Effect of Phellius linteus water extract on benign prostatic hyperplasia
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Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. As the old-age population is increasing recently,it is to our interest to observe the growing BPH within them. In BPH, the dihydrotestosterone (DHT) acts as promotes prostate growth. It inhibits enzyme 5α-reductase that is involved in the conversion of testosterone to the DHT activity which reduces the excessive prostate growth. Through experiments, the effects of Phellius linteus water extract performed on the BPH rats were induced by testosterone treatments. For 12 weeks, Sprague-Dawley rats were treated with testosterone for the induction of BPH. Rats were divided into four experimental groups: the not treated group (N), the testosterone injection and D.W treatment group (TN), the testosterone injection and Phellinus linteus treatment group (TP) and testosterone injection and finasteride treatment group (TF). Prostate weight, volume and weight ratio in the TP group and the TF group were significantly lower than the TN group. Testosterone and DHT levels in the TN group were significantly higher than that of the N group. And the TP group was significantly decreased than that of the TN group. While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation; the TP and TF groups showed trophic symptoms and were lined by flattened epithelial cells, thus, the stromal proliferation is relatively low as compared to the TN group. These suggest that Phellinus linteus water extracts may be an useful remedy for treating the benign prostatic hyperplasia.
Abstract
Benign prostatic hyperplasia (BPH) is one of the most common diseases among elderly men. As the old-age population is increasing recently,it is to our interest to observe the growing BPH within them. In BPH, the dihydrotestosterone (DHT) acts as promotes prostate growth. It inhibits enzyme 5α-reductase that is involved in the conversion of testosterone to the DHT activity which reduces the excessive prostate growth. Through experiments, the effects of Phellius linteus water extract performed on the BPH rats were induced by testosterone treatments. For 12 weeks, Sprague-Dawley rats were treated with testosterone for the induction of BPH. Rats were divided into four experimental groups: the not treated group (N), the testosterone injection and D.W treatment group (TN), the testosterone injection and Phellinus linteus treatment group (TP) and testosterone injection and finasteride treatment group (TF). Prostate weight, volume and weight ratio in the TP group and the TF group were significantly lower than the TN group. Testosterone and DHT levels in the TN group were significantly higher than that of the N group. And the TP group was significantly decreased than that of the TN group. While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation; the TP and TF groups showed trophic symptoms and were lined by flattened epithelial cells, thus, the stromal proliferation is relatively low as compared to the TN group. These suggest that Phellinus linteus water extracts may be an useful remedy for treating the benign prostatic hyperplasia.
참고문헌 (25)
- Wei JT, "Urologic diseases in America project: benign prostatic hyperplasia", J Urol, 173, pp.1256~1261 (2005)
- Zhang Y, "Changing patterns of bladder cancer in the USA: evidence of heterogeneous disease", BJU Int, 109, pp.52~56 (2012)
- Parsons JK, "Benign prostatic hyperplasia and male lower urinary tract symptoms: epidemiology and risk factors", Curr Bladder Dysfunct Rep, 5, pp.212~218 (2010)
- Arrighi HM, "Natural history of benign prostatic hyperplasia and risk of prostatectomy", The Baltimore Longitudinal Study of Aging. Urology, 38, pp.4~8 (1991)
- Miano R, "Treatment options for benign prostatic hyperplasia in older men", Med Sci Monit, 14, pp.R94~R102 (2008)
- Clark RV, "Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5α -reductase inhibitor", J Clin Endocrinol Metab, 89, pp.2179~2184 (2004)
- Isaacs JT, "Antagonistic effect of androgen on prostatic cell death", Prostate, 5, pp.545~557 (1984)
- Nixon P, "New clinical trial of medical therapy for benign prostatic hyperplasia", Drug Benefit Trends, 9, pp.44~45 (1997)
- Jang H, "Anthocyanin extracted from black soybean reduces prostate weight and promotes apoptosis in the prostatic hyperplasia-induced rat model", J Agric Food Chem, 58, pp.12686~12691 (2010)
- Isaacs JT, "Etiology and disease process of benign prostatic hyperplasia", Prostate Suppl, 2, pp.33~50 (1989)
- Tsuji T, "Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice", PLoS One, 5, pp.e9885~ (2010)
- Sliva D, "Medicinal mushroom Phellinus linteus as an alternative cancer therapy", Exp Ther Med, 1, pp.407~411 (2010)
- Kim HM, "Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus", Int J Immunopharmacol, 18, pp.295~303 (1996)
- Kojima H, "A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases", Radiat Med, 24, pp.139~142 (2006)
- Suzuki S, "Influence of shiitake (Lentinus edodes) on human serum cholesterol", Proceedings of the 9th International Scientific Congress on the Cultivation of Edible Fungi, pp.463~647 (1976), Mushroom Research Institute in Japan
- Kim BC, "The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta", Nrf2, J Ethnopharmacol, pp.2007, 113[DOI]
- Choi YH, "Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus", Biol Pharm Bull, 29, pp.1360~1365 (2006)
- Steel RG, "Principles and Procedures of Statistics: A Biometrical Approach" (1996), McGraw-Hill
- Jung-Ran Noh, "A Phellinus baumii Extract Reduces Obesity in High-Fat Diet-Fed Mice and Absorption of Triglyceride in Lipid-Loaded Mice", Journal of Medicinal Food, 14(3), pp.209~218 (2011), 한국식품영양과학회
- Choi JS, "Consumption of barley beta-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet", MOLECULAR NUTRITION FOOD RESEARCH, 54(7), pp.1004~1013 (2010), WILEY-BLACKWELL
- Song YS, "Antiangiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus", J Ethnopharmacol, 88, pp.113~116 (2003)
- Jeon TI, "Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats", Biotechnol Lett, 25, pp.2093~2096 (2003)
- Liang CH, "Antioxidant properties of solid-state fermented adlay and rice by Phellinus linteus", Food Chem, 116, pp.841~845 (2009)
- Zhu T, "Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells", Br J Cancer, 96, pp.583~590 (2007)
- 조소현, "蜂毒藥鍼이 前立腺肥大症 Rat에 미치는 영향", 대한한방내과학회지, 31(1), pp.166~176 (2010), 대한한방내과학회