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Myocilin as a Potential Factor for the Fast Type Change in the Muscle Isoform Composition: A Mini Review

지현석|최윤숙
대한운동학회 (Korean Acadaemy of Kinesiology)|2023.01|아시아 운동학 학술지 (The Asian Journal of Kinesiology)|제25권 제1호|pp. 19-26

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키워드

Skeletal MuscleFast Type ⅡMhc(Myosin Heavy Chain)Myoc(Myocilin)Slow TypeⅠ

초록

BACKGROUND Various factors-based properties of the skeletal muscle are determined by mechanical stress, chemical stimuli, neuromuscular stimuli, different protein isoforms etc. The properties of the muscle are formed in the process of the balance between anabolism and catabolism. Especially, the anabolism on the way of the cell proliferation to its differentiation is accompanied by various controlling signal pathways. OBJECTIVE The purpose of this study focused on the mTOR/S6K system, Myosin, and Myocilin among these signaling pathways, especially on previously reported studies on the contribution of Myocilin to the skeletal muscle fiber type transformation. METHODS To identify the molecular pathways related to muscle development, the KEGG Mapper was used to present the mTOR-related signaling system that has not been identified so far. RESULTS Consequently, it suggests that it affects the myogenic process, through the path of PI3K->AKT- >MEF2->MyoC->mTOR->p70S6K->S6. CONCLUSIONS It also suggests that Myocilin serves as a potential effector to control skeletal muscle cell type. Furthermore, more detailed study on the potential target-oriented (to the fast or slow fiber type change) role of Myocilin for enhancing the health state by adjusted exercise programs developed by its optimal type, intensity, frequency, and time is awaited.

Abstract

BACKGROUND Various factors-based properties of the skeletal muscle are determined by mechanical stress, chemical stimuli, neuromuscular stimuli, different protein isoforms etc. The properties of the muscle are formed in the process of the balance between anabolism and catabolism. Especially, the anabolism on the way of the cell proliferation to its differentiation is accompanied by various controlling signal pathways. OBJECTIVE The purpose of this study focused on the mTOR/S6K system, Myosin, and Myocilin among these signaling pathways, especially on previously reported studies on the contribution of Myocilin to the skeletal muscle fiber type transformation. METHODS To identify the molecular pathways related to muscle development, the KEGG Mapper was used to present the mTOR-related signaling system that has not been identified so far. RESULTS Consequently, it suggests that it affects the myogenic process, through the path of PI3K->AKT- >MEF2->MyoC->mTOR->p70S6K->S6. CONCLUSIONS It also suggests that Myocilin serves as a potential effector to control skeletal muscle cell type. Furthermore, more detailed study on the potential target-oriented (to the fast or slow fiber type change) role of Myocilin for enhancing the health state by adjusted exercise programs developed by its optimal type, intensity, frequency, and time is awaited.

참고문헌 (42)

  1. Alberts, "Molecular Biology of The Cell", pp.1232~1235 (2014)
  2. Tomarev SI, "Characterization of the Mouse Myoc", Tigr Gene, 1998, pp.245, 887~893
  3. Fingert JH, "Characterization and Comparison of the Human and Mouse GLC1A Glaucoma Genes", Genome Res, 8(4), pp.377~384 (1998)
  4. Dumont NA, "Satellite Cells and Skeletal Muscle Regeneration", Comprhysiol, pp.1027~1059 (2015)
  5. Chal J, "Making muscle: Skeletal myogenesis in vivo and in vitro", Development, 144(12), pp.2104~2122 (2017)
  6. Wagers AJ, "Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis", Cell, 122(5), pp.659~667 (2005)
  7. Zhang M, "During Secondary Myotube Formation, Primary Myotubes Preferentially Absorb New Nuclei at Their Ends", Dev Dyn, 204(2), pp.168~177 (1995)
  8. Kunihiro Sakum, "Muscle Cell and Tissue: Current Status of Research Field", pp.66~68 (2018)
  9. Draeger A, "Primary, secondary and tertiary myotubes in developing skeletal muscle: A new approach to the analysis of human myogenesis", J Neuro Sci, 81(1), pp.19~43 (1987)
  10. Henry CA, "Zebrafish slow muscle cell migration induces a wave of fast muscle morphogenesis", Dev Cell, 7(6), pp.917~923 (2004)
  11. Cui Z, "Preliminary quantitative profile of differential protein expression between rat L6 myoblasts and myotubes by stable isotope labeling with amino acids in cell culture", Proteomics, 9(5), pp.1274~1292 (2009)
  12. Joe MK, "Myocilin Regulates Cell Proliferation and Survival", J Biol Chem, 289(14), pp.10155~10167 (2014)
  13. Zhang Y, "MYOC Promotes the Differentiation of C2C12 Cells by Regulation of the TGF-β Signaling Pathways via CAV1", Biology, 10(7), pp.686~ (2021)
  14. Milewska M, "Interleukin-8 enhances myocilin expression, Akt-FoxO3signaling and myogenic differentiation in rat skeletal muscle cells", J Cell Physiol, 234(11), pp.19675~19690 (2019)
  15. Rommel C, "Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K", Akt, Akt, pp.GSK3 pathways, Nat Cell Biol[DOI]
  16. Schabort EJ, "TGF-β’s delay skeletal muscle progenitor cell differentiation in an isoform-independent manner", Exp Cell Res, 315(3), pp.373~384 (2009)
  17. Riquelme-Guzmán C, "Expression of CTGF", CCN2 in response to LPA is stimulated by fibrotic extracellular matrix via the integrin, Am J Physiol Cell Physiol, pp.2018, 314(4)[DOI]
  18. Sehiaffino S, "Myosin isoforms in mammalian skeletal muscle", J Appl Physiol, 77(2), pp.493~501 (1994)
  19. Alberts, "Molecular Biology of The Cell", pp.915~925 (2014)
  20. Talbot J, "Skeletal muscle fiber type: using insights from muscle developmental biology to dissect targets for susceptibility and resistance to muscle disease", Wiley Interdiscip Rev Dev Biol, 5(4), pp.518~534 (2016)
  21. Ahmetov II, "Gene Polymorphisms and Fiber-Type Composition of Human Skeletal Muscle", Int J Sport Nutr Exerc Metab, 22(4), pp.292~303 (2012)
  22. Glass DJ, "Skeletal muscle hypertrophy and atrophy signaling pathways", Int J Biochem Cell Biol, 37(10), pp.1974~1984 (2005)
  23. Hornberger TA, "Mechanical Stimuli and Nutrients Regulate Rapamycin-Sensitive Signaling Through Distinct Mechanisms in Skeletal Muscle", J Cell Biochem, 97(6), pp.1207~1216 (2006)
  24. Jee HS, "High-Intensity Aerobic Exercise Suppresses Cancer Growth by Regulating Skeletal Muscle-Derived Oncogenes and Tumor Suppressors", Front Mol Biosci, 21(9), pp.818470~ (2022)
  25. Schiaffino S, "Fiber types in mammalian skeletal muscles", Physiol Rev, 91(4), pp.1447~1531 (2011)
  26. Saxton RA, "mTOR Signaling in Growth, Metabolism, and Disease", Cell, 168(6), pp.960~976 (2017)
  27. McCarthy JJ, "Anabolic and catabolic pathways regulating skeletal muscle mass", Curr Opin Clin Nutr Metab Care, 13(3), pp.230~235 (2010)
  28. Schreiber KH, "A novel rapamycin analog is highly selective for mTORC1 in vivo", Nat Commun, 10(1), pp.3194~3206 (2019)
  29. Kimball SR, "Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise", J Appl Physiol, 93(3), pp.1168~1180 (2002)
  30. Lee-Fruman KK, "Characterization of S6K2, a novel kinase homologous to S6K1", Oncogene, 18(36), pp.5108~5114 (1999)
  31. Sridharn S, "Distinct roles of mTOR Targets S6K1 and S6K2 in Breast Cancer", Int J Mol Sci, 21(4), pp.1199~1216 (2020)
  32. Koopman R, "Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers", Am J Physiol Endocrinol Metab, 290(6), pp.E1245~E1252 (2006)
  33. Chen X, "Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via Sirt1", AMPK pathway, 2018, pp.61, 155~162
  34. "KEGG Mapper"[URL]
  35. Kubota R, "A Novel Myosin-like Protein (Myocilin) Expressed in the Connecting Cilium of the Photoreceptor: Molecular Cloning, Tissue Expression, and Chromosomal Mapping", Genomics, 41(3), pp.360~369 (1997)
  36. Wentz–Hunter K, "Protein Interactions with Myocilin", Invest Ophthalmol Vis Sci, 43(1), pp.176~182 (2002)
  37. Milewska M, "Interleukin‐8 enhances myocilin expression, Akt‐FoxO3signaling and myogenic differentiation in rat skeletal muscle cells", J Cell Physiol, 234(11), pp.19675~19690 (2019)
  38. Joe MK, "Myocilin interacts with syntrophins and is member of dystrophin-associated protein complex", J Biol Chem, 287(16), pp.13216~13227 (2012)
  39. Lynch JM, "Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle", PLoS One, 13(11), pp.e0206801~ (2018)
  40. Martin MD, "Molecular architecture and modifications of full-length myocilin", Exp Eye Res, 211, pp.108729~ (2021)
  41. Judge SM, "MEF2c-dependent downregulation of Myocilin mediates cancer-induced muscle wasting and associates with cachexia in cancer patients", Cancer Res, 80(9), pp.1816~1874 (2020)
  42. Chen X, "Arginine promotes skeletal muscle fiber type transformation from fast-twitch to slow-twitch via Sirt1", AMPK pathway, 2018, pp.61, 155~162

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