약물 알레르기 꼬리표 떼기
Drug Allergy Delabeling
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Drug allergy labels are critical for ensuring patient safety; however, unverified labels established without a rigorous diagnostic process can lead to suboptimal medication use, treatment failures, increased adverse drug reactions, and higher healthcare costs. In particular, unconfirmed penicillin allergy labels are strongly linked to the inappropriate use of broadspectrum antibiotics, contributing to the rise of multidrug-resistant infections. The process of drug allergy delabeling enables many patients to safely use the medication in question, thereby facilitating the appropriate use of antibiotics and reducing unnecessary avoidance. Such delabeling is particularly vital as part of antimicrobial stewardship programs, as it enhances patient outcomes while decreasing healthcare expenses. Moving forward, the development of standardized procedures, enhanced awareness among patients and healthcare providers, and the implementation of validated risk-stratification methods is essential for more accurate and efficient drug allergy delabeling. These advancements will help mitigate the adverse effects of inaccurate labels and support optimal patient care.
Abstract
Drug allergy labels are critical for ensuring patient safety; however, unverified labels established without a rigorous diagnostic process can lead to suboptimal medication use, treatment failures, increased adverse drug reactions, and higher healthcare costs. In particular, unconfirmed penicillin allergy labels are strongly linked to the inappropriate use of broadspectrum antibiotics, contributing to the rise of multidrug-resistant infections. The process of drug allergy delabeling enables many patients to safely use the medication in question, thereby facilitating the appropriate use of antibiotics and reducing unnecessary avoidance. Such delabeling is particularly vital as part of antimicrobial stewardship programs, as it enhances patient outcomes while decreasing healthcare expenses. Moving forward, the development of standardized procedures, enhanced awareness among patients and healthcare providers, and the implementation of validated risk-stratification methods is essential for more accurate and efficient drug allergy delabeling. These advancements will help mitigate the adverse effects of inaccurate labels and support optimal patient care.
참고문헌 (26)
- Edwards IR, "Adverse drug reactions : definitions, diagnosis, and management", Lancet, 356, pp.1255~1259 (2000)
- Formica D, "The economic burden of preventable adverse drug reactions : a systematic review of observational studies", Expert Opin Drug Saf, 17, pp.681~695 (2018)
- Wilkerson RG, "Drug hypersensitivity reactions", Immunol Allergy Clin North Am, 43, pp.473~489 (2023)
- Stone CA Jr, "The challenge of de-labeling penicillin allergy", Allergy, 75, pp.273~288 (2020)
- Norton AE, "Antibiotic allergy in pediatrics", Pediatrics, 141, pp.e20172497~ (2018)
- Vyles D, "Parent-reported penicillin allergy symptoms in the pediatric emergency department", Acad Pediatr, 17, pp.251~255 (2017)
- Ibia EO, "Antibiotic rashes in children : a survey in a private practice setting", Arch Dermatol, 136, pp.849~854 (2000)
- Macy E, "Are cephalosporins safe for use in penicillin allergy without prior allergy evaluation?", J Allergy Clin Immunol Pract, 6, pp.82~89 (2018)
- Blumenthal KG, "Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy : population based matched cohort study", BMJ, 361, pp.k2400~ (2018)
- Blumenthal KG, "The impact of a reported penicillin allergy on surgical site infection risk", Clin Infect Dis, 66, pp.329~336 (2018)
- MacFadden DR, "Impact of reported beta-lactam allergy on inpatient outcomes : a multicenter prospective cohort study", Clin Infect Dis, 63, pp.904~910 (2016)
- Briody VA, "Use of cefazolin for group B Streptococci prophylaxis in women reporting a penicillin allergy without anaphylaxis", Obstet Gynecol, 127, pp.577~583 (2016)
- Trubiano JA, "Antimicrobial allergy ‘labels’ drive inappropriate antimicrobial prescribing : lessons for stewardship", J Antimicrob Chemother, 71, pp.1715~1722 (2016)
- Li M, "A real-time prospective evaluation of clinical pharmaco-economic impact of diagnostic label of ‘penicillin allergy’ in a UK teaching hospital", J Clin Pathol, 67, pp.1088~1092 (2014)
- Picard M, "Treatment of patients with a history of penicillin allergy in a large tertiary-care academic hospital", J Allergy Clin Immunol Pract, 1, pp.252~257 (2013)
- Wu JH, "Potential negative effects of antimicrobial allergy labelling on patient care : a systematic review", Can J Hosp Pharm, 71, pp.29~35 (2018)
- Blumenthal KG, "The cost of penicillin allergy evaluation", J Allergy Clin Immunol Pract, 6, pp.1019~1027 (2018)
- Vyles D, "Antibiotic use after removal of penicillin allergy label", Pediatrics, 141, pp.e20173466~ (2018)
- Sacco KA, "Clinical outcomes following inpatient penicillin allergy testing : a systematic review and meta-analysis", Allergy, 72, pp.1288~1296 (2017)
- Trubiano J, "Antimicrobial stewardship’s new weapon? A review of antibiotic allergy and pathways to ‘delabeling’", Curr Opin Infect Dis, 26, pp.526~537 (2013)
- Trubiano JA, "Penicillin allergy is not necessarily forever", JAMA, 318, pp.82~83 (2017)
- Huang KG, "The impact of reported beta-lactam allergy in hospitalized patients with hematologic malignancies requiring antibiotics", Clin Infect Dis, 67, pp.27~33 (2018)
- Devchand M, "Pathways to improved antibiotic allergy and antimicrobial stewardship practice : the validation of a beta-lactam antibiotic allergy assessment tool", J Allergy Clin Immunol Pract, 7, pp.1063~1065 (2019)
- Staicu ML, "Implementation of a penicillin allergy screening tool to optimize aztreonam use", Am J Health Syst Pharm, 73, pp.298~306 (2016)
- Confino-Cohen R, "Oral challenge without skin testing safely excludes clinically significant delayed-onset penicillin hypersensitivity", J Allergy Clin Immunol Pract, 5, pp.669~675 (2017)
- Tucker MH, "Amoxicillin challenge without penicillin skin testing in evaluation of penicillin allergy in a cohort of Marine recruits", J Allergy Clin Immunol Pract, 5, pp.813~815 (2017)
