만성 헬리코박타 감염과 허혈성 뇌졸중과의 관계-예비 연구
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Background and Objectives: Although there is evidence that chronic Helicobacter pylori (H.pylori) infection may be a risk factor for ischemic cerebrovascular disease, the association remains controversial. To determine whether H.pylori infection is a risk factor for ischemic stroke, we compared the H.pylori IgG antibody seropositivity between patients and controls. We also examined the relationship of H.pylori IgG seropositivity and other conventional risk factors. Methods: A total of 142 acute ischemic stroke patients and 80 controls with non-vascular neurological disease were studied. Stroke subtypes were categorized based on the pathogenesis subtype. Patients’ sera were analyzed for the titer of H.pylori IgG antibody by ELISA. Results: There was no apparent association between H. pylori seropositivity and ischemic stroke. There was no difference in seropositivity among the ischemic stroke subtypes. Only smoking was related to high H.pylori seropositivity among conventional risk factors. Conclusion: In this study, we didn’t find the significant relationship between chronic H.pylori infection and the ischemic stroke. Further prospective study is required.
Abstract
Background and Objectives: Although there is evidence that chronic Helicobacter pylori (H.pylori) infection may be a risk factor for ischemic cerebrovascular disease, the association remains controversial. To determine whether H.pylori infection is a risk factor for ischemic stroke, we compared the H.pylori IgG antibody seropositivity between patients and controls. We also examined the relationship of H.pylori IgG seropositivity and other conventional risk factors. Methods: A total of 142 acute ischemic stroke patients and 80 controls with non-vascular neurological disease were studied. Stroke subtypes were categorized based on the pathogenesis subtype. Patients’ sera were analyzed for the titer of H.pylori IgG antibody by ELISA. Results: There was no apparent association between H. pylori seropositivity and ischemic stroke. There was no difference in seropositivity among the ischemic stroke subtypes. Only smoking was related to high H.pylori seropositivity among conventional risk factors. Conclusion: In this study, we didn’t find the significant relationship between chronic H.pylori infection and the ischemic stroke. Further prospective study is required.