만성피로증후군에 대한 소요산(逍遙散)과 그 변방(變方)의 효과: 메타분석을 통한 체계적인 문헌고찰
Effectiveness of Soyo-san (Xiaoyao-san) and its Modifications on Chronic Fatigue Syndrome: a Systematic Review and Meta-analysis
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The purpose of this review is to confirm whether Soyo-san (Xiaoyao-san) and its modifications is effective on alleviating clinical symptoms in chronic fatigue syndrome (CFS) patients. We collected clinical trials (randomized controlled trial, quasi-randomized controlled trial, controlled clinical trial) to investigate the effects of Soyo-san and its modifications on general symptoms, fatigue, depression and anxiety in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found studies to conform with prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified based on the interventions in experimental and control group. Eight randomized controlled trials and one controlled clinical trial (total 921 participants) were eligible and their results were synthesized in the meta analysis. The synthesis showed a considerable effect of Soyo-san and its modifications on improvement of general symptoms (relative risk 0.27 [95% CI 0.19 to 0.39], Z=7.03, P<0.00001; I2=0%) and fatigue severity (SMD –1.20 [95% CI –1.46 to –0.93], Z=8.78, P<0.00001; I2=52%) in CFS patients, while Effect on depression and anxiety were inconclusive. We found that Soyo-san and its modifications were effective for improvement of general symptoms and fatigue severity in CFS post-treatment.
Abstract
The purpose of this review is to confirm whether Soyo-san (Xiaoyao-san) and its modifications is effective on alleviating clinical symptoms in chronic fatigue syndrome (CFS) patients. We collected clinical trials (randomized controlled trial, quasi-randomized controlled trial, controlled clinical trial) to investigate the effects of Soyo-san and its modifications on general symptoms, fatigue, depression and anxiety in CFS patients. The databases used for data retrieval were Pubmed, Central Cochrane, Embase, CNKI, CQVIP, Wanfang, CiNii, OASIS, RISS, and Koreamed. We performed selection/exclusion process from the found studies to conform with prespecified criteria, and assessed the final included trials according to the Cochrane risk of bias tool. The included studies were classified based on the interventions in experimental and control group. Eight randomized controlled trials and one controlled clinical trial (total 921 participants) were eligible and their results were synthesized in the meta analysis. The synthesis showed a considerable effect of Soyo-san and its modifications on improvement of general symptoms (relative risk 0.27 [95% CI 0.19 to 0.39], Z=7.03, P<0.00001; I2=0%) and fatigue severity (SMD –1.20 [95% CI –1.46 to –0.93], Z=8.78, P<0.00001; I2=52%) in CFS patients, while Effect on depression and anxiety were inconclusive. We found that Soyo-san and its modifications were effective for improvement of general symptoms and fatigue severity in CFS post-treatment.
참고문헌 (27)
- Jorgensen R, "Chronic fatigue : An evolutionary concept analysis", J Adv Nurs, 63(2), pp.199~207 (2008)
- Fukuda K, "The chronic fatigue syndrome : A comprehensive approach to its definition and study", Ann Intern Med, 121, pp.953~959 (1994)
- 손창규, "Review of the Prevalence of Chronic Fatigue Worldwide", 대한한의학회지, 33(2), pp.25~33 (2012), 대한한의학회[DOI]
- Martin A, "The relationship between chronic fatigue and somatization syndrome : A general population survey", J Psychosom Res, 63(2), pp.147~156 (2007)
- "Treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)" (2019)[URL]
- Jones JF, "Complementary and alternative medical therapy utilization by people with chronic fatiguing illnesses in the United States", BMC Complement Altern Med, 7, pp.12~ (2007)
- 김지원, "만성피로의 한의임상진료현황에 대한 조사 연구", 동의생리병리학회지, 32(2), pp.126~133 (2018), 한의병리학회[DOI]
- Yang G, "Standardization and unification of the terms and conditions used for diagnosis in oriental medicine(Ⅱ)", Korea Inst Orient Med, 155~157 (1996)
- Kim J, "Korean medicine clinical practice guideline for functional dyspepsia", the society of internal Korean medicine, 25~26 (2017)
- Hanna Lee, "Effect of Prognosis Awareness on the Survival and Quality of Life of Terminally Ill Cancer Patients: A Prospective Cohort Study", Korean Journal of Family Medicine, 41(2), pp.91~97 (2020), 대한가정의학회[DOI]
- Kim S, "NECA’s guidance for undertaking systematic reviews and meta-analyses for intervention", National Evidence-based Healthcare Collaborating Agency, 79~91 (2011)
- "Cochrane Handbook for Systematic Reviews of Interventions version 6.0" (2019)[URL]
- Mei C, "The Clinical Study of Combined Therapy of Xiao Yao San Jia Wei and Massage in the Treatment of Chronic Fatigue Syndrome Caused by Liver-depression and Spleen-deficiency", Master, pp.2007
- Xu L, "Clinical analysis of Jiawei Xiaoyao Pills in treating chronic fatigue syndrome", Nei Mong J Tradit Chinese Med, 2014(6), pp.12~13 (2014)
- Chen F, "Clinical Observation on Xiaoyao Pill Combined with Acupuncture and Massage for Chronic Fatigue Syndrome", Chinese J Ethnomedicine Ethnopharmacy, 25(15), pp.118~119 (2016)
- Li R, "Observation on the effect of massage combined with traditional Chinese medicine on chronic fatigue syndrome", J Pract Tradit chinese Med, 33(11), pp.1238~1239 (2017)
- Wei G, "Clinical Effect of Xiaoyao Pill Combined With Acupuncture and Massage in the Treatment of Chronic Fatigue Syndrome", China Contin Med Educ, 10(4), pp.136~138 (2018)
- Shi J, "Analysis of Clinical Curative Effect of Modified Xiaoyao San in Treatment of Chronic Fatigue Syndrome of Liver Depression and Spleen Deficiency", Syst Med, 4(1), pp.135~137 (2019)
- Pang Y, "Therapeutic Effect of Shengmai Powder Plus Modified Xiaoyao Powder for Treatment of Chronic Fatigue Syndrome", J Guangzhou Univ Tradit Chinese Med, 30(3), pp.316~319 (2013)
- Xu W, "Clinical Observation on Treatment of Chronic Fatigue Syndrome with Integrated Traditional Chinese and Western Medicine", Orient Diet-Therapy Heal Care, (8), pp.81~ (2015)
- Li H, "Clinical study of Liuwei Dihuang pill combined with Xiaoyao pill for chronic fatigue syndrome", J Hunan Univ Chinese Med, 29(6), pp.51~53 (2009)
- Yu B, "Gastroenterology", pp.305~ (2020), Koonja
- Kook YB, "Bangjaehak", pp.144~146 (1999), Yeongrimsa
- "Yearbook NHIS" (2013)[URL]
- Liu J, "Chinese herbal formula Xiao Yao San for treatment of depression : A systematic review of randomized controlled trials", Evidence-based Complement Altern Med, 2012, pp.931636~ (2012)
- Qin F, "Chinese herbal medicine modified xiaoyao san for functional dyspepsia : Meta-analysis of randomized controlled trials", J Gastroenterol Hepatol, 24(8), pp.1320~1325 (2009)
- Chen R, "Traditional chinese medicine for chronic fatigue syndrome", Evidence-based Complement Altern Med, 7(1), pp.3~10 (2010)