본문 바로가기
KERD
논문KCI 등재

Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Causing Invasive Pneumococcal Disease in Korea Between 2017 and 2019 After Introduction of the 13-Valent Pneumococcal Conjugate Vaccine

1

조회

0

다운로드

3

인용

0

참고문헌

키워드

주제분류병리학

초록

Background: Streptococcus pneumoniae is a serious pathogen causing various infections in humans. We evaluated the serotype distribution and antimicrobial resistance of S. pneumoniae causing invasive pneumococcal disease (IPD) after introduction of pneumococcal conjugate vaccine (PCV)13 in Korea and investigated the epidemiological characteristics of multidrug-resistant (MDR) isolates. Methods: S. pneumoniae isolates causing IPD were collected from 16 hospitals in Korea between 2017 and 2019. Serotyping was performed using modified sequential multiplex PCR and the Quellung reaction. Antimicrobial susceptibility tests were performed using the broth microdilution method. Multilocus sequence typing was performed on MDR isolates for epidemiological investigations. Results: Among the 411 S. pneumoniae isolates analyzed, the most prevalent serotype was 3 (12.2%), followed by 10A (9.5%), 34 (7.3%), 19A (6.8%), 23A (6.3%), 22F (6.1%), 35B (5.8%), 11A (5.1%), and others (40.9%). The coverage rates of PCV7, PCV10, PCV13, and pneumococcal polysaccharide vaccine (PPSV)23 were 7.8%, 7.8%, 28.7%, and 59.4%, respectively. Resistance rates to penicillin, ceftriaxone, erythromycin, and levofloxacin were 13.1%, 9.2%, 80.3%, and 4.1%, respectively. MDR isolates accounted for 23.4% of all isolates. Serotypes 23A, 11A, 19A, and 15B accounted for the highest proportions of total isolates at 18.8%, 16.7%, 14.6%, and 8.3%, respectively. Sequence type (ST)166 (43.8%) and ST320 (12.5%) were common among MDR isolates. Conclusions: Non-PCV13 serotypes are increasing among invasive S. pneumoniae strains causing IPD. Differences in antimicrobial resistance were found according to the specific serotype. Continuous monitoring of serotypes and antimicrobial resistance is necessary for the appropriate management of S. pneumoniae infections.

Abstract

Background: Streptococcus pneumoniae is a serious pathogen causing various infections in humans. We evaluated the serotype distribution and antimicrobial resistance of S. pneumoniae causing invasive pneumococcal disease (IPD) after introduction of pneumococcal conjugate vaccine (PCV)13 in Korea and investigated the epidemiological characteristics of multidrug-resistant (MDR) isolates. Methods: S. pneumoniae isolates causing IPD were collected from 16 hospitals in Korea between 2017 and 2019. Serotyping was performed using modified sequential multiplex PCR and the Quellung reaction. Antimicrobial susceptibility tests were performed using the broth microdilution method. Multilocus sequence typing was performed on MDR isolates for epidemiological investigations. Results: Among the 411 S. pneumoniae isolates analyzed, the most prevalent serotype was 3 (12.2%), followed by 10A (9.5%), 34 (7.3%), 19A (6.8%), 23A (6.3%), 22F (6.1%), 35B (5.8%), 11A (5.1%), and others (40.9%). The coverage rates of PCV7, PCV10, PCV13, and pneumococcal polysaccharide vaccine (PPSV)23 were 7.8%, 7.8%, 28.7%, and 59.4%, respectively. Resistance rates to penicillin, ceftriaxone, erythromycin, and levofloxacin were 13.1%, 9.2%, 80.3%, and 4.1%, respectively. MDR isolates accounted for 23.4% of all isolates. Serotypes 23A, 11A, 19A, and 15B accounted for the highest proportions of total isolates at 18.8%, 16.7%, 14.6%, and 8.3%, respectively. Sequence type (ST)166 (43.8%) and ST320 (12.5%) were common among MDR isolates. Conclusions: Non-PCV13 serotypes are increasing among invasive S. pneumoniae strains causing IPD. Differences in antimicrobial resistance were found according to the specific serotype. Continuous monitoring of serotypes and antimicrobial resistance is necessary for the appropriate management of S. pneumoniae infections.

참고문헌 (41)

  1. Manoharan A, "Invasive pneumococcal disease in children aged younger than 5 years in India : a surveillance study", Lancet Infect Dis, 17, pp.305~312 (2017)
  2. 박동철, "Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016", Annals of Laboratory Medicine, 39(6), pp.537~544 (2019), 대한진단검사의학회[DOI]
  3. Croney CM, "Invasive and noninvasive Streptococcus pneumoniae capsule and surface protein diversity following the use of a conjugate vaccine", Clin Vaccine Immunol, 20, pp.1711~1718 (2013)
  4. Diawara I, "Invasive pneumococcal disease among children younger than 5 years of age before and after introduction of pneumococcal conjugate vaccine in Casablanca, Morocco", Int J Infect Dis, 40, pp.95~101 (2015)
  5. Moreno J, "Molecular characterization of Latin American invasive Streptococcus pneumoniae serotype 19A isolates", Vaccine, 38, pp.3524~3530 (2020)
  6. 김충종, "Serotype Distribution and Antimicrobial Susceptibilities of Invasive Streptococcus pneumoniae Isolates from Adults in Korea from 1997 to 2012", Journal of Korean Medical Science, 31(5), pp.715~723 (2016), 대한의학회
  7. Kim SH, "Changes in serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates from adult patients in Asia : emergence of drug-resistant non-vaccine serotypes", Vaccine, 38, pp.6065~6073 (2020)
  8. Park D, "Evaluation of modified sequential multiplex PCR for Streptococcus pneumoniae serotyping", Jpn J Infect Dis, 72, pp.224~227 (2019)
  9. Habib M, "Capsular serotyping of Streptococcus pneumoniae using the Quellung reaction", J Vis Exp, (84), pp.e51208~ (2014)
  10. Steenhoff AP, "Emergence of vaccine-related pneumococcal serotypes as a cause of bacteremia", Clin Infect Dis, 42, pp.907~914 (2006)
  11. CLSI, "Performance standards for antimicrobial susceptibility testing. 32nd ed. CLSI M100", Clinical and Laboratory Standards Institute, ~ (2022)
  12. Golden AR, "Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007-13", J Antimicrob Chemother, 70, pp.2199~2202 (2015)
  13. Enright MC, "A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease", Microbiology(Reading), 144, pp.3049~3060 (1998)
  14. Jolley KA, "Sequence type analysis and recombinational tests(START)", Bioinformatics, 17, pp.1230~1231 (2001)
  15. Wu CJ, "Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae in pre- and post- PCV7", 13 eras, Taiwan, 2002-2018, 2020, pp.11, 557404~
  16. Harboe ZB, "Impact of 13-valent pneumococcal conjugate vaccination in invasive pneumococcal disease incidence and mortality", Clin Infect Dis, 59, pp.1066~1073 (2014)
  17. Hink RK, "Comparison of PCV-10 and PCV-13 vaccine coverage for invasive pneumococcal isolates obtained across Canadian geographic regions, SAVE 2011 to 2017", Diagn Microbiol Infect Dis, 99, pp.115282~ (2021)
  18. Suaya JA, "Streptococcus pneumoniae serotype distribution and antimicrobial nonsusceptibility trends among adults with pneumonia in the United States, 2009-2017", J Infect, 81, pp.557~566 (2020)
  19. Ludwig G, "Serotype and clonal distribution dynamics of invasive pneumococcal strains after PCV13 introduction(2011-2016) : Surveillance data from 23 sites in Catalonia, Spain", PLoS One, 15, pp.e0228612~ (2020)
  20. Yanagihara K, "Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae associated with invasive pneumococcal disease among adults in Japan", Int J Infect Dis, 102, pp.260~268 (2021)
  21. Lee S, "Changes in serotype prevalence and antimicrobial resistance among invasive Streptococcus pneumoniae isolates in Korea, 1996-2008", J Med Microbiol, 62, pp.1204~1210 (2013)
  22. Park M, "Changes in the incidence of Streptococcus pneumoniae bacteremia and its serotypes over 10 years in one hospital in South Korea", Vaccine, 32, pp.6403~6407 (2014)
  23. Gaviria-Agudelo CL, "The effect of 13-valent pneumococcal conjugate vaccine on the serotype distribution and antibiotic resistance profiles in children with invasive pneumococcal disease", J Pediatric Infect Dis Soc, 6, pp.253~259 (2017)
  24. Levy C, "Changes in invasive pneumococcal disease spectrum after 13-valent pneumococcal conjugate vaccine implementation", Clin Infect Dis, 70, pp.446~454 (2020)
  25. Nakano S, "Nationwide surveillance of paediatric invasive and non-invasive pneumococcal disease in Japan after the introduction of the 13-valent conjugated vaccine, 2015-2017", Vaccine, 38, pp.1818~1824 (2020)
  26. Desmet S, "In-depth analysis of pneumococcal serotypes in Belgian children (2015-2018): diversity, invasive disease potential, and antimicrobial susceptibility in carriage and disease", Vaccine, 39, pp.372~379 (2021)
  27. Yun KW, "Emergence of serotype 10A-ST11189 among pediatric invasive pneumococcal diseases, South Korea, 2014-2019", Vaccine, 39, pp.5787~5793 (2021)
  28. Ubukata K, "Effects of pneumococcal conjugate vaccine on genotypic penicillin resistance and serotype changes, Japan, 2010-2017", Emerg Infect Dis, 24, pp.2010~2020 (2018)
  29. Imöhl M, "Association of serotypes of Streptococcus pneumoniae with age in invasive pneumococcal disease", J Clin Microbiol, 48, pp.1291~1296 (2010)
  30. Olarte L, "Emergence of multidrug-resistant pneumococcal serotype 35B among children in the United States", J Clin Microbiol, 55, pp.724~734 (2017)
  31. Lo SW, "Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era : an international whole-genome sequencing study", Lancet Infect Dis, 19, pp.759~769 (2019)
  32. Suzuki S, "Impact of the introduction of a 13-valent pneumococcal vaccine on pneumococcal serotypes in non-invasive isolates from 2007 to 2016 at a teaching hospital in Japan", J Med Microbiol, 68, pp.903~909 (2019)
  33. Zhao C, "Investigation of antibiotic resistance, serotype distribution, and genetic characteristics of 164 invasive Streptococcus pneumoniae from North China between April 2016 and October 2017", Infect Drug Resist, 13, pp.2117~2128 (2020)
  34. Moore CE, "Reduction of invasive pneumococcal disease 3 years after the introduction of the 13-valent conjugate vaccine in the Oxfordshire region of England", J Infect Dis, 210, pp.1001~1011 (2014)
  35. Tsai YT, "Nationwide surveillance of antimicrobial resistance in invasive isolates of Streptococcus pneumoniae in Taiwan from 2017 to 2019", J Microbiol Immunol Infect, 55, pp.215~224 (2022)
  36. Bao Y, "The changing phenotypes and genotypes of invasive pneumococcal isolates from children in Shenzhen during 2013-2017", Vaccine, 37, pp.7248~7255 (2019)
  37. Wang Q, "Serotype distribution of Streptococcus pneumoniae isolated from children hospitalized in Beijing Children’s Hospital(2013-2019)", Vaccine, 38, pp.7858~7864 (2020)
  38. Baek JY, "Prevalence of antimicrobial resistant Streptococcus pneumoniae serotype 11A isolates in Korea, during 2004-2013, due to the increase of multidrug-resistant clone, CC166", Infect Genet Evol, 38, pp.122~125 (2016)
  39. Park M, "Novel levofloxacin-resistant multidrug-resistant Streptococcus pneumoniae serotype 11A isolates, South Korea", Emerg Infect Dis, 22, pp.1978~1980 (2016)
  40. Wang X, "Molecular characterization of Streptococcus pneumoniae isolated from pediatric patients in Shanghai, China", Pediatr Pulmonol, 55, pp.2135~2141 (2020)
  41. Yun KW, "Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013", BMC Infect Dis, 18, pp.268~ (2018)

관련 논문AI추천

Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016권민정, 김선주, 김수현, 김시현, 김영리, 김유경, 김자영, 김종완, 김현수, 류남희, 문희원, 박경운, 박동철, 박철민, 서인범, 서헌석, 손용학, 송새암, 송원근, 신경섭, 신정환, 신종희, 용동은, 우광숙, 우혜인, 이규택, 이미경, 이미애, 이성규, 이재현, 이종윤, 이채훈, 이해경, 이희주, 장숙진, 장철훈, 정석훈, 정재우, 조지현, 홍기호, 황상현, Joseph Jeong대한진단검사의학회 · Annals of Laboratory Medicine2019 · 제39권 제6호Changes in Serotype of Streptococcus pneumoniae After the Introduction of the 13-Valent Pneumococcal Vaccine in a Homogenous Population on Jeju Island김영리, 오수현, 오현주, 유정래, 이근화, 허상택대한감염학회 · Infection and Chemotherapy2019 · 제51권 제1호Invasive Pneumococcal Diseases in Korean Adults After the Introduction of Pneumococcal Vaccine into the National Immunization Program이미숙대한감염학회 · Infection and Chemotherapy2023 · 제55권 제4호Distribution of Serotypes and Antibiotic Susceptibility Patterns Among Invasive Pneumococcal Diseases in Saudi ArabiaDabwan Khaled Homoud Mohammed, James John, Lakshmana K. Gowda, M. Marie Mohammed Ali, Pradeep Chikkabidare Shashidhar, Yazeed A. Al-Sherikh대한진단검사의학회 · Annals of Laboratory Medicine2014 · 제34권 제3호Nasopharyngeal Carriage Rate and Serotypes of Streptococcus pneumoniae and Antimicrobial Susceptibility in Healthy Korean Children Younger than 5 Years Old: Focus on Influence of Pneumococcal Conjugate Vaccination강진한, 권효진, 김경효, 이은경, 준자경, 최의연대한감염학회 · Infection and Chemotherapy2013 · 제45권 제1호The Changing Epidemiology of Childhood Pneumococcal Disease in Korea이환종, 최영준, 최은화대한감염학회 · Infection and Chemotherapy2013 · 제45권 제2호

이 간행물의 다른 논문 (22건)