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항정신병제의 복용은 하지불안증후군의 위험 요소인가?

Is Antipsychotic Intake a Risk Factor for the Restless Legs Syndrome?

차정인|정희연|조진환|홍윤호|남현우
대한신경과학회 (Korean Neurological Association)|2009.02|대한신경과학회지 (Journal of the Korean Neurological Association)|제27권 제1호|pp. 49-53

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참고문헌

키워드

SchizophreniaAntipsychoticDopaminergic systemRestless-legs syndrome
주제분류신경과학

초록

Background: Restless-legs syndrome (RLS) is known to be caused by dopaminergic hypofunction in the brain. We investigated whether antipsychotics that act as antidopaminergics increase the risk of RLS. Methods: We prospectively recruited 72 schizophrenic patients who had been medicated with antipsychotic drugs in a psychiatry clinic. We evaluated RLS diagnostic criteria and basic sleep habits using the Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index by face-to-face interviews using a structured questionnaire. We also applied the Unified Parkinson’s Disease Rating Scale to evaluate extrapyramidal symptoms. Results: Three of the 72 patients (4.2%) met RLS criteria, which is similar to the previously reported RLS incidence among the general population in Korea. Conclusions: There is no evidence that antipsychotics increase the risk of RLS. We believe that the mild antidopaminergic effect of antipsychotics does not overwhelm their prominent antipsychotic effect.

Abstract

Background: Restless-legs syndrome (RLS) is known to be caused by dopaminergic hypofunction in the brain. We investigated whether antipsychotics that act as antidopaminergics increase the risk of RLS. Methods: We prospectively recruited 72 schizophrenic patients who had been medicated with antipsychotic drugs in a psychiatry clinic. We evaluated RLS diagnostic criteria and basic sleep habits using the Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index by face-to-face interviews using a structured questionnaire. We also applied the Unified Parkinson’s Disease Rating Scale to evaluate extrapyramidal symptoms. Results: Three of the 72 patients (4.2%) met RLS criteria, which is similar to the previously reported RLS incidence among the general population in Korea. Conclusions: There is no evidence that antipsychotics increase the risk of RLS. We believe that the mild antidopaminergic effect of antipsychotics does not overwhelm their prominent antipsychotic effect.

참고문헌 (36)

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관련 논문AI추천

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