Homocysteine levels are associated with diabetes mellitus in Chinese with H-type hypertension
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
BACKGROUND/OBJECTIVESThe study examined the association between homocysteine and diabetes mellitus in patients with H-type hypertension and assessed the possible effect modifiers. SUBJECTS/METHODSThis cross-sectional study included 1,255 eligible participants in the ‘H-type Hypertension Management and Stroke Prevention Strategic International Science and Technology Innovation Cooperation Project’ among rural Chinese people with H-type hypertension. A multivariate logistic regression model was used to evaluate the relationship between homocysteine and diabetes mellitus. RESULTSThe mean level of total homocysteine (tHcy) in the diabetes mellitus population was 19.37 μmol/L, which was significantly higher than the non-diabetic patients (18.18 μmol/L). When tHcy was analyzed as a continuous variable, the odds ratio (OR) of diabetes was 1.17 (95% confidence interval [CI], 1.01–1.35; per interquartile range). When tHcy was stratified according to the quintile, the ORs for diabetes were 2.86 (95% CI, 1.22–6.69) in the highest quintile (tHcy ≥ 20.60 μmol/L) compared to the reference group (tHcy < 12.04 μmol/L). When tHcy was grouped by 15 μmol/L and 20 μmol/L, patients with tHcy ≥ 20 μmol/L had a significantly (P = 0.037) higher risk of diabetes (OR, 2.03; 95% CI, 1.04–3.96) than in those with tHcy < 15 μmol/L. Subgroup analysis showed that the tHcy-diabetes association was unaffected by other variables. CONCLUSIONIn this study of rural Chinese people with H-type hypertension, the tHcy levels showed a positive association with diabetes mellitus. This independent association is unaffected by other potential risk factors.
Abstract
BACKGROUND/OBJECTIVESThe study examined the association between homocysteine and diabetes mellitus in patients with H-type hypertension and assessed the possible effect modifiers. SUBJECTS/METHODSThis cross-sectional study included 1,255 eligible participants in the ‘H-type Hypertension Management and Stroke Prevention Strategic International Science and Technology Innovation Cooperation Project’ among rural Chinese people with H-type hypertension. A multivariate logistic regression model was used to evaluate the relationship between homocysteine and diabetes mellitus. RESULTSThe mean level of total homocysteine (tHcy) in the diabetes mellitus population was 19.37 μmol/L, which was significantly higher than the non-diabetic patients (18.18 μmol/L). When tHcy was analyzed as a continuous variable, the odds ratio (OR) of diabetes was 1.17 (95% confidence interval [CI], 1.01–1.35; per interquartile range). When tHcy was stratified according to the quintile, the ORs for diabetes were 2.86 (95% CI, 1.22–6.69) in the highest quintile (tHcy ≥ 20.60 μmol/L) compared to the reference group (tHcy < 12.04 μmol/L). When tHcy was grouped by 15 μmol/L and 20 μmol/L, patients with tHcy ≥ 20 μmol/L had a significantly (P = 0.037) higher risk of diabetes (OR, 2.03; 95% CI, 1.04–3.96) than in those with tHcy < 15 μmol/L. Subgroup analysis showed that the tHcy-diabetes association was unaffected by other variables. CONCLUSIONIn this study of rural Chinese people with H-type hypertension, the tHcy levels showed a positive association with diabetes mellitus. This independent association is unaffected by other potential risk factors.
참고문헌 (48)
- Chatterjee S, "Type 2 diabetes", Lancet, 389, pp.2239~2251 (2017)
- Boushey CJ, "A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes", JAMA, 274, pp.1049~1057 (1995)
- Verhoef P, "Homocysteine metabolism and risk of myocardial infarction : relation with vitamins B6, B12, and folate", Am J Epidemiol, 143, pp.845~859 (1996)
- Emoto M, "Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes", Diabetes Care, 24, pp.533~538 (2001)
- Hoogeveen EK, "Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus : a population-based study", Arterioscler Thromb Vasc Biol, 18, pp.133~138 (1998)
- Ala OA, "Association between insulin resistance and total plasma homocysteine levels in type 2 diabetes mellitus patients in south west Nigeria", Diabetes Metab Syndr (2017)
- Ndrepepa G, "Circulating homocysteine levels in patients with type 2 diabetes mellitus", Nutr Metab Cardiovasc Dis, 18, pp.66~73 (2008)
- Passaro A, "Factors influencing plasma homocysteine levels in type 2 diabetes", Diabetes Care, 23, pp.420~421 (2000)
- Yu C, "Inverse association between plasma homocysteine concentrations and type 2 diabetes mellitus among a middle-aged and elderly Chinese population", Nutr Metab Cardiovasc Dis, 28, pp.278~284 (2018)
- "Executive summary: standards of medical care in diabetes--2010", Diabetes Care, 33, pp.4~10 (2010)
- Ebesunun MO, "Elevated plasma homocysteine in type 2 diabetes mellitus : a risk factor for cardiovascular diseases", Pan Afr Med J, 12, pp.48~ (2012)
- Yuan X, "Association between plasma homocysteine levels and pancreatic islet beta-cell function in the patients with type 2 diabetes mellitus : a cross-sectional study from China", Ann Palliat Med, 10, pp.8169~8179 (2021)
- Schaffer A, "Impact of diabetes on homocysteine levels and its relationship with coronary artery disease : a single-centre cohort study", Ann Nutr Metab, 68, pp.180~188 (2016)
- Platt DE, "Type II diabetes mellitus and hyperhomocysteinemia : a complex interaction", Diabetol Metab Syndr, 9, pp.19~ (2017)
- Wang YS, "Association of retinol binding protein-4, cystatin C, homocysteine and high-sensitivity C-reactive protein levels in patients with newly diagnosed type 2 diabetes mellitus", Arch Med Sci, 15, pp.1203~1216 (2019)
- Qin X, "Relationship of MTHFR gene 677C → T polymorphism, homocysteine, and estimated glomerular filtration rate levels with the risk of new-onset diabetes", Medicine(Baltimore), 94, pp.e563~ (2015)
- Smulders YM, "Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and cardiovascular disease", Diabetes Care, 22, pp.125~132 (1999)
- Buysschaert M, "Hyperhomocysteinemia in type 2 diabetes : relationship to macroangiopathy, nephropathy, and insulin resistance", Diabetes Care, 23, pp.1816~1822 (2000)
- Koehler KM, "Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use", Am J Clin Nutr, 73, pp.628~637 (2001)
- Stickel F, "Effect of chronic alcohol consumption on total plasma homocysteine level in rats", Alcohol Clin Exp Res, 24, pp.259~264 (2000)
- Russo GT, "Correlates of total homocysteine plasma concentration in type 2 diabetes", Eur J Clin Invest, 34, pp.197~204 (2004)
- Wang B, "Effect of long-term low-dose folic acid supplementation on degree of total homocysteine-lowering : major effect modifiers", Br J Nutr, 120, pp.1122~1130 (2018)
- Refsum H, "Facts and recommendations about total homocysteine determinations : an expert opinion", Clin Chem, 50, pp.3~32 (2004)
- Thögersen AM, "Homozygosity for the C677-->T mutation of 5, 10-methylenetetrahydrofolate reductase and total plasma homocyst(e)ine are not associated with greater than normal risk of a first myocardial infarction in northern Sweden", Coron Artery Dis, 12, pp.85~90 (2001)
- Friedman G, "A common mutation A1298C in human methylenetetrahydrofolate reductase gene : association with plasma total homocysteine and folate concentrations", J Nutr, 129, pp.1656~1661 (1999)
- Stampfer MJ, "Can homocysteine be related to physical functioning", Am J Med, 113, pp.610~611 (2002)
- Han L, "Determinants of hyperhomocysteinemia in healthy and hypertensive subjects : a population-based study and systematic review", Clin Nutr, 36, pp.1215~1230 (2017)
- Challa F, "Prevalence of hyperhomocysteinaemia and associated factors among Ethiopian adult population in a 2015 national survey", BioMed Res Int, 2020, pp.9210261~ (2020)
- Zeng Q, "Influence of food groups on plasma total homocysteine for specific MTHFR C677T genotypes in Chinese population", Mol Nutr Food Res, 61, pp.1600351~ (2017)
- Shi C, "Nutritional and medical food therapies for diabetic retinopathy", Eye Vis(Lond), 7, pp.33~ (2020)
- Selhub J, "Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey(1991-1994) : population reference ranges and contribution of vitamin status to high serum concentrations", Ann Intern Med, 131, pp.331~339 (1999)
- Brattström L, "Vitamins as homocysteine-lowering agents", J Nutr, 126, pp.1276~ (1996)
- Jacob RA, "Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction", J Nutr, 124, pp.1072~1080 (1994)
- Selhub J, "Vitamin status and intake as primary determinants of homocysteinemia in an elderly population", JAMA, 270, pp.2693~2698 (1993)
- Aydemir O, "Plasma and vitreous homocysteine concentrations in patients with proliferative diabetic retinopathy", Retina, 28, pp.741~743 (2008)
- Wang T, "Diagnostic value of the combined measurement of serum Hcy, serum Cys C, and urinary microalbumin in type 2 diabetes mellitus with early complicating diabetic nephropathy", ISRN Endocrinol, 2013, pp.407452~ (2013)
- Zheng LQ, "Elevated serum homocysteine level in the development of diabetic peripheral neuropathy", Genet Mol Res, 14, pp.15365~15375 (2015)
- Hermans MP, "The MTHFR CT polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with type 2 diabetes", Diabet Med, 23, pp.529~536 (2006)
- Ostrakhovitch EA, "Homocysteine and age-associated disorders", Ageing Res Rev, 49, pp.144~164 (2019)
- Shin JY, "Trends in the prevalence and management of diabetes in Korea : 2007-2017", Epidemiol Health, 41, pp.e2019029~ (2019)
- Xu R, "Gender-and age-related differences in homocysteine concentration : a cross-sectional study of the general population of China", Sci Rep, 10, pp.17401~ (2020)
- Blom HJ, "Determinants of plasma homocysteine", Am J Clin Nutr, 67, pp.188~189 (1998)
- Choi SH, "Poor nutrition and alcohol consumption are related to high serum homocysteine level at post-stroke", Nutr Res Pract, 9, pp.503~510 (2015)
- Hornemann T, "Serine deficiency causes complications in diabetes", Nature, 614, pp.42~43 (2023)
- Yang M, "Serine and one-carbon metabolism in cancer", Nat Rev Cancer, 16, pp.650~662 (2016)
- Davis SR, "Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor", Am J Physiol Endocrinol Metab, 286, pp.E272~9 (2004)
- Cole JB, "Genetics of diabetes mellitus and diabetes complications", Nat Rev Nephrol, 16, pp.377~390 (2020)
- Morrish NJ, "Mortality and causes of death in the WHO multinational study of vascular disease in diabetes", Diabetologia, 44, pp.14~21 (2001)