인간 비만세포에서 무환자나무 열매 추출물의 항알러지 효과
Anti-allergic Effect of Sapindus Mukorossi Fruits Extract in Human Mast Cells
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초록
This study was performed to examine the anti-allergic effect of Sapindu mukorossi fruits extracts (SME). Primarily, the inhibitory effect of SME on allergic response was investigated. The effect of SME on human mast cells (LUVA cells) was analyzed via ELISA and western blotting Specifically, cell viability, histamine as marker of degranulation, production of inflammatory cytokines, and protein phosphorylation were evaluated. Results showed that SME suppressed histamine release, decreased cytokine such as TNF-α, IL-1β, IL-4 and IL-6 in IgE-stimulated LUVA cells. Furthermore, SME significantly decreased the phosphorylation of Lyn, Syk and MAPKs in the LUVA cells. Our results indicate that SME has anti-allergic effect through inhibition of degranulation and production of cytokines.
Abstract
This study was performed to examine the anti-allergic effect of Sapindu mukorossi fruits extracts (SME). Primarily, the inhibitory effect of SME on allergic response was investigated. The effect of SME on human mast cells (LUVA cells) was analyzed via ELISA and western blotting Specifically, cell viability, histamine as marker of degranulation, production of inflammatory cytokines, and protein phosphorylation were evaluated. Results showed that SME suppressed histamine release, decreased cytokine such as TNF-α, IL-1β, IL-4 and IL-6 in IgE-stimulated LUVA cells. Furthermore, SME significantly decreased the phosphorylation of Lyn, Syk and MAPKs in the LUVA cells. Our results indicate that SME has anti-allergic effect through inhibition of degranulation and production of cytokines.
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