Depression, Rather Than Cancer-Related Fatigue or Insomnia, Decreased the Quality of Life of Cancer Patients
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Purpose Cancer-related fatigue is a common and distressing symptom that occurs during cancer treatment. This study aimed to find factors that are related to cancer-related fatigue, and its effect on patients’ quality of life. Materials and Methods This study included 159 patients who completed questionnaires and interviews during their initial examination at the sleep clinic for cancer patients, Asan Medical Center, between December 2018 and January 2020. Their medical reports were reviewed retrospectively. Questionnaire data about depression, anxiety, insomnia, fear of disease progression, and dysfunctional beliefs about sleep, pain, and quality of life, were reviewed. Additionally, patient sleep structure data were analyzed. Results Factors such as depression (p < 0.001), anxiety (p < 0.001), fear of cancer progression (p < 0.001), fatigue (p=0.027), and time in bed during 24 hours (p=0.037) were significant expecting variables for low quality of life from logistic regression analysis. In pathway analysis, depression (p < 0.001), not cancer-related fatigue (p=0.537), act as a direct risk factor on quality of life. And also, depression was an overall risk factor for insomnia, fatigue, and daily activity of cancer patients. Conclusion Cancer-related fatigue did not show significant effect on patient’s quality of life in this study. However, the result of pathway analysis highlights the importance of assessing depression in the process of cancer treatment and providing appropriate interventions.
Abstract
Purpose Cancer-related fatigue is a common and distressing symptom that occurs during cancer treatment. This study aimed to find factors that are related to cancer-related fatigue, and its effect on patients’ quality of life. Materials and Methods This study included 159 patients who completed questionnaires and interviews during their initial examination at the sleep clinic for cancer patients, Asan Medical Center, between December 2018 and January 2020. Their medical reports were reviewed retrospectively. Questionnaire data about depression, anxiety, insomnia, fear of disease progression, and dysfunctional beliefs about sleep, pain, and quality of life, were reviewed. Additionally, patient sleep structure data were analyzed. Results Factors such as depression (p < 0.001), anxiety (p < 0.001), fear of cancer progression (p < 0.001), fatigue (p=0.027), and time in bed during 24 hours (p=0.037) were significant expecting variables for low quality of life from logistic regression analysis. In pathway analysis, depression (p < 0.001), not cancer-related fatigue (p=0.537), act as a direct risk factor on quality of life. And also, depression was an overall risk factor for insomnia, fatigue, and daily activity of cancer patients. Conclusion Cancer-related fatigue did not show significant effect on patient’s quality of life in this study. However, the result of pathway analysis highlights the importance of assessing depression in the process of cancer treatment and providing appropriate interventions.
참고문헌 (29)
- Lawrence DP, "Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients", J Natl Cancer Inst Monogr, (32), pp.40~50 (2004)
- Mock V, "NCCN practice guidelines for cancer-related fatigue", Oncology(Williston Park), 14, pp.151~161 (2000)
- Bower JE, "Cancer-related fatigue : mechanisms, risk factors, and treatments", Nat Rev Clin Oncol, 11, pp.597~609 (2014)
- Jacobsen PB, "Fatigue in women receiving adjuvant chemotherapy for breast cancer : characteristics, course, and correlates", J Pain Symptom Manage, 18, pp.233~242 (1999)
- Hickok JT, "Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer", Cancer, 104, pp.1772~1778 (2005)
- Cella D, "Cancer related fatigue : prevalence of proposed diagnostic criteria in a United States sample of cancer survivors", J Clin Oncol, 19, pp.3385~3391 (2001)
- Bower JE, "Fatigue in breast cancer survivors : occurrence, correlates, and impact on quality of life", J Clin Oncol, 18, pp.743~753 (2000)
- Curt GA, "Impact of cancer-related fatigue on the lives of patients : new findings from the Fatigue Coalition", Oncologist, 5, pp.353~360 (2000)
- Mitchell SA, "Cancer-related fatigue : state of the science", PM R, 2, pp.364~383 (2010)
- Barsevick A, "I’m so tired : biological and genetic mechanisms of cancer-related fatigue", Qual Life Res, 19, pp.1419~1427 (2010)
- Fiorentino L, "The symptom cluster of sleep, fatigue and depressive symptoms in breast cancer patients : severity of the problem and treatment options", Drug Discov Today Dis Models, 8, pp.167~173 (2011)
- Kroenke K, "The PHQ-9 : validity of a brief depression severity measure", J Gen Intern Med, 16, pp.606~613 (2001)
- Spielberger CD, "The use of psychological testing for treatment planning and outcome assessment", pp.292~321 (1994), Lawrence Erlbaum Associates, Inc
- Bastien CH, "Validation of the Insomnia Severity Index as an outcome measure for insomnia research", Sleep Med, 2, pp.297~307 (2001)
- Chung S, "Assessment of cancer-related dysfunctional beliefs about sleep for evaluating sleep disturbance in cancer patients", Sleep Med Res, 8, pp.98~101 (2017)
- Herschbach P, "Fear of progression in chronic diseases : psychometric properties of the Fear of Progression Questionnaire", J Psychosom Res, 58, pp.505~511 (2005)
- Shim EJ, "Increased fear of progression in cancer patients with recurrence", Gen Hosp Psychiatry, 32, pp.169~175 (2010)
- Mehnert A, "Fear of progression in breast cancer patients : validation of the short form of the Fear of Progression Questionnaire(FoP-Q-SF)", Z Psychosom Med Psychother, 52, pp.274~288 (2006)
- Staehr JK, "Well-being measures in primary health care: the DepCare Project", pp.E60246~ (1998), World Health Organization
- Minnock P, "Fatigue is a reliable, sensitive and unique outcome measure in rheumatoid arthritis", Rheumatology(Oxford), 48, pp.1533~1536 (2009)
- Temel JS, "Feasibility and validity of a one-item fatigue screen in a thoracic oncology clinic", J Thorac Oncol, 1, pp.454~459 (2006)
- Bijur PE, "Validation of a verbally administered numerical rating scale of acute pain for use in the emergency department", Acad Emerg Med, 10, pp.390~392 (2003)
- Insoo Kim, "Dysfunctional Beliefs about Sleep in Cancer Patients Can Mediate the Effect of Fear of Progression on Insomnia", sleep medicine research, 10(2), pp.83~89 (2019), 대한수면학회[DOI]
- Parker G, "Psychomotor change as a feature of depressive disorders : an historical overview", Aust N Z J Psychiatry, 26, pp.146~155 (1992)
- Stone P, "Cancer-related fatigue: inevitable, unimportant and untreatable? Results of a multi-centre patient survey", Ann Oncol, 11, pp.971~975 (2000)
- Difrancesco S, "Sleep, circadian rhythm, and physical activity patterns in depressive and anxiety disorders : a 2-week ambulatory assessment study", Depress Anxiety, 36, pp.975~986 (2019)
- Choi S, "Effects of symptom clusters and depression on the quality of life in patients with advanced lung cancer", Eur J Cancer Care(Engl), 27, pp.e12508~ (2018)
- Omran S, "Symptom severity, anxiety, depression, self-efficacy and quality of life in patients with cancer", Asian Pac J Cancer Prev, 19, pp.365~374 (2018)
- Redeker NS, "Insomnia, fatigue, anxiety, depression, and quality of life of cancer patients undergoing chemotherapy", Sch Inq Nurs Pract, 14, pp.275~290 (2000)