한국인에서 중중 자궁내막증 감수성과 HLA-A, B항원의 연관성 연구
Association of HLA-A, B antigens with Susceptibility to Advanced Endometriosis in Koreans
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Abstract
Background : Endometriosis is defined as the presence of endometrial tissue outside the uterus, causing diverse diseases, including infertility, pelvic pain, dysmenorrhea, and constipation. While there is a growing body of evidence that genetic and immunologic factors play important roles in the pathogenesis of the disease, HLA-A, B antigens have been reported to be associated with the risk of endometriosis in the Japanese population. This study was performed to determine whether the susceptibility to advanced endometriosis is also associated with HLA-A, B antigens in the Korean population, which is the closest ethnic group to Japanese. Methods : We recruited 50 Korean patients with advanced endometriosis confirmed by surgical and histolological examinations. Distribution of HLA-A and B antigens was compared with that of 200 unrelated ethnically matched individuals. HLA-A and B genotyping was carried out using a PCRsequence specific oligonucleotide hybridization method. Results : An increased frequency of B39 was observed in endometriosis patients compared with control subjects, but the difference was not statistically significant after correcting for multiple comparisons (4.0% patients vs 0.8% controls, OR=5.5, 95% CI=1.21-25.04, P=0.03, Pc=not significant). No significant differences were found between the patients with endometriosis and the general control group with regards to the distribution of other HLA-A and B antigens. Conclusions : The findings of the present study suggest that the susceptibility to advanced endometriosis, unlike in the Japanese population, is not associated with HLA-A, B antigens in the Korean population. (Korean J Lab Med 2008;28:118-23)
참고문헌 (32)
- Missmer SA, "The epidemiology of endometriosis", Obstet Gynecol Clin North Am, 30, pp.1~19 (2003)
- Simpson JL, "Heritability and molecular genetic studies of endometriosis", Ann N Y Acad Sci, 955, pp.239~251 (2002)
- Dmowski WP, "Deficient cellular immunity in endometriosis", Am J Obstet Gynecol, 141, pp.377~383 (1981)
- Garzetti GG, "Natural killer cell activity in endometriosis: correlation between serum estradiol levels and cytotoxicity", Obstet Gynecol, 81, pp.665~668 (1993)
- Witz CA, "Current concepts in the pathogenesis of endometriosis", Clin Obstet Gynecol, 42, pp.566~585 (1999)
- Gleicher N, "Is endometriosis an autoimmune disease?", Obstet Gynecol, 70, pp.115~122 (1987)
- Confino E, "Peritoneal fluid and serum autoantibody levels in patients with endometriosis", Fertil Steril, 53, pp.242~245 (1990)
- Moen M, "Distribution of HLA-antigens among patients with endometriosis", Acta Obstet Gynecol Scand Suppl, 123, pp.25~27 (1984)
- Simpson JL, "HLA associations in endometriosis", Am J Obstet Gynecol, 148, pp.395~397 (1984)
- Maxwell C, "No HLA-DR specificity is associated with endometriosis", Tissue Antigens, 34, pp.145~147 (1989)
- Roszkowski PI, "Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles", Hum Reprod, 20, pp.970~973 (2005)
- Ishii K, "Studies on the human leukocyte antigen class I antigens in Japanese patients with macroscopically diagnosed endometriosis", Gynecol Obstet Invest, 54, pp.150~153 (2002)
- Ishii K, "Studies on the human leukocyte antigen-DR in patients with endometriosis: genotyping of HLA-DRB1 alleles", Hum Reprod, 17, pp.560~563 (2002)
- Ishii K, "Associations between patients with endometriosis and HLA class II; the analysis of HLA-DQB1 and HLA-DPB1 genotypes", Hum Reprod, 18, pp.985~959 (2003)
- Kitawaki J, "Association of HLA class I and class II alleles with susceptibility to endometriosis", Hum Immunol, 63, pp.1033~1038 (2002)
- American society for reproductive medicine, "Revised American society for reproductive medicine classification of endometriosis", Fertil Steril, 67, pp.817~821 (1997)
- 노은연, "Dynal RELI™ SSO HLA-B Test 키트를 이용한 HLA-B 형별검사의 Ambiguity 분석 및 한국형 해석 프로그램의 개발", Annals of Laboratory Medicine, 23(4), pp.268~278 (2003), 대한진단검사의학회
- Svejgaard A, "HL-A antigens and disease. Statistical and genetical considerations", Tissue Antigens, 4, pp.95~105 (1974)
- Whang DH, "No association between HLA-DRB1 alleles and susceptibility to advanced stage endometriosis in a Korean population", Human Reprod, 21, pp.129~133 (2006)
- Tokunaga K, "The migration and dispersal of east Asian population as viewed from HLA genes and haplotypes in: The evolution and dispersal of modern humans in Asia", pp.599~611 (1992), Hokusen-sha
- Tokunaga K, "On the origin and dispersal of East Asian populations as viewed from HLA haplotypes in: Prehistoric mongoloid dispersals", pp.87~197 (1996), Oxford University Press
- An J, "A study on HLA extended haplotype in a group of northern Chinese of Han nationality", Proceedings of the Eleventh International Histocompatibility Workshop and Conference, 통권 : 2, pp.294~296 (1991), Oxford University Press
- Imanish T, "Allele and haplotype frequencies for HLA and complement loci in various ethnic groups", Proceedings of the Eleventh International Histocompatibility Workshop and Conference, 통권 : 2, pp.1065~1220 (1992), Oxford University Press
- Park MH, "HLA haplotypes in Koreans based on 107 families", Tissue Antigens, 51, pp.347~355 (1998)
- Kitawaki J, "Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata", Hum Reprod, 16, pp.51~55 (2001)
- Wang Z, "Polymorphisms in the estrogen receptor beta gene but not estrogen receptor alpha gene affect the risk of developing endometriosis in a Japanese population", Fertil Steril, 81, pp.1650~1656 (2004)
- Arumugam K, "Endometriosis and race", Aust N Z J Obstet Gynaecol, 32, pp.164~165 (1992)
- Sangi-Haghpeykar H, "Epidemiology of endometriosis among parous women", Obstet Gynecol, 85, pp.983~992 (1995)
- Zondervan KT, "What makes a good casecontrol study? Design issues for complex traits such as endometriosis", Hum Reprod, 17, pp.1415~1423 (2002)
- Arici A, "Interleukin-8 concentration in peritoneal fluid of patients with endometriosis and modulation of interleukin-8 expression in human mesothelial cells", Mol Hum Reprod, 2, pp.40~45 (1996)
- Thornton JG, "The relationship between laparoscopic disease, pelvic pain and infertility; an unbiased assessment", Eur J Obstet Gynecol Reprod Biol, 74, pp.57~62 (1997)
- Nisolle M, "Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities", Fertil Steril, 68, pp.585~596 (1997)