Immunomodulatory Effects of Hypocrellin A on MHC-restricted Antigen Processing
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2Kb-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
Abstract
Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the H-2Kb-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.
참고문헌 (22)
- He YY, "Synthesis and EPR investigations of new aminated hypocrellin derivatives", Free Radic Biol Med, 28, pp.1642~1651 (2000)
- Wan XY, "Hypocrellin A, a new drug for photochemotherapy", Chinese Sci Bull, 26, pp.1040~1041 (1981)
- Ma JS, "Hypocrellin-A sensitized photooxidation of bilirubin", Photochem Photobiol, 50, pp.827~830 (1989)
- Schinazi RF, "Anthraquinones as a new class of antiviral agents against human immunodeficiency virus", Antiviral Res, 13, pp.265~272 (1990)
- Daub ME, "The photoactivated cercospora toxin cercosporin: Contributions to Plant Disease and Fundamental Biology", Annu Rev Phytopathol, 38, pp.461~490 (2000)
- Ma L, "Photodynamic inhibitory effects of three perylenequinones on human colorectal carcinoma cell line and primate embryonic stem cell line", World J Gastroenterol, 9, pp.485~490 (2003)
- Liang XH, "Isolation and identification of a new hypocrellin A-producing strain Shiraia sp. SUPER-H168", Microbiol Res, 164, pp.9~17 (2009)
- Ali SM,Chee SK, "Hypocrellins and hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide", Int J Mol Med, 9, pp.461~472 (2002)
- Diwu Z, "Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: perylenequinonoid pigments", Biochem Pharmacol, 47, pp.373~385 (1994)
- Park J, "The role of oxygen in the antiviral activity of hypericin and hypocrellin", Photochem Photobiol, 68, pp.593~597 (1998)
- Ma G, "Antimicrobial and antileishmanial activities of hypocrellins A and B", Antimicrob Agents Chemother, 48, pp.4450~4452 (2004)
- Turmunkh Gerelchuluun, "Dendritic Cells Process Antigens Encapsulated in a Biodegradable Polymer, Poly(D,L-lactide-co-glycolide), via an Alternate Class I MHC Processing Pathway", Archives of Pharmacal Research, 30(11), pp.1440~1446 (2007), 대한약학회
- Lee YR, "Cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells", BLOOD, 105, pp.3951~3955, AMER SOC HEMATOLOGY
- Lee YH, "Baccatin III, a synthetic precursor of taxol, enhances MHC-restricted antigen presentation in dendritic cells", Int Immunopharmacol, 11, pp.985~991 (2011)
- Harding CV, "Phagocytic processing of antigens for presentation by MHC molecules", Trends Cell Biol, 5, pp.105~109 (1995)
- Heath WR, "Cross-presentation, dendritic cells, tolerance and immunity", Annu Rev Immunol, 19, pp.47~64 (2001)
- Carbone FR, "Cross-presentation: a general mechanism for CTL immunity and tolerance", Immunol Today, 19, pp.368~373 (1998)
- Ackerman AL, "Cellular mechanisms governing cross-presentation of exogenous antigens", Nat Immunol, 5, pp.678~684 (2004)
- Groothuis TA, "The many roads to crosspresentation", J Exp Med, 202, pp.1313~1318 (2005)
- Kovacsovics-Bankowski M, "A phagosome-to- cytosol pathway for exogenous antigens presented on MHC class I molecules", Science, 267, pp.243~246 (1995)
- Ojcius DM, "Dissociation of the peptide", MHC class I complex: pH dependence and effect of endogenous peptides on the activation energy, 1993, pp.197, 1216~1222
- Diwu Z, "Novel therapeutic and diagnostic applications of hypocrellins and hypericins", Photochem Photobiol, 61, pp.529~539 (1995)