헬리코박터 항체양성률과 급성 허혈성 뇌졸중과의 관계

Abstract

Background: Helicobacter pylori (H. pylori) have been associated pathogenetically with coronary atherosclerosis. Although stroke is pathogenetically related to coronary heart disease, data on relationship between chronic infection and acute ischemic stroke in Korea are lacking. Therefore, we verified the relation of chronic H. pylori infection and risk of acute ischemic stroke, also chronic H. pylori infection and stroke subtypes. Methods: From July 2004 to May 2005, 228 patients with acute ischemic stroke and 64 control subjects were enrolled in this study. All patients underwent diagnostic work-up including brain MRI, mognetic resonance (MR) anogiograhpy, risk factor evaluation and subtype classification according to the Trial of Org 10172 in the Acute Stroke Treatment (TOAST) criteria. IgG antibodies to H. pylori was measured by enzyme linked immunosorbent assay technique. Results: There was tendency that H. pylori seropositivity in stroke patients (74%) was higher than that of controls (64%). Chronic H. pylori infection was associated with a higher risk of acute ischemic stroke patients under 65 years (adjusted odds ratio: 2.608; 95% CI: 1.151-5.908) and small vessel disease (SVD)(adjusted odds ratio: 2.762; 95% CI: 1.257-6.067). Conclusion: This study shows that chronic H. pylori infection is associated with acute ischemic stroke patients under 65 years and SVD. Further studies are required to reveal whether chronic H. pylori infection is an independent risk factor for acute ischemic stroke. (Korean J Stroke 2007;9:120-123)