Expression profiles of human endogenous retrovirus (HERV)-K and HERV-R Env proteins in various cancers
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The vertebrate genome contains an endogenous retrovirus that has been inherited from the past millions of years. Although approximately 8% of human chromosomal DNA consists of sequences derived from human endogenous retrovirus (HERV) fragments, most of the HERVs are currently inactive and noninfectious due to recombination, deletions, and mutations after insertion into the host genome. Several studies suggested that Human endogenous retroviruses (HERVs) factors are significantly related to certain cancers. However, only limited studies have been conducted to analyze the expression of HERV derived elements at protein levels in certain cancers. Herein, we analyzed the expression profiles of HERV-K envelope (Env) and HERV-R Env proteins in eleven different kinds of cancer tissues. Furthermore, the expression patterns of both protein and correlation with various clinical data in each tissue were analyzed. The expressions of both HERV-K Env and HERV-R Env protein were identified to be significantly high in most of the tumors compared with normal surrounding tissues. Correlations between HERV Env expressions and clinical investigations varied depending on the HERV types and cancers. Overall expression patterns of HERV-K Env and HERV-R Env proteins were different in every individual but a similar pattern of expressions was observed in the same individual. These results demonstrate the expression profiles of HERV-K and HERV-R Env proteins in various cancer tissues and provide a good reference for the association of endogenous retroviral Env proteins in the progression of various cancers. Furthermore, the results elucidate the relationship between HERV-Env expression and the clinical significance of certain cancers.
Abstract
The vertebrate genome contains an endogenous retrovirus that has been inherited from the past millions of years. Although approximately 8% of human chromosomal DNA consists of sequences derived from human endogenous retrovirus (HERV) fragments, most of the HERVs are currently inactive and noninfectious due to recombination, deletions, and mutations after insertion into the host genome. Several studies suggested that Human endogenous retroviruses (HERVs) factors are significantly related to certain cancers. However, only limited studies have been conducted to analyze the expression of HERV derived elements at protein levels in certain cancers. Herein, we analyzed the expression profiles of HERV-K envelope (Env) and HERV-R Env proteins in eleven different kinds of cancer tissues. Furthermore, the expression patterns of both protein and correlation with various clinical data in each tissue were analyzed. The expressions of both HERV-K Env and HERV-R Env protein were identified to be significantly high in most of the tumors compared with normal surrounding tissues. Correlations between HERV Env expressions and clinical investigations varied depending on the HERV types and cancers. Overall expression patterns of HERV-K Env and HERV-R Env proteins were different in every individual but a similar pattern of expressions was observed in the same individual. These results demonstrate the expression profiles of HERV-K and HERV-R Env proteins in various cancer tissues and provide a good reference for the association of endogenous retroviral Env proteins in the progression of various cancers. Furthermore, the results elucidate the relationship between HERV-Env expression and the clinical significance of certain cancers.
참고문헌 (32)
- Contreras-Galindo R, "Human endogenous retrovirus K(HML-2)elements in the plasma of people with lymphoma and breast cancer", J Virol, 82, pp.9329~9336 (2008)
- Conley AB, "Retroviral promoters in the human genome", Bioinformatics, 24, pp.1563~1567 (2008)
- Oja M, "Methods for estimating human endogenous retrovirus activities from EST databases", BMC Bioinformatics, 8(Suppl 2), pp.S11~ (2007)
- Perot P, "Microarraybased sketches of the HERV transcriptome landscape", PLoS One, 7, pp.e40194~ (2012)
- Ishida T, "Identification of the HERV-K gag antigen in prostate cancer by SEREX using autologous patient serum and its immunogenicity", Cancer Immun, 8, pp.15~ (2008)
- Hahn S, "Serological response to human endogenous retrovirus K in melanoma patients correlates with survival probability", AIDS Res Hum Retroviruses, 24, pp.717~723 (2008)
- Li M, "Downregulation of Human endogenous retrovirus type K(HERV-K)viral env RNA in pancreatic cancer cells decreases cell proliferation and tumor growth", Clin Cancer Res, 23, pp.5892~5911 (2017)
- Wang-Johanning F, "Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors", J Natl Cancer Inst, 104, pp.189~210 (2012)
- Kewitz S, "Expression and regulation of the endogenous retrovirus 3 in Hodgkin’s lymphoma cells", Front Oncol, 3, pp.179~ (2013)
- Lee SH, "Elevation of human ERV3-1 env protein expression in colorectal cancer", J Clin Pathol, 67, pp.840~844 (2014)
- Rhyu DW, "Expression of human endogenous retrovirus env genes in the blood of breast cancer patients", Int J Mol Sci, 15, pp.9173~9183 (2014)
- 김희수, "Expression profiles of HERV-K Env protein in normal and cancerous tissues", Genes & Genomics, 38(1), pp.91~107 (2016), 한국유전학회[DOI]
- 윤가영, "Long interspersed element-1 open reading frame 1 protein expression profiles in ovarian cancers", Genes & Genomics, 39(10), pp.1157~1162 (2017), 한국유전학회[DOI]
- Zhao J, "Expression of human endogenous retrovirus type K envelope protein is a novel candidate prognostic marker for human breast cancer", Genes Cancer, 2, pp.914~922 (2011)
- Krone B, "Melanoma, Darwinian medicine and the inner world", J Cancer Res Clin Oncol, 136, pp.1787~1794 (2010)
- Buscher K, "Expression of human endogenous retrovirus K in melanomas and melanoma cell lines", Cancer Res, 65, pp.4172~4180 (2005)
- Kang YJ, "Human ERV3-1 env protein expression in various human tissues and tumours", J Clin Pathol, 67, pp.86~90 (2014)
- Kurth R, "Beneficial and detrimental effects of human endogenous retroviruses", Int J Cancer, 126, pp.306~314 (2010)
- Bannert N, "Retroelements and the human genome : new perspectives on an old relation", Proc Natl Acad Sci U S A, 101(Suppl 2), pp.14572~14579 (2004)
- Romanish MT, "Potential mechanisms of endogenous retroviral-mediated genomic instability in human cancer", Semin Cancer Biol, 20, pp.246~253 (2010)
- Freimanis G, "A role for human endogenous retrovirus-K(HML-2)in rheumatoid arthritis : investigating mechanisms of pathogenesis", Clin Exp Immunol, 160, pp.340~347 (2010)
- Jeong BH, "The prevalence of human endogenous retroviruses in cerebrospinal fluids from patients with sporadic Creutzfeldt-Jakob disease", J Clin Virol, 47, pp.136~142 (2010)
- Blond JL, "An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor", J Virol, 74, pp.3321~3329 (2000)
- Mi S, "Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis", Nature, 403, pp.785~789 (2000)
- Tugnet N, "Human endogenous retroviruses(HERVs)and autoimmune rheumatic disease : is there a link?", Open Rheumatol J, 7, pp.13~21 (2013)
- Lindeskog M, "Spliced human endogenous retroviral HERV-H env transcripts in T-cell leukaemia cell lines and normal leukocytes : alternative splicing pattern of HERV-H transcripts", J Gen Virol, 78(Pt 10), pp.2575~2585 (1997)
- Wang-Johanning F, "Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma", Cancer, 98, pp.187~197 (2003)
- Kaufmann S, "Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor", J Gen Virol, 91, pp.1494~1502 (2010)
- Cegolon L, "Human endogenous retroviruses and cancer prevention : evidence and prospects", BMC Cancer, 13, pp.4~ (2013)
- Reiche J, "Differential expression of human endogenous retrovirus K transcripts in primary human melanocytes and melanoma cell lines after UV irradiation", Melanoma Res, 20, pp.435~440 (2010)
- Serafino A, "The activation of human endogenous retrovirus K(HERV-K)is implicated in melanoma cell malignant transformation", Exp Cell Res, 315, pp.849~862 (2009)
- Wang-Johanning F, "Quantitation of HERV-K env gene expression and splicing in human breast cancer", Oncogene, 22, pp.1528~1535 (2003)