Effects of folic acid supplementation on serum homocysteine levels, lipid profiles, and vascular parameters in post-menopausal Korean women with type 2 diabetes mellitus
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BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 μg of folic acid (400 μg twice a day) daily. Subjects’ serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.
Abstract
BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 μg of folic acid (400 μg twice a day) daily. Subjects’ serum levels of folate, homocysteine, and vitamin B12 were measured, along with vascular function and brachial-ankle pulse wave velocity. RESULTS: Folic acid supplementation significantly increased serum folate levels (P < 0.0001), reduced homocysteine levels (P < 0.0001), and increased vitamin B12 levels (P = 0.0063). There were significant decreases in low-density lipoprotein cholesterol levels as well as the ratios of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol and total cholesterol to high-density lipoprotein cholesterol. Brachial-ankle pulse wave velocities were not altered by supplementation. Changes in serum vitamin B12 after folic acid supplementation were negatively correlated with changes in brachial-ankle pulse wave velocity. CONCLUSIONS: In this study on postmenopausal Korean women with type 2 diabetes mellitus, folic acid supplementation reduced serum homocysteine levels, increased serum folate and vitamin B12 levels, and lowered lipid parameters.
참고문헌 (48)
- Wei M, "Effects of diabetes and level of glycemia on all-cause and cardiovascular mortality. The San Antonio Heart Study", Diabetes Care, 21, pp.1167~1172 (1998)
- de Oliveira Alvim R, "Impact of diabetes mellitus on arterial stiffness in a representative sample of an urban Brazilian population", Diabetol Metab Syndr, 5, pp.45~ (2013)
- van de Ree MA, "Impaired endothelium-dependent vasodilation in type 2 diabetes mellitus and the lack of effect of simvastatin", Cardiovasc Res, 52, pp.299~305 (2001)
- Levitzky YS, "Impact of impaired fasting glucose on cardiovascular disease: the Framingham Heart Study", J Am Coll Cardiol, 51, pp.264~270 (2008)
- Elley CR, "Glycated haemoglobin and cardiovascular outcomes in people with Type 2 diabetes: a large prospective cohort study", Diabet Med, 25, pp.1295~1301 (2008)
- Turner RC, "Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23)", BMJ, 316, pp.823~828 (1998)
- Audelin MC, "Homocysteine and cardiovascular disease in diabetes mellitus", Atherosclerosis, 159, pp.497~511 (2001)
- Pfanzagl B, "Homocysteine strongly enhances metal-catalyzed LDL oxidation in the presence of cystine and cysteine", Atherosclerosis, 168, pp.39~48 (2003)
- Jin L, "Homocysteine induces endothelial dysfunction via inhibition of arginine transport", J Physiol Pharmacol, 58, pp.191~206 (2007)
- Patterson S, "Prolonged exposure to homocysteine results in diminished but reversible pancreatic β-cell responsiveness to insulinotropic agents", Diabetes Metab Res Rev, 23, pp.324~334 (2007)
- Patterson S, "Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity", Arch Biochem Biophys, 461, pp.287~293 (2007)
- Wouters MG, "Plasma homocysteine and menopausal status", Eur J Clin Invest, 25, pp.801~805 (1995)
- El-Kadi MA, "The effect of folic acid supplementation on serum homocysteine of egyptian post menopausal women: a randomized controlled trial", Middle East Fertil Soc J, 19, pp.192~196 (2014)
- Qin X, "Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials", Atherosclerosis, 222, pp.307~313 (2012)
- Chambers JC, "Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine", Circulation, 102, pp.2479~2483 (2000)
- Paradisi G, "Endothelial function in post-menopausal women: effect of folic acid supplementation", Hum Reprod, 19, pp.1031~1035 (2004)
- Villa P, "L-folic acid supplementation in healthy postmenopausal women: effect on homocysteine and glycolipid metabolism", J Clin Endocrinol Metab, 90, pp.4622~4629 (2005)
- Sultan N, "Effect of folic acid supplementation on homocysteine level in postmenopausal women", J Ayub Med Coll Abbottabad, 19, pp.78~81 (2007)
- Mangoni AA, "Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes", Am J Hypertens, 18, pp.220~226 (2005)
- Albert CM, "Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial", JAMA, 299, pp.2027~2036 (2008)
- 김혜숙, "Association between fish and shellfish, and omega-3 PUFAs intake and CVD risk factors in middle-aged female patients with type 2 diabetes", Nutrition Research and Practice, 9(5), pp.496~502 (2015), 한국영양학회[DOI]
- Cardiovascular Disease and Diabetes: Policies for Better Health and Quality of Care, "Organisation for Economic Co-operation and Development", Organisation for Economic Co-operation and Development, 111~131 (2015)
- Durga J, "Effect of 3 y of folic acid supplementation on the progression of carotid intima-media thickness and carotid arterial stiffness in older adults", Am J Clin Nutr, 93, pp.941~949 (2011)
- Friedewald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge", Clin Chem, 18, pp.499~502 (1972)
- Lauer M, "Factors affecting the relationship between childhood and adult cholesterol levels: the Muscatine Study", Pediatrics, 82, pp.309~318 (1988)
- Yamashina A, "Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement", Hypertens Res, 25, pp.359~364 (2002)
- Kweon Sun Seog, "Distribution of the Ankle-Brachial Index and Associated Cardiovascular Risk Factors in a Population of Middle-Aged and Elderly Koreans", Journal of Korean Medical Science, 20(3), pp.373~378 (2005), 대한의학회
- Millán J, "Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention", Vasc Health Risk Manag, 5, pp.757~765 (2009)
- da Luz PL, "High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease", Clinics (Sao Paulo), 63, pp.427~432 (2008)
- Keser I, "Folic acid and vitamin B(12) supplementation lowers plasma homocysteine but has no effect on serum bone turnover markers in elderly women: a randomized, double-blind, placebo-controlled trial", Nutr Res, 33, pp.211~219 (2013)
- Aboyans V, "Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association", Circulation, 126, pp.2890~2909 (2012)
- Wu L, "Distribution of brachial-ankle pulse wave velocity values and optimal cut-off in distinguishing subjects with clinical condition in Chinese population", Int Angiol, 31, pp.252~259 (2012)
- Tehlivets O., "Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism?", J Lipids, 2011, pp.702853~ (2011)
- Young IS, "Folate and homocysteine", Curr Opin Clin Nutr Metab Care, 3, pp.427~432 (2000)
- Banerjee RV, "Cobalamin-dependent methionine synthase", FASEB J, 4, pp.1450~1459 (1990)
- Bostom AG, "Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients", Atherosclerosis, 123, pp.193~202 (1996)
- Title LM, "Folic acid improves endothelial dysfunction in type 2 diabetes--an effect independent of homocysteine-lowering", Vasc Med, 11, pp.101~109 (2006)
- Liao D, "Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance", Circ Res, 99, pp.598~606 (2006)
- Namekata K, "Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia", J Biol Chem, 279, pp.52961~52969 (2004)
- Werstuck GH, "Homocysteineinduced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways", J Clin Invest, 107, pp.1263~1273 (2001)
- Adaikalakoteswari A, "Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes", Cardiovasc Diabetol, 13, pp.129~ (2014)
- Shargorodsky M, "Serum homocysteine, folate, vitamin B12 levels and arterial stiffness in diabetic patients: which of them is really important in atherogenesis?", Diabetes Metab Res Rev, 25, pp.70~75 (2009)
- Nappo F, "Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins", JAMA, 281, pp.2113~2118 (1999)
- el-Swefy SE, "Hyperhomocysteinaemia and cardiovascular risk in female ovariectomized rats: role of folic acid and hormone replacement therapy", J Pharm Pharmacol, 54, pp.391~397 (2002)
- Xia XS, "Supplementation of folic acid and vitamin B12 reduces plasma levels of asymmetric dimethylarginine in patients with acute ischemic stroke", J Clin Neurosci, 21, pp.1586~1590 (2014)
- Sibal L, "The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease", Curr Cardiol Rev, 6, pp.82~90 (2010)
- Protopsaltis I, "Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals", Cardiovasc Diabetol, 11, pp.141~ (2012)
- Koyama K, "Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis", Am J Kidney Dis, 55, pp.1069~1078 (2010)
