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중의학 데이터베이스 (CAJ)를 이용한 급성백혈병의 한약치료에 대한 임상 연구 동향

Review of Clinical Studies for Herbal Medicine Treatment on Acute Leukemia - Focusing on Studies from the China Academic Journal (CAJ) -

김기봉|천진홍|장진우|박범찬|김정은
대한한방소아과학회 (The Association of Pediatrics of Korean Medicine)|2021.02|대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)|제35권 제1호|pp. 48-62

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참고문헌

키워드

Randomized Controlled TrialChildHerbal medicineReviewAcute leukemia
주제분류한의학

초록

Objectives The purpose of this study is to obtain knowledge from clinical studies conducted in China to examine the effectiveness of herb medicine in childhood acute leukemia. Methods: We searched the randomized controlled trials (RCTs) with herbal medicine treatment on childhood acute leukemia from the ‘CAJ’, Chinese Academic Journal from China National Knowledge Infrastructure (CNKI). And then, demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study. Result: 10 RCT studies were selected and analyzed. The control group were given western medicine therapy, the treatment group was given herbal medicine on the basis of the control group. The most commonly used herbal medicine were 淸熱解毒藥, 補氣藥, 補陰藥, 活血祛瘀藥 in ‘boosting vital force and driving out evil spirit (扶正祛邪)’ way to ‘relieve heat (熱毒)’ and ‘assist the vital force (正氣)’. In the treatment group, complete remission was significantly higher than control group and the decrease in TCM syndrome scores also showed significant effects. Adverse events were significantly lower in the treatment group. Conclusions: Herbal medicine treatment on childhood acute leukemia can be suggested as a new treatment for children who have less response to the conventional therapy, and can supplement the limitations of the western medicine by increasing complete remission and reducing adverse events.

Abstract

Objectives The purpose of this study is to obtain knowledge from clinical studies conducted in China to examine the effectiveness of herb medicine in childhood acute leukemia. Methods: We searched the randomized controlled trials (RCTs) with herbal medicine treatment on childhood acute leukemia from the ‘CAJ’, Chinese Academic Journal from China National Knowledge Infrastructure (CNKI). And then, demographic data, duration of illness, intervention, treatment period, outcome, adverse events, and composition of herbal medicine were analyzed for this study. Result: 10 RCT studies were selected and analyzed. The control group were given western medicine therapy, the treatment group was given herbal medicine on the basis of the control group. The most commonly used herbal medicine were 淸熱解毒藥, 補氣藥, 補陰藥, 活血祛瘀藥 in ‘boosting vital force and driving out evil spirit (扶正祛邪)’ way to ‘relieve heat (熱毒)’ and ‘assist the vital force (正氣)’. In the treatment group, complete remission was significantly higher than control group and the decrease in TCM syndrome scores also showed significant effects. Adverse events were significantly lower in the treatment group. Conclusions: Herbal medicine treatment on childhood acute leukemia can be suggested as a new treatment for children who have less response to the conventional therapy, and can supplement the limitations of the western medicine by increasing complete remission and reducing adverse events.

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