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연관Glutathione S-Transferase (GST) 유전자 다형성과 항정신병약물로 유발된 하지불안증후군의 연관 연구

Association between Antipsychotic-Induced Restless Legs Syndrome and Glutathione S-Transferase Gst-M1, Gst-T1 and Gst-P1 Gene Polymorphisms

박영민|김린|강승걸|이헌정
대한수면의학회 (Korean Academy of Sleep Medicine)|2015.07|수면정신생리 (Sleep Medicine and Psychophysiology)|제22권 제1호|pp. 25-29|DOI http://dx.doi.org/10.14401/KASMED.2015.22.1.25

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조현병Schizophrenia하지불안증후군Restless legs syndrome유전자다형성항정신병약물AntipsychoticsPolymorphismGlutathione S-transferase 유전자Glutathione S-transferase genes
주제분류정신과학

초록

목 적：하지불안증후군(restless legs syndrome ; RLS)의 병인은 아직 불명확하지만, 유전적 질환으로 알려져 있다. 산화스트레스는 RLS, 지연성운동장애, 파킨슨병, 뚜렛장애 등의 운동장애에서 주요한 원인 중의 하나로 생각되고 있다. 본 연구에서는 조현병환자에서 항정신병약물에 의해 유발된 RLS 증상이 산화손상의 해독효소인 glutathione S-transferase (GST) 유전자의 다형성과 연관이 있는지를 밝히고자 하였다. 방 법：International Restless Legs Syndrome Study Group의 진단기준으로 190명의 한국인 조현병 환자들을 대상으로 RLS에 대해서 평가하였다. 유전자형분석은 중합효소연쇄반응기법을 사용하여 GST-M1, GST-T1, GST-P1의 세 가지 단일염기다형성(single nucleotide polymorphism, SNP)에 대해서 시행되었다. 결 과：RLS 증상군 96명과 무증상군 94명으로 피험자들을 분류하였다. GST-M1 (χ2 = 3.56, p = 0.059), GST-T1 (χ2 = 0.51, p = 0.476), GST-P1 (χ2 = 0.57, p = 0.821)의 유전자형 빈도에 두 군간에 통계적으로 유의한 차이가 없었다. 유전자형에 따른 RLS 척도의 점수도 GST-M1 (t = -1.54, p = 0.125), GST-T1 (t = -0.02, p = 0.985), GST-P1 (F = 0.58, p = 0.560)의 세 가지 SNP에서 통계적으로 유의한 차이를 보이지 않았다. 결 론：본 연구의 결과 GST 유전자 다형성이 항정신병약물로 유발된 RLS 증상 발생의 민감성을 증가시킨다는 증거는 발견할 수 없었다. 산화손상과 관련된 다른 후보 유전자들에 대한 향후 연구가 필요할 것으로 사료된다.

Abstract

Objectives: The pathophysiology of restless legs syndrome (RLS) has not been fully elucidated. Oxidative stress might play a role in the development of RLS and other antipsychotic-induced side effects such as tardive dyskinesia. In the present study, we investigated whether the glutathione S-transferase (GST) gene polymorphisms are associated with antipsychotic-induced RLS in schizophrenia. Methods: We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. The GST-M1, GST-T1 and GST-P1 loci were analyzed using PCR-based methods. Results: We divided the subjects into 2 groups: those with RLS symptoms (n = 96) and those without RLS symptoms (n = 94). There were no significant differences in the distributions of the GST-M1 genotypes (χ2 = 3.56, p = 0.059), GST-T1 (χ2 = 0.51, p = 0.476) and GST-P1 (χ2 = 0.57, p = 0.821) between the 2 groups. Comparison of the RLS score among genotypes of the GST-M1 (t = –1.54, p = 0.125), GST-T1 (t = –0.02, p = 0.985) and GST-P1 (F = 0.58, p = 0.560) revealed no significant difference. Conclusion: These data suggest that GST gene polymorphisms do not confer increased susceptibility to RLS symptoms in schizophrenic patients. Future studies are necessary to evaluate the possible influences of other candidate genes involved in the reactive oxygen species system.

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