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Human endogenous retroviruses and neurologic disorders

황문현|심영제
한국융합학회 (Korea Convergence Society)|2017.06|한국융합학회논문지 (Journal of the Korea Convergence Society)|제8권 제6호|pp. 275-281|DOI https://doi.org/10.15207/JKCS.2017.8.6.275

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참고문헌

키워드

schizophreniaamyotrophic lateral sclerosis정신 분열증Human endogenous retrovirusneurological diseasemultiple sclerosis인간 내인성 레트로 바이러스신경학적 질환다발성 경화증근 위축성 축삭경화증
주제분류학제간연구

초록

Human endogenous retroviruses (HERVs) are fossil viruses that began to be assimilated into the human genome some 30～40 million years ago, and now constitute nearly 8% of the human genome. These ancient retroviruses have since accumulated mutations that have rendered them defective; thus, they have been termed junk DNA. However, recent research indicates that not all HERVs remain silent passengers. Although they have not been shown to be causative of any human disease, endogenous retroviral sequences may become expressed under select pathological circumstances such as neurological disorders, including multiple sclerosis (MS), schizophrenia, and Amyotrophic Lateral Sclerosis (ALS); viral infections, including human immunodeficiency virus (HIV) and herpesvirus; and multiple types of cancers. This review focused on the possible interactions of HERVs and neurological diseases.

Abstract

Human endogenous retroviruses (HERVs) are fossil viruses that began to be assimilated into the human genome some 30～40 million years ago, and now constitute nearly 8% of the human genome. These ancient retroviruses have since accumulated mutations that have rendered them defective; thus, they have been termed junk DNA. However, recent research indicates that not all HERVs remain silent passengers. Although they have not been shown to be causative of any human disease, endogenous retroviral sequences may become expressed under select pathological circumstances such as neurological disorders, including multiple sclerosis (MS), schizophrenia, and Amyotrophic Lateral Sclerosis (ALS); viral infections, including human immunodeficiency virus (HIV) and herpesvirus; and multiple types of cancers. This review focused on the possible interactions of HERVs and neurological diseases.

참고문헌 (38)

  1. C. Patience, "Our retroviral heritage", Trends Genet, 12(3), pp.116~120 (1997)
  2. D. J. Griffiths, "Endogenous retroviruses in the human genome sequence", Genome Biology, 2(6) (2001)
  3. W. H. Li, "Evolutionary analyses of the human genome", Nature, 409(6822), pp.847~849 (2001)
  4. L. Cegolon, "Human endogenous retroviruses and cancer prevention: evidence and prospects", BMC Cancer, 13(4) (2013)
  5. N. Bannert, "Retroelements and the human genome: new perspectives on an old relation", Proceeding of the National Academy of Sciences of the USA, 101(Suppl. 2), pp.14572~14579 (2004)
  6. R. Löwer, "The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences", Proceeding of the National Academy of Sciences of the USA, 93(11), pp.5177~5184 (1996)
  7. G. R. Young, "Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis", Bioessays, 35(9), pp.794~803 (2013)
  8. M. Ono, "Molecular cloning and long terminal repeat sequences of human endogenous retrovirus genes related to types A and B retrovirus genes", Journal of Virology, 58(3), pp.937~944 (1986)
  9. R. Löwer, "Identification of human endogenous retroviruses with complex mRNA expression and particle formation", Proceeding of the National Academy of Sciences of the USA, 90(10), pp.4480~4484 (1993)
  10. T. Christensen, "Human endogenous retroviruses in neurologic disease", APMIS, 124(1-2), pp.116~126 (2016)
  11. M. Sospedra, "Immunology of multiple sclerosis", Annual Review of Immunology, 23, pp.683~747 (2005)
  12. S. V. Ramagopalan, "Multiple sclerosis: risk factors, prodromes, and potential causal pathways", The Lancet. Neurology, 9(7), pp.727~739 (2010)
  13. H. Tremlett, "New perspectives in the natural history of multiple sclerosis", Neurology, 74(24), pp.2004~2015 (2010)
  14. J. B. Johnston, "Monocyte activation and differentiation augment human endogenous retrovirus expression : implications for inflammatory brain diseases", Annals of Neurology, 50(4), pp.434~442 (2001)
  15. J. M. Antony, "The human endogenous retrovirus envelope glycoprotein, syncytin-1, regulates neuroinflammation and its receptor expression in multiple sclerosis: a role for endoplasmic reticulum chaperones in astrocytes", Journal of Immunology, 179(2), pp.1210~1224 (2007)
  16. H. Perron, "Human endogenous retrovirus (HERV)-W ENV and GAG proteins:physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesions", Journal of Neurovirology, 11(1), pp.23~33 (2005)
  17. J. M. Antony, "Human endogenous retroviruses and multiple sclerosis : innocent bystanders or disease determinants?", Biochimica et Biophysica Acta, 1812(2), pp.162~176 (2011)
  18. T. Christensen, "Antibodies against a human endogenous retrovirus and the preponderance of env splice variants in multiple sclerosis patients", Multiple Sclerosis, 9(1), pp.6~15 (2003)
  19. T. Brudek, "B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity", Retrovirology, 6 (2009)
  20. A. K. Tai, "Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis", Multiple Sclerosis, 14(9), pp.1175~1180 (2008)
  21. R. Tandon, "Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology", Schizophrenia Research, 102(1-3), pp.1~18 (2008)
  22. H. Hegyi, "GABBR1 has a HERV-W LTR in its regulatory region--a possible implication for schizophrenia", Biology Direct, 8 (2013)
  23. A. E. Pulver, "Search for schizophrenia susceptibility genes", Biological Psychiatry, 47(3), pp.221~230 (2000)
  24. M. Tsuang, "Schizophrenia : genes and environment", Biological Psychiatry, 47(3), pp.210~220 (2000)
  25. R. H. Yolken, "Endogenous retroviruses and schizophrenia", Brain Research. Brain Research Review, 31(2-3), pp.193~199 (2000)
  26. H. Karlsson, "Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia", Proceeding of the National Academy of Sciences of the USA, 98(8), pp.4634~4639 (2001)
  27. H. Karlsson, "HERV-W-related RNA detected in plasma from individuals with recent-onset schizophrenia or schizoaffective disorder", Molecular Psychiatry, 9(1), pp.12~13 (2004)
  28. W. Huang, "Implication of the env gene of the HERV-W family in the expression of BDNF and DRD3 and development of recent-onset schizophrenia", Schizophrenia Bulletin, 37(5), pp.988~1000 (2010)
  29. O. Frank, "Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorders", Journal of Virology, 79(17), pp.10890~10901 (2005)
  30. S. Ajroud-Driss, "Sporadic and hereditary amyotrophic lateral sclerosis(ALS)", Biochimica et Biophysica Acta, 1852(4), pp.679~684 (2015)
  31. T. Alfahad, "Retroviruses and amyotrophic lateral sclerosis", Antiviral Research, 99(2), pp.180~187 (2016)
  32. F. Navone, "Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALSS", Cells, 4(3), pp.354~486 (2015)
  33. S. Vucic, "Pathophysiology of neurodegeneration in familial amyotrophic lateral sclerosis", Current Molecular Medicine, 9(3), pp.255~272 (2009)
  34. A. Verma, "ALS syndrome in patients with HIV-1 infection", Journal of the Neurological Sciences, 240(1-2), pp.59~64 (2006)
  35. A. Moulignier, "Reversible ALS-like disorder in HIV infection", Neurology, 57(6), pp.995~1001 (2001)
  36. P. Jolicoeur, "Neuronal loss in a lower motor neuron disease induced by a murine retrovirus", The Canadian Journal of Neurological Sciences, 18(3 Suppl), pp.411~413 (1991)
  37. A. L. McCormick, "Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate", Neurology, 70(4), pp.278~283 (2008)
  38. R. Douville, "Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis", Annals Neurology, 69(1), pp.141~151 (2011)

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