Prevalence of group B streptococcus colonization in pregnant women in a tertiary care center in Korea
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Objective The purpose of this study was to evaluate the group B streptococcus (GBS) colonization rate in pregnant Koreanwomen using selective culture media for GBS and to identify obstetrical complications and GBS-induced early-onsetneonatal sepsis. Methods We evaluated 1,014 pregnant women who delivered at Busan Paik Hospital between January 2015 and December2016. GBS colonization was assessed using chromID Strepto B agar. We evaluated GBS colonization in pregnantwomen, as well as the obstetrical complication and GBS-induced neonatal sepsis rates. Results The total GBS colonization rate was 11.6% (117/1,014). No significant increase was observed in the rate of pregnancyrelatedcomplications between the GBS-positive and the GBS-negative groups. Among the 134 neonates born tocolonized mothers, early neonatal sepsis was reported in 2 neonates (1.5%); however, these were cases of non-GBSinducedsepsis. Conclusion The GBS colonization rate (using selective culture media) in this study involving pregnant Korean women showed ahigher colonization rate than that previously reported in Korea. Therefore, based on this study, we recommend GBSscreening and the administration of intrapartum antibiotic prophylaxis in pregnant Korean women.
Abstract
Objective The purpose of this study was to evaluate the group B streptococcus (GBS) colonization rate in pregnant Koreanwomen using selective culture media for GBS and to identify obstetrical complications and GBS-induced early-onsetneonatal sepsis. Methods We evaluated 1,014 pregnant women who delivered at Busan Paik Hospital between January 2015 and December2016. GBS colonization was assessed using chromID Strepto B agar. We evaluated GBS colonization in pregnantwomen, as well as the obstetrical complication and GBS-induced neonatal sepsis rates. Results The total GBS colonization rate was 11.6% (117/1,014). No significant increase was observed in the rate of pregnancyrelatedcomplications between the GBS-positive and the GBS-negative groups. Among the 134 neonates born tocolonized mothers, early neonatal sepsis was reported in 2 neonates (1.5%); however, these were cases of non-GBSinducedsepsis. Conclusion The GBS colonization rate (using selective culture media) in this study involving pregnant Korean women showed ahigher colonization rate than that previously reported in Korea. Therefore, based on this study, we recommend GBSscreening and the administration of intrapartum antibiotic prophylaxis in pregnant Korean women.
참고문헌 (28)
- Dillon HC Jr, "Anorectal and vaginal carriage of group B streptococci during pregnancy", J Infect Dis, 145, pp.794~799 (1982)[DOI]
- Edwards MS, "Mandell, Douglas, and Bennett's principles and practice of infectious diseases", pp.2015, Elsevier
- Cunningham FG, "Williams obstetrics", pp.2014, McGraw-Hill Education
- Schuchat A, "Risk factors and opportunities for prevention of early-onset neonatal sepsis: a multicenter case-control study", Pediatrics, 105, pp.21~26 (2000)[DOI]
- Edwards MS, "Remington and Klein's infectious diseases of the fetus and newborn infant", pp.2016, Elsevier
- 김경아, "신생아 패혈증의 원인균에 대한 전국 조사", Clinical and Experimental Pediatrics, 45(1), pp.55~63 (2002), 대한소아청소년과학회
- 이준호, "Etiology of Invasive Bacterial Infections in Immunocompetent Children in Korea (1996-2005): A Retrospective Multicenter Study", Journal of Korean Medical Science, 26(2), pp.174~183 (2011), 대한의학회
- Regan JA, "The epidemiology of group B streptococcal colonization in pregnancy. Vaginal Infections and Prematurity Study Group", Obstet Gynecol, 77, pp.604~610 (1991)
- Yancey MK, "The accuracy of late antenatal screening cultures in predicting genital group B streptococcal colonization at delivery", Obstet Gynecol, 88, pp.811~815 (1996)[DOI]
- Campbell JR, "Group B streptococcal colonization and serotype-specific immunity in pregnant women at delivery", Obstet Gynecol, 96, pp.498~503 (2000)
- 김태형, "LIM Broth 배지를 이용한 임산부에서의 B군 연쇄구균 감염에 대한 연구", Clinical and Experimental Pediatrics, 47(10), pp.1072~1075 (2004), 대한소아청소년과학회
- Park LS, "A study of group B streptococcal infection in Korean pregnant women", Korean J Obstet Gynecol, 42, pp.2038~2042 (1999)
- 최길웅, "임신부에서 group B streptococci 감염의 임상적 의의", Obstetrics & Gynecology Science, 45(5), pp.811~815 (2002), 대한산부인과학회
- 김민우, "우리나라 임신부에서의 B군 사슬알균의집락화에 대한 연구", Obstetrics & Gynecology Science, 49(2), pp.337~344 (2006), 대한산부인과학회
- 어영, "임신부의 Group B Streptococci 보균율, 혈청형 및 Macrolide-Lincosamide-StreptograminB 내성형의 분포", Annals of Clinical Microbiology, 12(4), pp.174~179 (2009), 대한임상미생물학회
- 오지은, "임신부에서 분리된 B군 연구균의 중합효소연쇄반응과 염기서열분석을 통한 혈청형 분석", Pediatric Infection and Vaccine, 16(1), pp.47~53 (2009), 대한소아감염학회
- Hong JS, "Genital group B Streptococcus carrier rate and serotype distribution in Korean pregnant women: implications for group B streptococcal disease in Korean neonates", J Perinat Med, 38, pp.373~377 (2010)
- Poisson DM, "Evaluation of CHROMagar StrepB: a new chromogenic agar medium for aerobic detection of group B streptococci in perinatal samples", J Microbiol Methods, 82, pp.238~242 (2010)[DOI]
- Verani JR, "Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010", MMWR Recomm Rep, 59, pp.1~36 (2010)
- Cunningham FG, "Williams obstetrics", pp.2014, McGraw-Hill Education
- Nizet V, "Remington and Klein's infectious diseases of the fetus and newborn infant", pp.2016, Elsevier
- Morita T, "Evaluation of chromID strepto B as a screening media for Streptococcus agalactiae", BMC Infect Dis, 14, pp.46~ (2014)[DOI]
- Eun Ju Kim, "Risk Factors for Group B Streptococcus Colonization Among Pregnant Women in Korea", Epidemiology and Health, 33, pp.1~7 (2011), 한국역학회
- Regan JA, "Premature rupture of membranes, preterm delivery, and group B streptococcal colonization of mothers", Am J Obstet Gynecol, 141, pp.184~186 (1981)[DOI]
- McDonald H, "Group B streptococcal colonization and preterm labour", Aust N Z J Obstet Gynaecol, 29, pp.291~293 (1989)[DOI]
- Feikin DR, "Association between colonization with group B streptococci during pregnancy and preterm delivery among Danish women", Am J Obstet Gynecol, 184, pp.427~433 (2001)[DOI]
- Kubota T, "Relationship between maternal group B streptococcal colonization and pregnancy outcome", Obstet Gynecol, 92, pp.926~930 (1998)
- Valkenburg-van den Berg AW, "Association between colonization with Group B Streptococcus and preterm delivery: a systematic review", Acta Obstet Gynecol Scand, 88, pp.958~967 (2009)[DOI]