간세포성장인자가 골결손부의 치유에 미치는 영향
The effect of hepatocyte growth factor for repair of the bone defect
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Abstract
Bone healing plays an important role in orthognathic and craniofacial surgery. Bone tissue repair and regeneration are regulated by an array of growth and morphogenetic factors. Bone formation and remodeling require continuous generation of osteoprogenitor cells from bone marrow stromal cells, which generate and respond to a variety of growth factors with putative roles in hematopoiesis and mesenchymal differentiation. In this study, the efficacy of a single application of hepatocyte growth factor to promote bone regeneration in 5-mm experimental calvarial defects of adult male rats was assessed histologically and immunohistochemically. The result of the experimental site were compared with those of the contralateral contral side. None of the control and experimental bone defects demonstrated complete bone closure. Bone regeneration was found close th the margine and central part of the defects. At 1, 2 weeks, there were found much significant cellural mitotic activity and many inflammatory cells and osteoblasts on the experimental site than control site. At 4, 6 weeks, new bone apposition was founded in both site but, more apposition was seen at experimental site. At 8, 12 weeks, also, some differences was found that more apposition of new bone and collagen fiber was seen on experimental site. Our results have some possibility that HGF do a early positive role to repair the bone defect. More study will be needed.
참고문헌 (36)
- "Reconstruction of calvarial defects with anorganic bovine bone mineral" (1993)
- "Autogenous bone grafts versus alloplastic material in maxillofacial surgery" (1982)
- "Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro", 93, pp.7644~ (1996)
- "Fibroblast growth factor-2 induces hepatocyte growth factor", scatter factor expression in osteoblasts, 1999, pp.140, 1069~
- "The effect of hepatocyte growth factor on the behavior of osteoclasts", 212, pp.334~ (1995)
- "Cortisol decreases hepatocyte growth factor levels in human osteoblast-like cells", 66, pp.108~ (2000)
- "Hepatocyte growth factor is consititutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis", 89, pp.1560~ (1997)
- "Hepatocyte growth factor", scatter factor is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells, 1998, pp.26, 885~
- "Enhancement by hepatocyte growth factor of bone and cartilage formation during embryonic mouse mandibular development in vitro", 44, pp.935~ (1999)
- "Cooperative Actions of Hepatocyte Growth Factor and 1 25-Dihydroxy vitamin D3 in Osteoblastic Differation of Human Vertebral Bone Marrow Stromal Cells", 31, pp.269~ (2002)
- "Hepatocyte growth factor", scatter factor modulates cell motility, proliferation, and proteoglycan synthesis of chondrocytes, 1995, pp.129, 1411~
- "Hepatocyte growth factor facilitates cartilage repair. Full thickness articular cartilage defect studied in rabbit knees", 68, pp.474~ (1997)
- "Hydroxyapatite coated with hepatocyte growth factor stimulates human osteoblasts in vitro", 82, pp.457~ (2000)
- ":Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth", pp.629~
- "Induction of liver growth in normal mice by infusion of hepatocyte growth factor", scatter factor, 1995, pp.268, 380~
- "Scatter factor", hepatocyte growth factor as a regulator of skeletal muscle and neural crest development, 1996, pp.93, 5866~
- "Simultaneous or delayed administration of hepatocyte growth factor equally repress the fibrotic change in murine lung injury induced by bleomycric a morphogenic study", 158, pp.1937~ (1997)
- "Developmental roles of HGF", SF and its receptor, c-Met tyrosine kinase, 1998, pp.8, 404~
- "Hepatocyte growth factor and the kidney: it is just not for the liver", 188, pp.225~ (1999)
- "The many faces of hepatocyte growth factor from hepatopoiesis", 129, pp.1177~ (1995)
- "Hepatocyte growth factor as a tissue organizer for organogenesis and regeneration", 239, pp.639~ (1997)
- "Hepatocyte growth factor. mesenchymal signal for epithelial homeostasis", 54, pp.1392~ (1998)
- "Potential angiogenic effect of scatter factor", hepatocyte growth factor via induction of vascular endothelial growth factor the case for paracrine amplification of angiogenesis, 1998, pp.97, 381~97
- "Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy", 33, pp.1379~ (1999)
- "Reciprocal balance of hepatocyte growth factor and transforming growth factor-β1 in renal fibrosis in mice", 57, pp.937~ (2000)
- "Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats", 118, pp.643~ (1995)
- "Anti-fibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats", 24, pp.638~ (1996)
- "Roles of hepatocyte growth factor and receptor c-Met during gastric ulcer healing in rats", 113, pp.1858~ (1997)
- "Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease", 113, pp.1827~ (1998)
- "Hepatocyte growth factor prevents endotoxin-induced lethal hepatic failure in mice", 30, pp.151~ (1999)
- "Hepatocyte growth factor leads to recovery from alcohol-induced fatty liver in rats", 103, pp.313~ (1999)
- "Hepatocyte growth factor gene therapy of liver chirrhosis in rats", 5, pp.226~ (1999)
- "Effect of hepatocyte growth factor on tacrolimus-induced nephrotoxicity in spontaneously hypertensive rats", 12, pp.27~ (1999)
- "Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product", pp.802~
- "Coadministration of basic fibroblast growth factor and sucrose octasulfate facilitates rat dorsal flap survival and viability", 103, pp.941~ (1999)
- "Repair of crainotomy defect using bone marrow stromal cells", 66, pp.1272~ (1998)