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Inhibition of Major Histocompatibility Complex (MHC)- Restricted Presentation of Exogenous Antigen in Dendritic Cells by Korean Propolis Components

이종길|김경제|이승정|송영천|하남주|한신하|조경해
대한면역학회 (The Korean Association of Immunologists)|2005.09|Immune Network|제5권 제3호|pp. 150-156

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Abstract

Background: Dendritic cells (DCs) play a critical role not only in the initiation of immune responses, but also in the induction of immune tolerance. In an effort to regulate immune responses through the modulation of antigen presenting cell (APC) function of DCs, we searched for and characterized APC function modulators from natural products. Methods: DCs were cultured in the presence of propolis components, WP and CP, and then examined for their ability to present exogenous antigen in association with major histocompatibility complexes (MHC). Results: WP and CP inhibited class I MHC-restricted presentation of exogenous antigen (cross-presentation) in a DC cell line, DC2.4 cells, and DCs generated from bone marrow cells with GM-CSF and IL-4. The inhibitory activity of WP and CP appeared to be due not only to inhibition of phagocytic activity of DCs, but also to suppression of expression of MHC molecules on DCs. We also examined the effects of WP and CP on T cells. Interestingly, WP and CP increased IL-2 production from T cells. Conclusion: These results demonstrate that WP and CP inhibit MHC-restricted presentation of exogenous antigen through down-regulation of phagocytic activity and suppression of expression of MHC molecules on DCs.

참고문헌 (33)

  1. "MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells", 89, pp.125~131 (2003)
  2. "Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte", macrophage colony-stimulating factor, 1992, pp.176, 1693~1702
  3. "Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules", 15, pp.2723~2730 (1997)
  4. "Eradication of established murine tumors using a novel cell-free vaccine", 4, pp.594~600 (1998)
  5. "function and potential use for cancer immunotherapy", pp.51~64 (1999)
  6. "Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity", 183, pp.283~287 (1996)
  7. "Dendritic cells presenting tumor antigen", 43, pp.158~164 (1996)
  8. "New tools for antigen delivery to the MHC class I pathway", 25, pp.92~97 (2004)
  9. "Cross-talk relevant in innate anti-tumor immune responses in vivo", 5, pp.405~411 (1999)
  10. "Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo", 95, pp.9482~9487 (1998)
  11. "Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells", 166, pp.182~194 (1987)
  12. "Recognition of chronic myelogenous leukemia cells by autologous T lymphocytes primed in vitro against the patient's dendritic cells", 112, pp.740~748 (2001)
  13. "Characterization of the MHC class I cross- presentation pathway for cell-associated antigens by human dendritic cells", 102, pp.4448~4455 (2003)
  14. "Dendritic cells:a link between innate and adaptive immunity", 19, pp.12~25 (1999)
  15. "Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo", 24, pp.605~610 (1994)
  16. "Dendritic cells in cancer immunotherapy", 18, pp.245~273 (2000)
  17. "Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells", 3, pp.558~561 (1997)
  18. "Activation of antitumor cytotoxic T lymphocytes by fusions of human dendritic cells and breast carcinoma cells", 97, pp.2715~2718 (2000)
  19. "Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific MHC-restricted T cells in situ", 172, pp.631~640 (1990)
  20. "Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity", 1, pp.1297~1302 (1995)
  21. "Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells", 1, pp.1275~1284 (2001)
  22. "inhibit MHC-restricted antigen presentation pathways in dendritic cells", 105, pp.3951~3955 (2005)
  23. "Activation of murine macrophage cell line RAW 264 7 by Korean Propolis", 25, pp.895~902 (2002)
  24. "Immunomodulatory action of propolis Anticomplementary activity of a water-soluble derivative", i47, pp.135~143 (1995)
  25. "Advances in flavonoid research since 1992", 55, pp.481~504 (2000)
  26. "Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules", 158, pp.2723~2730 (1977)
  27. "Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens", 89, pp.6020~6024 (1992)
  28. "Liposome-encapsulated antigens engender lysosomal processing for class II MHC presentation and cytosolic processing for class I presentation", 147, pp.2860~2863 (1991)
  29. "and in situ detection of specific peptide-MHC class I complexes using monoclonal antibody", 6, pp.715~726 (1997)
  30. "IL-3 enhances both presentation of exogenous particulate antigen in association with class I major histocompatibility antigen and generation of primary tumor-specific cytolytic T lymphocytes", 160, pp.5773~5780 (1998)
  31. "Dendritic cells resurrect antigens from dead cells", 22, pp.141~148 (2001)
  32. "Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo implications for generating CD8+ T cell responses to infectious agents", 73, pp.1~77 (1999)
  33. "Antigen capture, processing, and presentation by dendritic cells", 60, pp.562~567 (1999)

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