oncology nursing practice", Clin J Oncol Nurs, 11, pp.361~376 (2007)
- Sutterfield SL, "Lower cutaneous microvascular reactivity in adult cancer patients receiving chemotherapy", J Appl Physiol (1985), 125, pp.1141~1149 (2018)
- Akasaki Y, "Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia", Circ J, 70, pp.463~470 (2006)
- Tepperman PS, "The therapeutic use of local heat and cold", Can Fam Physician, 32, pp.1110~1114 (1986)
- Johnson JM, "Cutaneous vasodilator and vasoconstrictor mechanisms in temperature regulation", Compr Physiol, 4, pp.33~89 (2014)
- Maeda H, "Microvascular circulation at cool, normal and warm temperatures in rat leg muscles examined by histochemistry using Lycopersicon esculentum lectin", Acta Histochem, 116, pp.1096~1103 (2014)
- Salmi AM, "Preoperative cooling and warming of the donor site increase survival of skin flaps by the mechanism of ischaemic preconditioning : an experimental study in rats", Scand J Plast Reconstr Surg Hand Surg, 33, pp.163~167 (1999)
- Roque FR, "Exercise training and cardiometabolic diseases : focus on the vascular system", Curr Hypertens Rep, 15, pp.204~214 (2013)
- Bang SH, "Evaluation of finger blood flow with Tc-99m MDP(methylene diphosphonate)", Korean J Intern Med, 7, pp.94~101 (1992)
- Kunnen JJ, "Effects of intra-arterial ketanserin in Raynaud’s phenomenon assessed by 99MTc-pertechnetate scintigraphy", Eur J Clin Pharmacol, 34, pp.267~271 (1988)
- Sarikaya A, "Assessment of digital ischaemia and evaluation of response to therapy by 99mTc sestamibi limb scintigraphy after local cooling of the hands in patients with vasospastic Raynaud’s syndrome", Nucl Med Commun, 25, pp.207~211 (2004)
- Kaminaga T, "Improvement in cold-induced Raynaud’s syndrome with administration of ticlopidine hydrochloride detected by Tc-99m DTPA human serum albumin scintigraphy", Clin Nucl Med, 27, pp.131~132 (2002)
- Garai I, "Is MIBI the best choice for the evaluation of hand perfusion during cold test provocation?", Nucl Med Commun, 26, pp.269~270 (2005)
- Habash RW, "Thermal therapy, part 1 : an introduction to thermal therapy", Crit Rev Biomed Eng, 34, pp.459~489 (2006)
- Postma TJ, "The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy : the QLQ-CIPN20", Eur J Cancer, 41, pp.1135~1139 (2005)
- Wolf SL, "The relationship between numbness, tingling, and shooting", burning pain in patients with chemotherapy-induced peripheral neuropathy(CIPN)as measured by the EORTC QLQCIPN20instrument, N06CA, 2012, pp.20, 625~632
- Hing WA, "Contrast therapy--a systematic review", Phys Ther Sport, 9, pp.148~161 (2008)
- Mols F, "Reference data of the European Organisation for Research and Treatment of Cancer(EORTC)QLQ-CIPN20 Questionnaire in the general Dutch population", Eur J Cancer, 69, pp.28~38 (2016)
- Piao CH, "Effects of thermal therapy combined with blue light-emitting diode irradiation on trimellitic anhydride-induced acute contact hypersensitivity mouse model", J Dermatolog Treat (2020)[DOI]
- Diskin CJ, "Towards an understanding of oedema", BMJ, 318, pp.1610~1613 (1999)
- Wang SJ, "Peripheral vasoreactivity in acute ischemic stroke with hemiplegia", Sci Rep, 11, pp.8531~ (2021)