만성피로증후군의 한약치료에 대한 최신 임상 연구 동향 고찰
A Review of Herbal Medicine for the Treatment of Chronic Fatigue Syndrome
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective: This study aimed to systematically review and analyze the effects of herbal medicine treatment on chronic fatigue syndrome (CFS) after COVID-19. Methods: CFS-related studies published from January 1, 2020 to August 31, 2024 were screened from databases. A total of 15 randomized controlled trials (RCTs) were selected. A meta-analysis was conducted based on outcome measurements, such as the total effective rate (TER). Cochrane’s risk of bias 2 (RoB 2) was used for the qualitative evaluation of the papers. Results: All the studies were conducted in Asia, with 80% from China. The CFS diagnoses were mostly based on the Centers for Disease Control and Prevention (CDC) 1994 guidelines. The most common TKM diagnosis after COVID-19 was spleen deficiency, and the most frequently used outcome measurement was the TER. A meta-analysis showed statistically significant improvements of herbal treatments compared to Western medicine and conventional herbal medicine treatment in most studies. Conclusion: After COVID-19, herbal medicine treatment for CFS has focused on spleen deficiency syndrome, considering viral infection-induced immune system dysfunction as the primary cause. Newly researched herbal medicines have shown significant therapeutic effects. However, as this study has some limitations, improvements in the quality of research are required.
Abstract
Objective: This study aimed to systematically review and analyze the effects of herbal medicine treatment on chronic fatigue syndrome (CFS) after COVID-19. Methods: CFS-related studies published from January 1, 2020 to August 31, 2024 were screened from databases. A total of 15 randomized controlled trials (RCTs) were selected. A meta-analysis was conducted based on outcome measurements, such as the total effective rate (TER). Cochrane’s risk of bias 2 (RoB 2) was used for the qualitative evaluation of the papers. Results: All the studies were conducted in Asia, with 80% from China. The CFS diagnoses were mostly based on the Centers for Disease Control and Prevention (CDC) 1994 guidelines. The most common TKM diagnosis after COVID-19 was spleen deficiency, and the most frequently used outcome measurement was the TER. A meta-analysis showed statistically significant improvements of herbal treatments compared to Western medicine and conventional herbal medicine treatment in most studies. Conclusion: After COVID-19, herbal medicine treatment for CFS has focused on spleen deficiency syndrome, considering viral infection-induced immune system dysfunction as the primary cause. Newly researched herbal medicines have shown significant therapeutic effects. However, as this study has some limitations, improvements in the quality of research are required.
참고문헌 (40)
- Fukuda K, "The chronic fatigue syndrome : a comprehensive approach to its definition and study", Ann Intern Med, 121(12), pp.953~959 (1994)
- Noor N, "A comprehensive update of the current understanding of chronic fatigue syndrome", Anesth Pain Med, 11(3), pp.1~10 (2021)
- Kim JW, "Survey on Pattern Identification and Treatment of Chronic Fatigue in Korea Medicine", J Physiol & Pathol Korean Med, 32(2), pp.126~133 (2018)
- Chronic Fatigue Syndrome; Redefining an illness, "Beyond Myalgic Encephalomyelitis", pp.2015, Institute of Medicine
- Korean Medicine Clinical Practice Guideline for Chronic Fatigue, "Nam DH", NIKOM, 37~70 (2020)
- Lim EJ, "Systematic review and meta-analysis of the prevalence of chronic fatigue syndrome", myalgic encephalomyelitis(CFS, J Transl Med, pp.2020, 18(1)[DOI]
- Lim EJ, "Characteristics of Chronic Fatigue Syndrome(CFS) : based on Qualitative Content-Analysis of Patient Description", Korean Public Health Res, 46(1), pp.107~116 (2020)
- Bateman L, "Myalgic encephalomyelitis", chronic fatigue syndrome : essentials of diagnosis and management, 2021, pp.96(11), 2861~2878
- Bjørklund G, "Chronic fatigue syndrome(CFS) : Suggestions for a nutritional treatment in the therapeutic approach", Biomed Pharmacother, 109, pp.1000~1007 (2019)
- Werbach MR, "Nutritional strategies for treating chronic fatigue syndrome", Altern Med Rev, 5(2), pp.93~108 (2000)
- Cho JH, "Analytic Study for Syndrome-differentiation and Sasangconstitution in 72 Adults with Chronic Fatigue", J Int Korean Med, 28(4), pp.791~796 (2007)
- Wang CF, "Studies on the TCM syndrome types of CFS", Clinical J of Chin Med, 5(19), pp.7~9 (2013)
- Wood MS, "Impact of COVID-19 on myalgic encephalomyelitis", chronic fatigue syndrome-like illness prevalence : A cross-sectional survey, 2024, pp.19(9), 1~19
- Komaroff AL, "ME", CFS and Long COVID share similar symptoms and biological abnormalities : road map to the literature, 2023, pp.10, 1187163~
- Grabowska AD, "The importance of estimating prevalence of ME", CFS in future epidemiological studies of long COVID, 2023, pp.11, 1275827~
- National Academies of Sciences, Engineering, and Medicine, "A Long COVID Definition: A Chronic, Systemic Disease State with Profound Consequences", pp.28~36 (2024), The National Academies Press
- Santhouse AM, "Chronic fatigue syndrome", BMJ, 340, pp.c738~ (2010)
- BØhn SH, "Chronic fatigue and associated factors among long-term survivors of cancers in young adulthood", Acta Oncol, 58(5), pp.753~762 (2019)
- NECA’s guidance for assessing tools of risk of bias, "Kim SY", National Evidence based Healthcare Collaborating Agency, 76~132 (2021)
- NECA’s guidance for undertaking systematic reviews and meta-analyses for intervention, "Kim SY", National Evidence based Healthcare Collaborating Agency, 129~201 (2011)
- Shin S, "Effectiveness a herbal medicine(Sipjeondaebo-tang)on adults with chronic fatigue syndrome : A randomized, double-blind, placebo-controlled trial", Integr Med Res, 10(2), pp.1~8 (2021)
- Pan SH, "Clinical Study on Sijunzi Decoction for Chronic Fatigue Syndrome of Spleen Deficiency Type", J New Chin Med, 56(6), pp.23~28 (2024)
- Li Z, "Study on the effect of Shengxian decoction on infrared characteristics of xu li and du meridian in patients with chronic fatigue syndrome", J Hunan Normal Univ(Med Sci), 20(4), pp.134~147 (2023)
- Zang DW, "Clinical efficacy of Heirong capsule in the treatment of chronic fatigue syndrome", J of Jilin Med Univ, 44(5), pp.1253~1256 (2023)
- 盛成和, "柴胡桂枝汤颗粒剂治疗肝郁脾虚型慢性疲劳综合征的临床效果", 临床合理用药杂志, 13(35), pp.60~61 (2020)
- Zhou CL, "Curative effect of Xinshen’an Capsule on chronic fatigue syndrome and its influences on peripheral blood NK cells activity and T lymphocyte subsets", J Hunan Normal Univ(Med Sci), 19(3), pp.53~56 (2022)
- Chen ZN, "Clinical observation of Xiaoyao powder in treating 33 cases of chronic fatigue syndrome", Clinical J of Chin Med, 13(9), pp.140~141 (2021)
- Dong LL, "Clinical observation of Qingshu Yiqi decoction in treating chronic fatigue syndrome with dampness-heat of spleen deficiency", Chin's Naturopathy, 28(20), pp.72~74 (2020)
- Li XH, "Clinical Effect of Guashen Decoction on Chr onic Fatigue Syndrome of Deficiency of Qi and Yin", Clinical Journal of Traditional Chinese Medicine, 34(7), pp.1331~1335 (2022)
- Wu YL, "Study on the Clinical Effect of Dispelling Dampness-Replenishing Qi-Nourishing Yin Step Therapy in the Treatment of Chronic Fatigue Syndrome", Guangming J of Chin Med, 37(11), pp.1894~1898 (2022)
- Liu J, "The clinical observation of Chaihu Guizhi decoction in treating chronic fatigue syndrome and the influence of emotional factors", World Journal of integrated Traditional and Western Med, 16(10), pp.1908~1911 (2021)
- Choi JY, "Efficacy and safety of herbal medicine Gongjin-Dan and Ssanghwa-Tang in patients with chronic fatigue : A randomized, double-blind, placebo-controlled, clinical trial", Integr Med Res, 13(1), pp.1~11 (2024)
- Dai L, "Sijunzi decoction, a classical Chinese herbal formula, improves fatigue symptoms with changes in gut microbiota in chronic fatigue syndrome : A randomized, double-blind, placebocontrolled, multi-center clinical trial", Phytomedicine, 129, pp.155636~ (2024)
- Kan J, "A botanical product containing Cistanche and Ginkgo extracts potentially improves chronic fatigue syndrome symptoms in adults : a randomized, double-blind, and placebo-controlled study", Front Nutr, 8, pp.658630~ (2021)
- Sung WS, "Efficacy of Korean red ginseng(Panax ginseng)for middle-aged and moderate level of chronic fatigue patients : A randomized, double-blind, placebo-controlled trial", Complement Ther Med, 48, pp.102246~ (2020)
- 田代华, "黄帝内经素问", pp.78~ (2005), People's Medical Publishing House
- 李东垣, "脾胃论", pp.56~ (2005), People's Medical Publishing House
- Lee KE, "Review on Herbal Medicine Treatment for Late Complications of COVID-19Patients", J Int Korean Med, 42(1), pp.53~66 (2021)
- Joli J, "Post-COVID-19fatigue : A systematic review", Front Psychiatry, 13, pp.947973~ (2022)
- Chen XY, "Traditional, complementary and integrative medicine for fatigue post COVID-19infection : A systematic review of randomized controlled trials", Integr Med Res, 13(2), pp.1~12 (2024)