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동충하초의 균사 및 배양액에 의한 면역 활성 비교

Anti-Immunomodulating Activities in Mycelial Filtrates and Culture Broth of Cordyceps ochraceostromat

남소현|정신교|이상한|박철홍|남성희|이광길|여주홍|허진철|윤철식|손민식
한국식품저장유통학회 (The Korean Society of Food Preservation)|2009.04|Food Science and Preservation|제16권 제2호|pp. 253-258

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참고문헌

주제분류식품과학

초록

Abstract

This study investigated the effects of mycelium and culture supernatant of Cordyceps ochraceostromat(Co) on air way hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of atopy and asthma. After ConA(+/-) activation of mouse primary spleen cells, decreased IL-4 and IL-13 cytokine production were seen in the presence of Co mycelium extracts and culture supernatant. The asthma model involved mice sensitized to ovalbumin by i.p. injection treatment; Co mycelium extract was also injected. The atopy model was the dinitrofenylbenzene-treated mouse ear. Ear thicken ing induced by DNFB was decreased by Co mycelium extract, and the extract also inhibited lung cell infiltration in ovalbumin-induced asthmatic mice. The results thus indicated that the Co mycelial extract reduced the undesirable immune responses seen in asthma and atopy.

참고문헌 (22)

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