Thyroid Stimulating Hormone, Cognitive Impairment and Depression in an Older Korean Population
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
ObjectiveaaAssociations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after controlling for potential confounding factors. MethodsaaThe sample consisted of 495 community residents aged 65 or over in whom serum TSH had been assayed. Cognitive impairment was defined using the Community Screening Interview for Dementia, and depression was diagnosed using the Geriatric Mental State schedule. Age, gender, education, smoking history, physical activity, blood pressure, diabetes, and serum total cholesterol and albumin were included as covariates. ResultsaaThere was a significant association between lower (hyperthyroid) serum TSH levels (<0.5 mIU/L) and cognitive impairment after adjustment [odds ratio 7.12 (95% confidence interval 1.35-37.5)]. However, no association was found between TSH levels and depression. ConclusionaaBased on TSH levels, hyperthyroidism but not hypothyroidism was associated with cognitive impairment in this sample, and we found no evidence for an association of either with depression.
Abstract
ObjectiveaaAssociations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after controlling for potential confounding factors. MethodsaaThe sample consisted of 495 community residents aged 65 or over in whom serum TSH had been assayed. Cognitive impairment was defined using the Community Screening Interview for Dementia, and depression was diagnosed using the Geriatric Mental State schedule. Age, gender, education, smoking history, physical activity, blood pressure, diabetes, and serum total cholesterol and albumin were included as covariates. ResultsaaThere was a significant association between lower (hyperthyroid) serum TSH levels (<0.5 mIU/L) and cognitive impairment after adjustment [odds ratio 7.12 (95% confidence interval 1.35-37.5)]. However, no association was found between TSH levels and depression. ConclusionaaBased on TSH levels, hyperthyroidism but not hypothyroidism was associated with cognitive impairment in this sample, and we found no evidence for an association of either with depression.
참고문헌 (32)
- Canaris GJ, "The Colorado thyroid disease prevalence study", Arch Intern Med, 160, pp.526~534 (2000)
- Surks MI, "Subclinical thyroid disease: scientific review and guidelines for diagnosis and management", JAMA, 291, pp.228~238 (2004)
- Biondi B, "The clinical significance of subclinical thyroid dysfunction", Endocr Rev, 29, pp.76~131 (2008)
- Rodondi N, "Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death", Arch Intern Med, 165, pp.2460~2466 (2005)
- Ceresini G, "Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study", J Am Geriatr Soc, 57, pp.89~93 (2009)
- Kalmijn S, "Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study", Clin Endocrinol, 53, pp.733~737 (2000)
- Gussekloo J, "Thyroid status, disability and cognitive function, and survival in old age", JAMA, 292, pp.2591~2599 (2004)
- Roberts LM, "Is subclinical thyroid dysfunction in the elderly associated with depression or cognitive dysfunction?", Ann Intern Med, 145, pp.573~581 (2006)
- Samuels MH, "Health status, mood, and cognition in experimentally induced subclinical hypothyroidism", J Clin Endocrinol Metab, 92, pp.2545~2551 (2007)
- Zhu DF, "fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism", Brain, 129, pp.2923~2930 (2006)
- Tan ZS, "Thyroid function and the risk of Alzheimer disease: the Framingham Study", Arch Intern Med, 168, pp.1514~1520 (2008)
- Chueire VB, "Subclinical hypothyroidism increases the risk for depression in the elderly", Arch Gerontol Geriatr, 44, pp.21~28 (2007)
- Thomsen AF, "Increased risk of developing affective disorder in patients with hypothyroidism: a register-based study", Thyroid, 15, pp.700~707 (2005)
- Engum A, "An association between depression, anxiety and thyroid function--a clinical fact or an artefact?", Acta Psychiatr Scand, 106, pp.27~34 (2002)
- Fraser SA, "Low yield of thyroid-stimulating hormone testing in elderly patients with depression", Gen Hosp Psychiatry, 26, pp.302~309 (2004)
- Prince M, "Dementia diagnosis in developing countries: a cross-cultural validation study", Lancet, 361, pp.909~917 (2003)
- Kim JM, "Vascular disease", risk and late-life Depression in a Korean community population, 2004, pp.185, 102~107
- Kim JM, "Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders", Biol Psychiatry, 62, pp.423~428 (2007)
- Hall KS, "The development of a dementia screening interview in two distinct languages", Int J Meth Psychiatr Res, 3, pp.1~28 (1993)
- 김재민, "한국어판 지역사회 치매선별 검사도구(CSID-K)의 개발", 신경정신의학, 43(4), pp.445~451 (2004), 대한신경정신의학회
- Copeland JR, "A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT", Psychol Med, 16, pp.89~99 (1986)
- Kim JM, "Diagnosing dementia in a developing nation: an evaluation of the GMS-AGECAT algorithm in an older Korean population", Int J Geriatr Psychiatry, 18, pp.331~336 (2003)
- Latasa MJ, "Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells", Endocrinology, 139, pp.2692~2698 (1998)
- de Jong FJ, "Thyroid function, the risk of dementia and neuropathologic changes: the Honolulu-Asia aging study", Neurobiol Aging, 30, pp.600~606 (2009)
- de Jong FJ, "Thyroid hormones, dementia, and atrophy of the medial temporal lobe", J Clin Endocrinol Metab, 91, pp.2569~2573 (2006)
- Scobbo RR, "Serum TSH variability in normal individuals: the influence of time of sample collection", W V Med J, 100, pp.138~142 (2004)
- Musselman DL, "Depression and endocrine disorders: focus on the thyroid and adrenal system", Br J Psychiatry Suppl, 30, pp.123~128 (1996)
- Haggerty JJ Jr, "Subclinical hypothyroidism: a modifiable risk factor for depression?", Am J Psychiatry, 150, pp.508~510 (1993)
- Copeland JRM, "The epidemiology of dementia: GMS-AGECAT studies of prevalence and incidence, including studies in progress", Eur Arch Psychiatry Clin Neurosci, 240, pp.212~217 (1991)
- Utiger RD, "Cigarette smoking and the thyroid", N Engl J Med, 333, pp.1001~1002 (1995)
- Holm IA, "Smoking and other lifestyle factors and the risk of Graves’ hyperthyroidism", Arch Intern Med, 165, pp.1606~1611 (2005)
- Kim JM, "Lifetime urban", rural residence, social support and late-life depression in Korea, 2004, pp.19, 843~851