가토안에서 전방내 트리암시놀론의 항염증 효과
Effect of Intracameral Triamcinolone to Control Inflammation in Rabbit Eyes
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목적: 백내장수술 중 후낭파열이 발생하였을 경우 전방내 유리체 제거를 위해 주입된 트리암시놀론의 항염증 효과 및 합병증에 대해알아보고자 하였다. 대상과 방법: 백색 가토 20마리의 수정체를 제거하고 수정체 후낭을 인위적으로 파열시켜 전방내로 유리체의 탈출을 유도한 후 전방내유리체절제술을 시행하였다. 수술 중 전방내 트리암시놀론을 주입한 군과 주입하지 않은 군에서 수술 후 1, 3, 7, 14, 28일에 전방내방수흐림을 laser flare meter로 측정하여 비교하였다. 결과: 술 후 14, 28일에 트리암시놀론을 사용하여 유리체절제술을 시행한 군이 트리암시놀론을 사용하지 않은 군에 비해 유의하게낮은 방수흐림 소견을 보였다(p＜0.05). 두 군 모두에서 합병증은 관찰되지 않았다. 결론: 전방내 유리체 제거를 위해 주입된 트리암시놀론은 완전한 유리체 제거에 유용할 뿐만 아니라 추가적인 합병증 없이 항염증효과를 얻을 수 있을 것으로 생각된다.
Abstract
Purpose: To investigate the effect of intracameral triamcinolone on the control of inflammation with rupture of the posterior lens capsule during cataract surgery in rabbit eyes. Methods: Twenty rabbit eyes were subjected to experimentally induced rupture of the posterior lens capsule and prolapse of the vitreous body into the anterior chamber. After anterior vitrectomy with and without triamcinolone, aqueous flare was measured with a laser flare meter on days 1, 3, 7, 14 and 28. Results: Vitrectomized eyes with triamcinolone showed a less marked increase in postoperative aqueous flare intensity on days 14 and 28 than did those without triamcinolone (p＜0.05). Conclusions: Intracameral injection of triamcinolone was beneficial for visualizing the prolapsed vitreous in the anterior chamber and for helping to control the postoperative inflammation without adverse effects.
참고문헌 (23)
- Vajpayee RB, "Management of posterior capsule tears", Surv Ophthalmol, 45, pp.473~488 (2001)
- Akura J, "Management of posterior capsule rupture during phacoemulsification using the dry technique", J Cataract Refract Surg, 27, pp.982~989 (2001)
- Yamakiri K, "Intracameral triamcinolone helps to visualize and remove the vitreous body in anterior chamber in cataract surgery", Am J Ophthalmol, 138, pp.650~653 (2004)
- Burk SE, "Visualizing vitreous using Kenalog suspension", J Cataract Refract Surg, 29, pp.645~651 (2003)
- Tan DT, "Randomized clinical trial of Surodex steroid drug delivery system for cataract surgery: anterior versus posterior placement of two Surodex in the eye", Ophthalmology, 108, pp.2172~2181 (2001)
- Karalezli A, "Intracameral triamcinolone acetonide to control postoperative inflammation following cataract surgery with phacoemulsification", Acta Ophthalmol, 86, pp.183~187 (2008)
- Gills JP, "Effect of intracameral triamcinolone to control inflammation following cataract surgery", J Cataract Refract Surg, 31, pp.1670~1671 (2005)
- Walker TD, "Benzalkonium toxicity", Clin Experiment Ophthalmol, 32, pp.657~ (2004)
- Morrison VL, "Intravitreal toxicity of the kenalog vehicle (benzyl alcohol) in rabbits", Retina, 26, pp.339~344 (2006)
- Garcia-Arumi J, "Comparison of different techniques for purification of triamcinolone acetonide suspension for intravitreal use", Br J Ophthalmol, 89, pp.1112~1114 (2005)
- Nishimura A, "Isolating triamcinolone acetonide particles for intravitreal use with a porous membrane filter", Retina, 23, pp.777~779 (2003)
- Foster A, "The impact of Vision 2020 on global blindness", Eye, 19, pp.1133~1135 (2005)
- Misra A, "Incidence of intraoperative complications during phacoemulsification in vitrectomized and nonvitrectomized eyes: prospective study", J Cataract Refract Surg, 31, pp.1011~1014 (2005)
- Oh JY, "Short-term effect of intracameral triamcinolone acetonide on corneal endothelium using the rabbit model", Eye, 21, pp.812~818 (2007)
- Chang YS, "Triamcinolone acetonide suspension toxicity to corneal endothelial cells", J Cataract Refract Surg, 32, pp.1549~1555 (2006)
- Jonas JB, "Intraocular availability of triamcinolone acetonide after intravitreal injection", Am J Ophthalmol, 137, pp.560~562 (2004)
- Beer PM, "Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection", Ophthalmology, 110, pp.681~686 (2003)
- McCuen BW II, "The lack of toxicity of intravitreally administered triamcinolone acetonide", Am J Ophthalmol, 91, pp.785~788 (1981)
- Jonas JB, "Concentration of intravitreally injected triamcinolone acetonide in aqueous humour", Br J Ophthalmol, 86, pp.1066~ (2002)
- Enaida H, "Submacular deposition of triamcinolone acetonide after triamcinolone-assisted vitrectomy", Am J Ophthalmol, 135, pp.243~246 (2003)
- O'Brien ET, "Dexamethasone inhibits trabecular cell retraction", Exp Eye Res, 62, pp.675~688 (1996)
- 류시일, "트리암사놀론이 배양된 사람 섬유주세포의 증식에 미치는 영향", 대한안과학회지, 47(4), pp.655~660 (2006), 대한안과학회
- Moshfeghi DM, "Acute endophthalmitis following intravitreal triamcinolone acetonide injection", Am J Ophthalmol, 136, pp.791~796 (2003)