다발경화증과 시신경척수염범주질환의 감별진단
Differential Diagnosis between Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
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참고문헌
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초록
Until recently, neuromyelitis optica (NMO) was considered to be a clinical variant of multiple sclerosis (MS). The discovery of disease-specific anti-aquaporin-4 antibody has facilitated the differentiation of NMO from MS and led to the recognition of a broader phenotypic spectrum now referred to as neuromyelitis optica spectrum disorder (NMOSD). However, distinguishing NMOSD from MS remains challenging, as a subgroup of NMOSD patients are found to be seronegative. The ability to differentiate between NMOSD and MS is critical because these conditions have distinct treatments and prognoses, and the disease-modifying treatment for MS can actually aggravate NMOSD. This review focuses on clinically relevant guidance for diagnosing and differentiating between NMOSD and MS.
Abstract
Until recently, neuromyelitis optica (NMO) was considered to be a clinical variant of multiple sclerosis (MS). The discovery of disease-specific anti-aquaporin-4 antibody has facilitated the differentiation of NMO from MS and led to the recognition of a broader phenotypic spectrum now referred to as neuromyelitis optica spectrum disorder (NMOSD). However, distinguishing NMOSD from MS remains challenging, as a subgroup of NMOSD patients are found to be seronegative. The ability to differentiate between NMOSD and MS is critical because these conditions have distinct treatments and prognoses, and the disease-modifying treatment for MS can actually aggravate NMOSD. This review focuses on clinically relevant guidance for diagnosing and differentiating between NMOSD and MS.
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